Results 61 to 70 of about 431 (145)

Lysophosphatidic Acid Receptor 3 Promotes Mitochondrial Homeostasis against Oxidative Stress: Potential Therapeutic Approaches for Hutchinson–Gilford Progeria Syndrome

Antioxidants, 2022
Lysophosphatidic acid (LPA) is a growth factor-like lipid mediator that regulates various physiological functions via activation of multiple LPA G protein-coupled receptors.
Jui-Chung Chiang, Wei-Min Chen, Ciara Newman, Benjamin P. C. Chen, Hsinyu Lee   +4 more
doaj   +1 more source

CypD Dependent mPTP Opening Is Crucial for Oxidized Mitochondrial DNA Release in Ferroptosis

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Ferroptosis is driven by mitochondrial permeability transition pore (mPTP) opening, which induces mitochondrial swelling and releases oxidized mitochondrial DNA. The released mtDNA activates cGAS–STING signaling, promotes ferritinophagy, and amplifies ferroptotic cell death. Disruption of mtDNA repair sensitizes tumors to ferroptosis in vivo, revealing
Hong Zhou, Wan Fu, Shizuo Liu, Zili Zhang, Hanyan Luo, Qing Zhong   +5 more
wiley   +1 more source

From the cytosol to the inner membrane: biogenesis of the mitochondrial carrier family

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Mitochondrial carrier proteins are essential for cellular physiology as they are active in a wide range of metabolic pathways including production of cellular energy, amino acid synthesis, redox balance and ion homeostasis. The double membrane of mitochondria provides a tightly gated environment through which carrier proteins facilitate the ...
Catherine S. Palmer, Phoebe J. Leeming, Diana Stojanovski   +2 more
wiley   +1 more source

Exosomal miRNA-320a Is Released from hAMSCs and Regulates SIRT4 to Prevent Reactive Oxygen Species Generation in POI

Molecular Therapy: Nucleic Acids, 2020
Human amniotic mesenchymal stem cells (hAMSCs) were previously shown to effectively rescue ovarian function in a premature ovarian insufficiency (POI) mouse model.
Chenyue Ding, Chunfeng Qian, Shunyu Hou, Jiafeng Lu, Qinyan Zou, Hong Li, Boxian Huang   +6 more
doaj   +1 more source

Exercise training induces mitochondrial biogenesis, while high‐fat diet increases the ability of mitochondria to use long and short‐chain fatty acids

The Journal of Physiology, Volume 604, Issue 8, Page 3363-3378, 15 April 2026.
Abstract figure legend Despite a low baseline capacity for mitochondria to utilize short‐chain fatty acid (SCFA) to support oxidative phosphorylation, high‐fat diet (HFD) consumption rewired mitochondria to enhance both long‐chain and SCFA utilization, with these responses prevented by exercise training.
Jessica L. Dowling, Rachel M. Handy, Nicole M. Notaro, Sara M. Frangos, David J. Dyck, Graham P. Holloway   +5 more
wiley   +1 more source

Down-regulation of ANT2 and HSP90 mRNA levels by siRNA from Targeting Adenine Nucleotide Translocase-2 (ANT2) to Overcome Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in Non–Small Cell Lung Cancer

, 2016
H1975 cells were transfected with ANT siRNA, HSP90 siRNA or scramble (sc) siRNA. At 24 hours of transfection, expression levels of ANT2 and HSP90 were measured using qRT-PCR and the suppressive efficiency of siRNA was presented by relative expression ...
Soo Jeong Nam (12357553), Ji-Young Jang (47189), Yoon Kyung Jeon (8605224), Bhumsuk Keam (77141), Tae Min Kim (7945694), Chul Woo Kim (15040407), Yong-goo Kim (15067773)   +6 more
core   +1 more source

Deficiency in the mouse mitochondrial adenine nucleotide translocator isoform 2 gene is associated with cardiac noncompaction. [PDF]

, 2016
The mouse fetal and adult hearts express two adenine nucleotide translocator (ANT) isoform genes. The predominant isoform is the heart-muscle-brain ANT-isoform gene 1 (Ant1) while the other is the systemic Ant2 gene. Genetic inactivation of the Ant1 gene
Kokoszka, Jason E, Sweeney, Katelyn M, Angelin, Alessia, Flierl, Adrian, Wallace, Douglas C, Waymire, Katrina G, MacGregor, Grant R, MacGregor G. R., Kokoszka J. E., Flierl A., Angelin A., Wallace D. C., Waymire K. G., Sweeney K. M.   +13 more
core   +1 more source

Structural and Molecular Basis for Resistance to Aminoglycoside Antibiotics by the Adenylyltransferase ANT(2″)-Ia

mBio, 2015
The aminoglycosides are highly effective broad-spectrum antimicrobial agents. However, their efficacy is diminished due to enzyme-mediated covalent modification, which reduces affinity of the drug for the target ribosome.
Georgina Cox, Peter J. Stogios, Alexei Savchenko, Gerard D. Wright   +3 more
doaj   +1 more source

Senescent Cell Depletion Through Targeting BCL-Family Proteins and Mitochondria

Frontiers in Physiology, 2020
Senescent cells with replicative arrest can be generated during genotoxic, oxidative, and oncogenic stress. Long-term retention of senescent cells in the body, which is attributed to highly expressed BCL-family proteins, chronically damages tissues ...
Ying Fan, Ying Fan, Ying Fan, Jiaoqi Cheng, Jiaoqi Cheng, Huihong Zeng, Huihong Zeng, Lijian Shao, Lijian Shao, Lijian Shao   +9 more
doaj   +1 more source

The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic Significance

MedComm – Oncology, Volume 5, Issue 1, March 2026.
One‐Carbon metabolism in T‐cell activation and tumor competition. T‐cell activation shifts metabolic pathways, promoting anabolic metabolism and bioenergetic capacity. One‐carbon metabolism plays a crucial role in histone and DNA methylation in activated T cells.
Yuting Jiang, Guoliang Zhou, Qian Zhang, Shengtao Zhou   +3 more
wiley   +1 more source