Results 1 to 10 of about 80 (66)
ANT2-defective fibroblasts exhibit normal mitochondrial bioenergetics
Molecular Genetics and Metabolism Reports, 2015 Adenine nucleotide translocase 2 (ANT2) transports glycolytic ATP across the inner mitochondrial membrane. Patients with ANT2 deletion were recently reported. We aimed at characterizing mitochondrial functions in ANT2-defective fibroblasts.
Manuel Schiff +2 more
exaly +3 more sources
ANT2 drives proinflammatory macrophage activation in obesity
JCI Insight, 2021 Macrophage proinflammatory activation is an important etiologic component of the development of insulin resistance and metabolic dysfunction in obesity. However, the underlying mechanisms are not clearly understood.
Yun Sok Lee, Jin Young Huh, Jae-Su Moon
exaly +2 more sources
Degradation of HER2/neu by ANT2 shRNA suppresses migration and invasiveness of breast cancer cells
BMC Cancer, 2010 Background In breast cancer, the HER2/neu oncoprotein, which belongs to the epidermal growth factor receptor family, may trigger activation of the phosphoinositide-3 kinase (PI3K)/Akt pathway, which controls cell proliferation, survival, migration, and ...
Yoon-Kyung Jeon, Ji-Young Jang
exaly +3 more sources
Nature CommunicationsT cell activation requires a substantial increase in NAD+ production, often exceeding the capacity of oxidative phosphorylation (OXPHOS). To investigate how T cells adapt to this metabolic challenge, we generate T cell-specific ADP/ATP translocase-2 ...
Joseph Tam +2 more
exaly +2 more sources
Current Issues in Molecular Biology, 2023 Mitochondrial dysfunction is known to play a critical role in the development of cardiomyocyte death during acute myocardial infarction (AMI). However, the exact mechanisms underlying this dysfunction are still under investigation.
Meng Zhang +4 more
doaj +1 more source
Suppression of ANT2 by miR-137 Inhibits Prostate Tumorigenesis
Frontiers in Genetics, 2021 Prostate cancer (PCa) is a serious disease that affects men’s health. To date, no effective and long-lasting treatment option for this condition is available in clinical practice.
Heyuan Zhang +11 more
doaj +1 more source
Regulation of the Flavonoid Biosynthesis Pathway Genes in Purple and Black Grains of Hordeum vulgare. [PDF]
PLoS ONE, 2016 Barley grain at maturity can have yellow, purple, blue, and black pigmentations which are suggested to play a protective role under stress conditions. The first three types of the colors are caused by phenolic compounds flavonoids; the last one is caused
Olesya Yu Shoeva +4 more
doaj +1 more source
Mitochondrial Respiration-Dependent ANT2-UCP2 Interaction
Frontiers in Physiology, 2022 Adenine nucleotide translocases (ANTs) and uncoupling proteins (UCPs) are known to facilitate proton leak across the inner mitochondrial membrane. However, it remains to be unravelled whether UCP2/3 contribute to significant amount of proton leak in vivo.
Tomas A. Schiffer +5 more
doaj +1 more source
Evolutionary genomics implies a specific function of Ant4 in mammalian and anole lizard male germ cells. [PDF]
PLoS ONE, 2011 Most vertebrates have three paralogous genes with identical intron-exon structures and a high degree of sequence identity that encode mitochondrial adenine nucleotide translocase (Ant) proteins, Ant1 (Slc25a4), Ant2 (Slc25a5) and Ant3 (Slc25a6). Recently,
Chae Ho Lim +4 more
doaj +1 more source
Acta Pharmaceutica Sinica B, 2021 IF1 (ATPIF1) is a nuclear DNA-encoded mitochondrial protein whose activity is inhibition of the F1Fo-ATP synthase to control ATP production. IF1 activity remains unknown in the regulation of GLP-1 activity.
Ying Wang +10 more
doaj +1 more source