Results 41 to 50 of about 431 (145)

Antimicrobial Peptide TP4 Targets Mitochondrial Adenine Nucleotide Translocator 2

Marine Drugs, 2020
Tilapia piscidin (TP) 4 is an antimicrobial peptide derived from Nile tilapia (Oreochromis niloticus), which shows broad-spectrum antibacterial activity and excellent cancer-killing ability in vitro and in vivo.
Bor-Chyuan Su, Yi-Chung Liu, Chen-Hung Ting, Ping-Chiang Lyu, Jyh-Yih Chen   +4 more
doaj   +1 more source

Role of ANT2 in mitochondrial function and cancer cell survival: a target for therapeutic intervention

Cell Death Discovery
In summary, ANT2 is an important component of the mitochondrial machinery in PDAC cancer cells, which could be targeted pharmacologically. This warrants further investigation into the biological role of ANT2 in PDAC. Furthermore, our findings of potentiated effect between ANT2 disruption and OXPHOS inhibition by MitoTam suggest that this combination ...
Klara Bohacova, Zuzana Nahacka, Jana Dudova, Jaromira Kovarova, Jakub Rohlena, Michaela Rennerova, Barbora Judita Kasperova, Jan Stursa, Lukas Werner, Martin Haluzik, Jiri Neuzil, Sona Stemberkova Hubackova   +11 more
doaj   +4 more sources

Evaluation of in vivo antitumor effects of ANT2 shRNA delivered using PEI and ultrasound with microbubbles [PDF]

Gene Therapy, 2015
Gene therapy using RNA interference can be directed against tumors through various strategies, but has been hindered owing to the inefficiency of non-viral delivery. To evaluate the antitumor effects of adenine nucleotide translocase-2 (ANT2) short hairpin RNA (shRNA) by intraperitoneal injection using the polyethylenimine (PEI) and an ultrasound gene ...
D H, Park, B K, Jung, Y S, Lee, J Y, Jang, M K, Kim, J K, Lee, H, Park, J, Seo, C W, Kim   +8 more
openaire   +2 more sources

Effects of cadmium on oxidative stress and cell apoptosis in Drosophila melanogaster larvae

Scientific Reports, 2022
With the increase of human activities, cadmium (Cd) pollution has become a global environmental problem affecting biological metabolism in ecosystem. Cd has a very long half-life in humans and is excreted slowly in organs, which poses a serious threat to
Pingping Yang, Xingran Yang, Liran Sun, Xiaobing Han, Lu Xu, Wei Gu, Min Zhang   +6 more
doaj   +1 more source

Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta

Clinical Pharmacology &Therapeutics, EarlyView.
Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung, Nicholas Ieronimakis, Bothaina Mousa, Emily D. Sheikh, Sarah E. Ligon, Joshua W. Monson, Jennifer R. Damicis, Hillary J. Kinsman, Lydia E. Bettridge, Samuel L.M. Arnold, Edward J. Kelly, Jashvant D. Unadkat, Joanne Wang   +12 more
wiley   +1 more source

IF1 connects obesity and insulin resistance through mitochondrial reprogramming in association with ANT2 [PDF]

, 2020
Abstract IF1 (ATPIF1) is a nuclear DNA-encoded protein with an activity in the inhibition of catalytic activity of F 1 F o -ATP synthase (ATPase), an enzyme for ATP synthesis in mitochondria. A role of IF1 remains unknown in the metabolic disorder
Ying Wang, Yaya Guan, Jiaojiao Zhang, Xinyu Cao, Shuang Shen, Genshen Zhong, Xiwen Xong, Yanhong Xu, Xiaoying Zhang, Hui Wang, Jianping Ye   +10 more
openaire   +1 more source

Adenine nucleotide translocator and ATP synthase cooperate in mediating the mitochondrial permeability transition

The Journal of Physiology, EarlyView.
Abstract figure legend Both ATP synthase and adenine nucleotide translocator (ANT) play key roles in mediating the permeability transition. The contribution of ANT becomes evident in the presence of atractylate (ATR) at pH 6.5, a condition that prevents ATP synthase channel activity. At pH 7.4, this effect is minimal, suggesting a critical role for ATP
Ludovica Tommasin, Andrea Carrer, Federica Boscolo Nata, Elena Frigo, Federico Fogolari, Giovanna Lippe, Michela Carraro, Paolo Bernardi   +7 more
wiley   +1 more source

Suppression of adenine nucleotide translocase-2 by vector-based siRNA in human breast cancer cells induces apoptosis and inhibits tumor growth and [PDF]

, 2008
INTRODUCTION: Adenine nucleotide translocator (ANT) 2 is highly expressed in proliferative cells, and ANT2 induction in cancer cells is known to be directly associated with glycolytic metabolisms and carcinogenesis.
Choi, Yun, Ji-Young Jang, Yun Choi, Yoon-Kyung Jeon, Chul-Woo Kim, Kim, Chul-Woo, Jang, Ji-Young, Jeon, Yoon-Kyung   +7 more
core   +1 more source

ATP synthasome contributes to efficient energy flux in malignant breast cancer

Molecular Cancer
Background This study investigates the metabolic alterations associated with breast cancer progression and elucidates the underlying mechanisms. Adenine nucleotide translocase 2 (ANT2), a mitochondrial protein essential for cellular energy metabolism ...
Yen-Dun Tony Tzeng, Yu-Ting Kang, Tzu-Hung Hsiao, Pei-Yi Chu, Su-Boon Yong, Shih-Chieh Lin, Meng-Yu Wu, Ling-Ming Tseng, Ming-Feng Hou, Zhi-Hong Wen, Tzu-Sheng Hsu, Chih-Chiang Hung, An-Jen Chiang, Kuan-Hao Tsui, Chia-Jung Li   +14 more
doaj   +1 more source

Impaired Hepatic Glucose Metabolism Is Associated With Glucose Intolerance in Mice Carrying α2 Isoform Na,K‐ATPase Mutation

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Aim The Na,K‐ATPase is important for energy demanding cellular processes, including essential components of substrate metabolism and metabolic flexibility. Mice heterozygous for the hemiplegic migraine‐related mutation, G301R, of the Na,K‐ATPase α2 isoform (α2+/G301R) demonstrated altered metabolism in the heart.
Christian Staehr, Tue Duy Nguyen, Tina Myhre Pedersen, Mikkel Vendelbo, Hans Christian Beck, Mads Kjolby, Rajkumar Rajanathan, Elena V. Bouzinova, Niels Jessen, Per Bendix Jeppesen, Alexander V. Chibalin, Vladimir V. Matchkov   +11 more
wiley   +1 more source