Antamanide, a derivative of Amanita phalloides, is a novel inhibitor of the mitochondrial permeability transition pore. [PDF]
PLoS ONE, 2011 Antamanide is a cyclic decapeptide derived from the fungus Amanita phalloides. Here we show that antamanide inhibits the mitochondrial permeability transition pore, a central effector of cell death induction, by targeting the pore regulator cyclophilin D.
Luca Azzolin +8 more
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Edaravone, a Radical Scavenger, Inhibits Mitochondrial Permeability Transition Pore in Rat Brain
Journal of Pharmacological Sciences, 2007 Edaravone, a radical scavenger, prevents ischemia/reperfusion injury in the brain, but the detailed mechanism is not known. This study examines the effect of edaravone on mitochondrial permeability transition pore (PTP) in rat brain.
Yuko Takayasu +6 more
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The mitochondrial permeability transition pore: A mystery solved? [PDF]
Frontiers in Physiology, 2013 The permeability transition denotes an increase of the mitochondrial inner membrane permeability to solutes with molecular masses up to about 1,500 Da. It is presumed to be mediated by opening of a channel, the permeability transition pore (PTP), whose ...
Paolo eBernardi, Paolo eBernardi
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Toxic Effects of Unripe Carica papaya (Linn) Fruit Extract on Healthy Rat Liver Mitochondria
Traditional and Integrative Medicine, 2021 The opening of the mitochondrial Permeability Transition (mPT) pore proceeds the activation of programmed cell death (apoptosis) and its functional status serves as marker of mitochondrial health.
Olubukola T Oyebode +2 more
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Loss of DJ-1 does not affect mitochondrial respiration but increases ROS production and mitochondrial permeability transition pore opening. [PDF]
PLoS ONE, 2012 Loss of function mutations in the DJ-1 gene have been linked to recessively inherited forms of Parkinsonism. Mitochondrial dysfunction and increased oxidative stress are thought to be key events in the pathogenesis of Parkinson's disease. Although it has
Emilie Giaime +4 more
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The Role of Adenine Nucleotide Translocase in the Mitochondrial Permeability Transition
Cells, 2020 The mitochondrial permeability transition, a Ca2+-induced significant increase in permeability of the inner mitochondrial membrane, plays an important role in various pathologies.
Nickolay Brustovetsky
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Methanol extract and fraction of Anchomanes difformis root tuber modulate liver mitochondrial membrane permeability transition pore opening in rats [PDF]
Avicenna Journal of Phytomedicine, 2020 Objective: Extracts of Anchomanes difformis (AD) are used in folkloric medicine to treat several diseases and infections. However, their roles in mitochondrial permeability transition pore opening are not known.
Oludele Olanlokun +2 more
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Cannabidiol activates PINK1-Parkin-dependent mitophagy and mitochondrial-derived vesicles
European Journal of Cell Biology, 2022 The PINK1/Parkin pathway plays an important role in maintaining a healthy pool of mitochondria. Activation of this pathway can lead to apoptosis, mitophagy, or mitochondrial-derived vesicle formation, depending on the nature of mitochondrial damage.
Adrian Ramirez +3 more
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Both ANT and ATPase are essential for mitochondrial permeability transition but not depolarization
iScience, 2022 Summary: An increase in permeability of the mitochondrial inner membrane, mitochondrial permeability transition (PT), is the central event responsible for cell death and tissue damage in conditions such as stroke and heart attack.
M.A. Neginskaya +2 more
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Biochemistry Research International, 2020 Mitochondrial permeability transition is characterized by the opening of a transmembranal pore that switches membrane permeability from specific to nonspecific.
Edmundo Chávez +5 more
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