Results 41 to 50 of about 353,387 (184)

ANT2-defective fibroblasts exhibit normal mitochondrial bioenergetics

Molecular Genetics and Metabolism Reports, 2015
Adenine nucleotide translocase 2 (ANT2) transports glycolytic ATP across the inner mitochondrial membrane. Patients with ANT2 deletion were recently reported. We aimed at characterizing mitochondrial functions in ANT2-defective fibroblasts.
Dolly Prabhu, Amy C. Goldstein, Riyad El-Khoury, Malgorzata Rak, Lia Edmunds, Pierre Rustin, Jerry Vockley, Manuel Schiff   +7 more
doaj   +1 more source

Atractyloside Protect Mice Against Liver Steatosis by Activation of Autophagy via ANT-AMPK-mTORC1 Signaling Pathway

Frontiers in Pharmacology, 2021
Objective: Adenine nucleotide translocase (ANT) can transport ADP from cytoplasm to mitochondrial matrix and provide raw materials for ATP synthesis by oxidative phosphorylation. Dysfunction of ANT leads to limitation of ADP transport and decrease of ATP
Pengfei Zhang, Xinyu Cheng, Huimin Sun, Yajing Li, Wuxuan Mei, Changchun Zeng   +5 more
doaj   +1 more source

Pioglitazone Is a Mild Carrier-Dependent Uncoupler of Oxidative Phosphorylation and a Modulator of Mitochondrial Permeability Transition

Pharmaceuticals, 2021
Pioglitazone (PIO) is an insulin-sensitizing antidiabetic drug, which normalizes glucose and lipid metabolism but may provoke heart and liver failure and chronic kidney diseases.
Ekaterina S. Kharechkina, Anna B. Nikiforova, Konstantin N. Belosludtsev, Tatyana I. Rokitskaya, Yuri N. Antonenko, Alexey G. Kruglov   +5 more
doaj   +1 more source

Mitochondrial adenine nucleotide translocase is modified oxidatively during aging [PDF]

Proceedings of the National Academy of Sciences, 1998
The purpose of this study was to test the hypothesis that elevation in protein oxidative damage during the aging process is a targeted rather than a stochastic phenomenon. Oxidative damage to proteins in mitochondrial membranes in the flight muscles of the housefly, manifested as carbonyl modifications, was detected ...
L J, Yan, R S, Sohal
openaire   +2 more sources

Cytosolic adaptation to mitochondria-induced proteostatic stress causes progressive muscle wasting

iScience, 2022
Summary: Mitochondrial dysfunction causes muscle wasting in many diseases and probably also during aging. The underlying mechanism is poorly understood. We generated transgenic mice with unbalanced mitochondrial protein loading and import, by moderately ...
Xiaowen Wang, Frank A. Middleton, Rabi Tawil, Xin Jie Chen   +3 more
doaj   +1 more source

Cofactor regeneration by a soluble pyridine nucleotide transhydrogenase for biological production of hydromorphone [PDF]

, 2000
We have applied the soluble pyridine nucleotide transhydrogenase of Pseudomonas fluorescens to a cell-free system for the regeneration of the nicotinamide cofactors NAD and NADP in the biological production of the important semisynthetic opiate drug ...
French, C E, Walker, E H, Bruce, N C, Rathbone, D A, Boonstra, B   +4 more
core   +1 more source

Mitochondrial protein IF1 is a potential regulator of glucagon-like peptide (GLP-1) secretion function of the mouse intestine

Acta Pharmaceutica Sinica B, 2021
IF1 (ATPIF1) is a nuclear DNA-encoded mitochondrial protein whose activity is inhibition of the F1Fo-ATP synthase to control ATP production. IF1 activity remains unknown in the regulation of GLP-1 activity.
Ying Wang, Jiaojiao Zhang, Xinyu Cao, Yaya Guan, Shuang Shen, Genshen Zhong, Xiwen Xiong, Yanhong Xu, Xiaoying Zhang, Hui Wang, Jianping Ye   +10 more
doaj   +1 more source

Chronic Intermittent Mild Whole-Body Hypothermia Is Therapeutic in a Mouse Model of ALS

Cells, 2021
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that causes motor neuron degeneration. There are no cures or effective treatments for ALS.
Lee J. Martin, Mark V. Niedzwiecki, Margaret Wong   +2 more
doaj   +1 more source

Human adenine nucleotide translocases physically and functionally interact with respirasomes

Molecular Biology of the Cell, 2017
Members of the adenine nucleotide translocase (ANT) family exchange ADP for ATP across the mitochondrial inner membrane, an activity that is essential for oxidative phosphorylation (OXPHOS). Mutations in or dysregulation of ANTs is associated with progressive external ophthalmoplegia, cardiomyopathy, nonsyndromic intellectual disability, apoptosis, and
Lu, Ya Wen, Acoba, Michelle Grace, Selvaraju, Kandasamy, Huang, Tai Chung, Nirujogi, Raja S., Sathe, Gajanan, Pandey, Akhilesh, Claypool, Steven M.   +7 more
openaire   +3 more sources

Over-expression of Adenine Nucleotide Translocase 1 (ANT1) Induces Apoptosis and Tumor Regression in vivo

BMC Cancer, 2008
Background Adenine nucleotide translocase (ANT) is located in the inner mitochondrial membrane and catalyzes the exchange of mitochondrial ATP for cytosolic ADP.
Kim Chul-Woo, Aung Khin, Jeon Yoon-Kyung, Choi Yun, Jang Ji-Young   +4 more
doaj   +1 more source