Knockdown of ANT2 reduces adipocyte hypoxia and improves insulin resistance in obesity [PDF]
Nature Metabolism, 2019 Decreased adipose tissue oxygen tension and increased expression of the transcription factor hypoxia-inducible factor–1α (HIF-1α) can trigger adipose tissue inflammation and dysfunction in obesity.
Smith, Gordon I +12 more
core +7 more sources
The pleiotropic regulation of cyclin D1 by newly identified sesaminol-binding protein ANT2 [PDF]
Oncogenesis, 2017 The expression of cyclin D1 is upregulated in various cancer cells by diverse mechanisms, such as increases in mRNA levels, the promotion of the translation by mammalian target of rapamycin complex 1 (mTORC1) signaling and the protein stabilization.
M Watanabe +5 more
core +3 more sources
Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2 [PDF]
Cell Death & Differentiation, 2018 Cellular senescence is a form of cell cycle arrest that limits the proliferative potential of cells, including tumour cells. However, inability of immune cells to subsequently eliminate senescent cells from the organism may lead to tissue damage ...
LanFeng Dong +26 more
core +7 more sources
NF-κB regulates brown adipocyte function through suppression of ANT2
Acta Pharmaceutica Sinica B, 2022 The transcription factor nuclear factor of kappa-light-chain-enhancer of activated B cells (NF-κB) is expressed in brown adipocytes, but its role remains largely unknown in the cells.
Shiqiao Peng +10 more
doaj +3 more sources
A main factors affecting average number of teats in pigs [PDF]
Acta Fytotechnica et Zootechnica, 2016 The influence of factors (breed, year and season of farrowing, herd, parity order, sire of litter, total number of born piglets - TNB, number of piglets born alive - NBA, number of weaned piglets - NW, and linear and quadratic regression) on the number ...
Emil Krupa +2 more
doaj +3 more sources
Quel rôle spécifique pour ANT2 dans une cellule cancéreuse ? [PDF]
médecine/sciences, 2005 La translocase des nucléotides adényliques (ANT) réalise l’échange ATP/ADP entre le cytoplasme et la mitochondrie. Les isoformes ANT1 (musculaire) et ANT3 (ubiquitaire) exportent l’ATP produit par les phosphorylations oxydatives mitochondriales.
Stepien, Georges +5 more
core +3 more sources
ANT2 isoform required for cancer cell glycolysis
Journal of Bioenergetics and Biomembranes, 2005 International audienceThe three adenine nucleotide translocator (ANT1 to ANT3) isoforms, differentially expressed in human cells, play a crucial role in cell bioenergetics by catalyzing ADP and ATP exchange across the mitochondrial inner membrane.
Renier, Gilles +6 more
core +4 more sources
Advanced ScienceIntrinsic resistance limits chemo‐immunotherapy efficacy in triple‐negative breast cancer (TNBC). While metabolic reprogramming is linked to immune evasion, the precise mechanistic orchestration remains unclear.
Sen Zhong +20 more
doaj +2 more sources
Short-hairpin RNA-induced suppression of adenine nucleotide translocase-2 in breast cancer cells restores their susceptibility to TRAIL-induced apoptosis by activating JNK and modulating TRAIL receptor expression [PDF]
Molecular Cancer, 2010 Background Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL; apo2 ligand) induces apoptosis in cancer cells but has little effect on normal cells.
Kim Chul-Woo +3 more
doaj +2 more sources
PLoS ONE, 2013 Apo2 ligand (Apo2L)/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising cancer therapeutic agent. Recombinant human Apo2L/TRAIL has been under clinical trials, whereas various kinds of malignant tumors have resistance to Apo2L ...
Masakatsu Oishi +5 more
doaj +2 more sources