Results 31 to 40 of about 3,189,303 (248)

PKCε and cardioprotection : an exploration of putative mechanisms [PDF]

, 2006
Includes bibliographical references.Recent studies have investigated the underlying regulatory mechanisms that may explain the cardioprotective role of PKCε.
McCarthy, Joy
core   +1 more source

The obesity-related peptide leptin sensitizes cardiac mitochondria to calcium-induced permeability transition pore opening and apoptosis. [PDF]

PLoS ONE, 2012
The obesity-related 16 kDa peptide leptin is synthesized primarily in white adipocytes although its production has been reported in other tissues including the heart.
Eduardo Martinez-Abundis, Venkatesh Rajapurohitam, James V Haist, Xiaohong T Gan, Morris Karmazyn   +4 more
doaj   +1 more source

Mitochondrial permeability transition, F1FO-ATPase and calcium: An enigmatic triangle [PDF]

, 2017
In response to calcium mitochondria can undergo a permeability transition—a sudden increase of the permeability of the inner mitochondrial membrane to ions and solutes resulting in cell death.
Salvatore Nesci, NESCI, SALVATORE
core   +1 more source

Unlocking the Door to Neuronal Woes in Alzheimer’s Disease: Aβ and Mitochondrial Permeability Transition Pore

Pharmaceuticals, 2010
Mitochondrial dysfunction occurs early in the progression of Alzheimer’s disease. Amyloid-β peptide has deleterious effects on mitochondrial function and contributes to energy failure, respiratory chain impairment, neuronal apoptosis, and generation of ...
Heng Du, Shirley ShiDu Yan
doaj   +1 more source

Mitochondrial Permeability Transition: A Pore Intertwines Brain Aging and Alzheimer’s Disease

Cells, 2021
Advanced age is the greatest risk factor for aging-related brain disorders including Alzheimer’s disease (AD). However, the detailed mechanisms that mechanistically link aging and AD remain elusive.
Kun Jia, Heng Du
doaj   +1 more source

Mitochondrial translocation of vitamin D receptor is mediated by the permeability transition pore in human keratinocyte cell line. [PDF]

PLoS ONE, 2013
BACKGROUND: Vitamin D receptor (VDR) is a well known transcriptional regulator, active as heterodimer in association with coactivators and corepressors. In addition it has been described the extranuclear distribution of the receptor and in particular the
Francesca Silvagno, Marco Consiglio, Valentina Foglizzo, Michele Destefanis, Gianpiero Pescarmona   +4 more
doaj   +1 more source

Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice

eLife, 2013
A critical event in ischemia-based cell death is the opening of the mitochondrial permeability transition pore (MPTP). However, the molecular identity of the components of the MPTP remains unknown.
Jason Karch, Jennifer Q Kwong, Adam R Burr, Michelle A Sargent, John W Elrod, Pablo M Peixoto, Sonia Martinez-Caballero, Hanna Osinska, Emily H-Y Cheng, Jeffrey Robbins, Kathleen W Kinnally, Jeffery D Molkentin   +11 more
doaj   +1 more source

The mitochondrial permeability transition pore components [PDF]

, 2010
The mitochondrial permeability transition pore (MPTP) is a non-specific channel in the inner mitochondrial membrane (IMM) that opens following ischaemia and reperfusion due to the presence of various stimuli, such as oxidative stress, elevated phosphate ...
Mohar, Zoltan
core   +1 more source

Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization

International Journal of Cell Biology, 2010
During apoptosis, the process of mitochondrial outer membrane permeabilization (MOMP) represents a point-of-no-return as it commits the cell to death.
Sanjeev Gupta, Lorraine Cuffe, Eva Szegezdi, Susan E. Logue, Catherine Neary, Sandra Healy, Afshin Samali   +6 more
doaj   +1 more source

Menadione-induced apoptosis: roles of cytosolic Ca(2+) elevations and the mitochondrial permeability transition pore

, 2002
In normal pancreatic acinar cells, the oxidant menadione evokes repetitive cytosolic Ca(2+) spikes, partial mitochondrial depolarisation, cytochrome c release and apoptosis.
Tepikin, Alexei V., Gerasimenko, Julia V., Petersen, Ole Holger, Petersen, Ole H., Tepikin, Alexei, Gerasimenko, Oleg V., Palejwala, Altaf, Watson, Alistair J. M., Gerasimenko, Julia Vladimirovna, Watson, Alastair J. M., Gerasimenko, Oleg Vsevolodovich   +10 more
core   +5 more sources