Mitochondrial Permeability Transition Pore: The Cardiovascular Disease’s Molecular Achilles Heel [PDF]
BiomedicinesThe mitochondrial permeability transition pore (mPTP) plays a central role in myocardial injury. Upon reperfusion after myocardial infarction, oxidative stress, calcium overload, and ATP depletion promote mPTP opening, leading to mitochondrial ...
Salvatore Nesci, Speranza Rubattu
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The Haves and Have-Nots: The Mitochondrial Permeability Transition Pore across Species [PDF]
Cells, 2023 The demonstration that F1FO (F)-ATP synthase and adenine nucleotide translocase (ANT) can form Ca2+-activated, high-conductance channels in the inner membrane of mitochondria from a variety of eukaryotes led to renewed interest in the permeability ...
Elena Frigo +4 more
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SARS-COV-2 viroporins activate the NLRP3-inflammasome by the mitochondrial permeability transition pore [PDF]
Frontiers in Immunology, 2023 BackgroundCompared to healthy controls, severe COVID19 patients display increased levels of activated NLRP3-inflammasome (NLRP3-I) and interleukin (IL)-1β. SARS-CoV-2 encodes viroporin proteins E and Orf3a(2-E+2-3a) with homologs to SARS-CoV-1, 1-E+1-3a,
Joseph W. Guarnieri +9 more
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The Mitochondrial Permeability Transition Pore in Platelets: Mechanisms, Physiological Roles, and Therapeutic Perspectives [PDF]
AntioxidantsPlatelets have long been known to be critically involved in hemostasis and thrombosis. However, platelets are also recognized as metabolically active cells that require well-regulated mitochondrial function to support their multiple functions in ...
Chiara Lonobile +4 more
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Mitochondrial 8-Oxoguanine DNA Glycosylase 1–Mitochondrial Permeability Transition Pore Axis Drives Mitochondrial DNA Escape and Accelerates Osteoarthritis Progression [PDF]
ResearchMitochondrial DNA (mtDNA) damage and its subsequent release into the cytoplasm are strongly linked to osteoarthritis (OA), but the pathogenic mechanism remains poorly understood.
Shiqian Huang +11 more
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The mitochondrial ATP synthase is a negative regulator of the mitochondrial permeability transition pore [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2023 Pablo M Peixoto +2 more
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The Mitochondrial Permeability Transition Pore—Current Knowledge of Its Structure, Function, and Regulation, and Optimized Methods for Evaluating Its Functional State [PDF]
Cells, 2023 Zuzana Červinková +2 more
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Neural Regeneration Research, 2023 The mitochondrial permeability transition pore is a nonspecific transmembrane channel. Inhibition of mitochondrial permeability transition pore opening has been shown to alleviate mitochondrial swelling, calcium overload, and axonal degeneration ...
Yang Yang +12 more
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Frontiers in Cell and Developmental Biology, 2023 Acute lymphoblastic leukemia (aLL) is a malignant cancer in the blood and bone marrow characterized by rapid expansion of lymphoblasts. It is a common pediatric cancer and the principal basis of cancer death in children.
Jung Kwon Lee +2 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background The opening of mitochondrial permeability transition pore and inflammation cooperatively progress myocardial ischemia‐reperfusion (IR) injury, which hampers therapeutic effects of primary reperfusion therapy for acute myocardial infarction. We
Gentaro Ikeda +7 more
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