Results 41 to 50 of about 3,189,303 (248)

Mitochondrial permeability transition pore and cancer: molecular mechanisms involved in cell death

Frontiers in Oncology, 2014
Since its discovery in the 1970s, the mitochondrial permeability transition has been proposed to be a strategic regulator of cell death. Intense research efforts have focused on elucidating the molecular components of the mitochondrial permeability ...
Paolo ePinton, Massimo eBonora
doaj   +1 more source

Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection [PDF]

, 2004
Background - Transient (low-conductance) opening of the mitochondrial permeability transition pore (mPTP) may limit mitochondrial calcium load and mediate mitochondrial reactive oxygen species (ROS) signaling.
Wynne, A, Duchen, M, Yellon, D, Hausenloy, D   +3 more
core  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Closing the Mitochondrial Permeability Transition Pore in hiPSC-Derived Endothelial Cells Induces Glycocalyx Formation and Functional Maturation

Stem Cell Reports, 2019
Summary: Human induced pluripotent stem cells (hiPSCs) are used to study organogenesis and model disease as well as being developed for regenerative medicine.
Gesa L. Tiemeier, Gangqi Wang, Sébastien J. Dumas, Wendy M.P.J. Sol, M. Cristina Avramut, Tobias Karakach, Valeria V. Orlova, Cathelijne W. van den Berg, Christine L. Mummery, Peter Carmeliet, Bernard M. van den Berg, Ton J. Rabelink   +11 more
doaj   +1 more source

Mitochondrial toxicity of organic arsenicals: membrane permeability transition pore opening and respiratory dysfunction

, 2018
Organic arsenicalMOPIMPinduced mitochondrial membrane permeability transition pore opening, respiration suppression and metabolic thermogenesis dysfunction in isolated mitochondria.
Can Wu, Xiao-Yang Fan, Lian Yuan, Yu-Jiao Liu, Yan-Jun Hu, Feng-Lei Jiang, Yi Liu   +6 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

CaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulation

Nature Communications, 2016
β-adrenergic receptor signaling induces mitochondrial permeability transition pore (mPTP) opening. Here, Xuet al. show that this effect is mediated by phosphorylation of mitochondrial fission protein Drp1 by CamKII, which increases the frequency of ...
Shangcheng Xu, Pei Wang, Huiliang Zhang, Guohua Gong, Nicolas Gutierrez Cortes, Weizhong Zhu, Yisang Yoon, Rong Tian, Wang Wang   +8 more
doaj   +1 more source

Measurement of membrane permeability and the mitochondrial permeability transition

, 2020
The mitochondrial permeability transition (PT) is an increase in the inner membrane permeability caused by the opening of a Ca2 +-activated high-conductance channel, the so-called PT pore (PTP) or mitochondrial megachannel (MMC).
Carraro M., Michela Carraro, Paolo Bernardi, Bernardi P.   +3 more
core   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source