Results 21 to 30 of about 431 (145)

The product of the Herpes simplex virus 1 UL7 gene interacts with a mitochondrial protein, adenine nucleotide translocator 2 [PDF]

Virology Journal, 2008
The herpes simplex virus 1 (HSV-1) UL7 gene is highly conserved among herpesviridae. Since the construction of recombinant HSV-1 with a mutation in the UL7 gene has not been reported, the involvement of HSV-1 UL7 in viral replication has been unclear. In
Kawaguchi Yasushi, Sata Tetsutaro, Tanaka Michiko   +2 more
doaj   +2 more sources

The UL16 protein of HSV-1 promotes the metabolism of cell mitochondria by binding to ANT2 protein [PDF]

Scientific Reports, 2021
Long-term studies have shown that virus infection affects the energy metabolism of host cells, which mainly affects the function of mitochondria and leads to the hydrolysis of ATP in host cells, but it is not clear how virus infection participates in ...
Shiyu Li, Shuting Liu, Zhenning Dai, Qian Zhang, Yichao Xu, Youyu Chen, Zhenyou Jiang, Wenhua Huang, Hanxiao Sun   +8 more
doaj   +3 more sources

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology
Cellular senescence has recently been recognized as a significant contributor to the poor prognosis of glioblastoma, one of the most aggressive brain tumors. Consequently, effectively eliminating senescent glioblastoma cells could benefit patients. Human
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
doaj   +2 more sources

The Mammalian Proteins MMS19, MIP18, and ANT2 Are Involved in Cytoplasmic Iron-Sulfur Cluster Protein Assembly [PDF]

Journal of Biological Chemistry, 2012
Iron-sulfur (Fe-S) clusters are essential cofactors of proteins with a wide range of biological functions. A dedicated cytosolic Fe-S cluster assembly (CIA) system is required to assemble Fe-S clusters into cytosolic and nuclear proteins.
Lansdorp, Peter M., Morin, Gregg B., Moradian, Annie, Uringa, Evert-Jan, van Wietmarschen, Niek   +4 more
core   +3 more sources

TGF-beta/NF1/Smad4-mediated suppression of ANT2 contributes to oxidative stress in cellular senescence

Cellular Signalling, 2014
Oxidative stress and persistent activation of DNA damage response (DDR) are causally involved in the development of cellular senescence, a phenomenon implicated in fundamental (patho)physiological processes such as aging, fetal development and ...
Kollarovic, Gabriel, Luciakova, Katarina, Sabova, Ludmila, Bartek, Jiri, Hodny, Zdenek, Hubackova, Sona, Kretova, Miroslava, Nelson, Buck D.,   +7 more
core   +3 more sources

Casein kinase I epsilon interacts with mitochondrial proteins for the growth and survival of human ovarian cancer cells [PDF]

EMBO Molecular Medicine, 2012
Epithelial ovarian cancer is the leading cause of death among gynaecologic cancers in Western countries. Our studies have shown that casein kinase I‐epsilon (CKIε), a Wnt pathway protein, is significantly overexpressed in ovarian cancer tissues and is ...
Noah Rodriguez, Junzheng Yang, Kathleen Hasselblatt, Shubai Liu, Yilan Zhou, Jose A. Rauh‐Hain, Shu‐Kay Ng, Pui‐Wah Choi, Wing‐Ping Fong, Nathalie Y. R. Agar, William R. Welch, Ross S. Berkowitz, Shu‐Wing Ng   +12 more
doaj   +2 more sources

Down-regulation of ANT2 protein levels by shRNA from Targeting Adenine Nucleotide Translocase-2 (ANT2) to Overcome Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in Non–Small Cell Lung Cancer

, 2016
At 24 h after transfection with ANT2-specific shRNA or sc shRNA, Western blotting was performed to determine the levels of ANT2 and actin as a loading control.
Soo Jeong Nam (12357553), Ji-Young Jang (47189), Yoon Kyung Jeon (8605224), Bhumsuk Keam (77141), Tae Min Kim (7945694), Chul Woo Kim (15040407), Yong-goo Kim (15067773)   +6 more
core   +2 more sources

ETS2 aggravate allergic airway inflammation by regulating ANT2-mediated cytosolic mitochondrial DsRNA levels

Respiratory Research
Background ETS2 has been identified as a pivotal regulator in the development of human inflammatory diseases. Nevertheless, the functional aspects of ETS2 in asthma remain inadequately characterized. The release of mitochondrial dsRNA is recognized as an
Hui Jiang, Yaona Jiang, Ran Dong, Chang-Yong Fu   +3 more
doaj   +3 more sources

The roles of translocator protein (TSPO) and adenine nucleotide translocase 2 (ANT2) in breast cancer development and progression

, 2014
"This thesis research aims to investigate the functional roles of TSPO [translocator protein] and ANT2 [adenine nucleotide translocase 2] in breast cancer progression and assess their potential being therapeutic targets for breast cancer treatment ...
Wu, Xiaoting
core   +2 more sources

DataSheet1_Mitochondrial Respiration-Dependent ANT2-UCP2 Interaction.ZIP

, 2022
Adenine nucleotide translocases (ANTs) and uncoupling proteins (UCPs) are known to facilitate proton leak across the inner mitochondrial membrane. However, it remains to be unravelled whether UCP2/3 contribute to significant amount of proton leak in vivo.
Liza Löf (12628297), Radiosa Gallini (2937924), Tomas A. Schiffer (12628294), Masood Kamali-Moghaddam (203330), Fredrik Palm (317154), Mattias Carlström (5827283)   +5 more
core   +1 more source