Results 61 to 70 of about 370,851 (253)

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

Advanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li, Kuanhui Gao, Mengjie Wang, Songlin Liang, Dandan Li, Guoqing Tan, Haipeng Xue, Yujie Liu, Peng Zhang, Zhanwang Xu, Wenxiang Cheng, Yongjun Wang, Nianhu Li   +12 more
wiley   +1 more source

Rational Molecular Design to Improve Digital Polymer Readout in Aerolysin‐Based Nanopore Sequencing

Angewandte Chemie, EarlyView.
Nanopore sensing holds significant yet underexplored potential for decoding synthetic digital polymers. In this study, we synthesized an extensive library of sequence‐defined poly(phosphodiester)s and evaluated their performance in aerolysin‐based sequencing. By systematically optimizing molecular parameters, we identified an ideal combination of coded
Zhaozheng Yang, Juan Francisco Bada Juarez, Georgette Obeid, Alissa Agerova, Thomas R. Bryner, Davide Cois, Maria J. Marcaida, Chan Cao, Matteo Dal Peraro, Jean‐François Lutz   +9 more
wiley   +2 more sources

L-Arginine Intake Effect on Adenine Nucleotide Metabolism in Rat Parenchymal and Reproductive Tissues

The Scientific World Journal, 2012
L-arginine is conditionally essetcial amino acid, required for normal cell growth, protein synthesis, ammonia detoxification, tissue growth and general performance, proposed in the treatment of men sterility and prevention of male impotence.
G. Kocic, J. Nikolic, T. Jevtovic-Stoimenov, D. Sokolovic, H. Kocic, T. Cvetkovic, D. Pavlovic, A. Cencic, D. Stojanovic   +8 more
doaj   +1 more source

Acyclic nucleoside phosphonates with adenine nucleobase inhibit Trypanosoma brucei adenine phosphoribosyltransferase in vitro

Scientific Reports, 2021
All medically important unicellular protozoans cannot synthesize purines de novo and they entirely rely on the purine salvage pathway (PSP) for their nucleotide generation.
Eva Doleželová, Tomáš Klejch, Petr Špaček, Martina Slapničková, Luke Guddat, Dana Hocková, Alena Zíková   +6 more
doaj   +1 more source

Xenopus adenine nucleotide translocase mRNA exhibits specific and dynamic patterns of expression during development

, 2000
We report the isolation and characterization of the Xenopus homolog to human T1 ANT (adenine nucleotide translocase). The 1290-nucleotide sequence contains initiation and termination signals, and encodes a conceptual protein of 298 amino acids.
Michael J Crawford, Varmuza, Susannah L., Liversage, Richard A., Farhad KhosrowShahian, Richard A Liversage, KhosrowShahian, Farhad, Susannah L Varmuza, Crawford, Michael J   +7 more
core   +1 more source

Raman Analysis of RNA Nucleotide Strands From SARS‐CoV‐2 Variants and Subvariants: A Step Forward in the Definition of “Raman Genome”

Advanced Science, EarlyView.
Main Raman signals in RNA, related to helical backbone, ribofuranose ring, and nitrogenous bases, are affected by secondary structures that cause hyperchromic effects and significantly alter the Raman intensity. ABSTRACT Raman spectra of RNA nucleotide strands extracted from 20 SARS‐CoV‐2 strains, including the original Japanese isolate, Alpha, Beta ...
Giuseppe Pezzotti, Yoshiki Yasukochi, Gianluca Angiola, Takaharu Ueno, Saki Ikegami, Rintaro Okawa, Tetsuya Adachi, Wenliang Zhu, Osam Mazda, Alfio Grillo, Koichiro Higasa, Kazu Okuma   +11 more
wiley   +1 more source

Prolonged adenine nucleotide resynthesis and reperfusion injury in postischemic skeletal muscle

, 1992
Skeletal muscle ischemia results in energy depletion and intracellular acidosis. Reperfusion is associated with impaired adenine nucleotide resynthesis, edema formation, and myocyte necrosis. The purpose of these studies was to define the time course of
J. Tittley, B. B. Rubin, S. Liauw, A. D. Romaschin, P. M. Walker   +4 more
core   +1 more source

CRISPR and Gene Augmentation Rescue Trabecular Meshwork Dysfunction in iPSC Models of Lowe Syndrome

Advanced Science, EarlyView.
By modeling Lowe syndrome using patient‐derived iPSCs, this study establishes a human disease model that faithfully recapitulates OCRL deficiency‐associated ciliary and cytoskeletal defects. The model enables evaluation of both mutation‐agnostic DNA augmentation and CRISPR‐mediated mutation correction strategies, both of which restore OCRL function and
Siyu Chen, Zhiquan Liu, Wenmin Wang, Qing Wang, Tia J. Kowal, Fan Zhang, Grzegorz Walkiewicz, Faruk Hossen, Herbert M. Lachman, Jinqiong Zhou, Yiting Wang, Yang Sun   +11 more
wiley   +1 more source

ДНК как модулятор протонной проницаемости на внутренней мембране митохондрий Solanum tuberosum, действующий на уровне переносчика адениннуклеотидов

Фактори експериментальної еволюції організмів, 2014
Aims. To study the potential metabolic consequences of DNA import into mitochondria we investigated the effect of 200 bp length DNA on the permeability of inner membrane of tuber mitochondria in Solanum tuberosum in comparison with such an effect of ...
М. В. Кулинченко, Е. С. Клименко, Ф. Вебер-Лотфи, А. Диетриш, Ю. М. Константинов   +4 more
doaj  

An ATP7A‐Mediated Endogenous Regulation Bio‐Clay Enzyme Enables Self‐Amplified Copper Accumulation for Immunogenic Pyrop

Advanced Science, EarlyView.
A self‐amplifying bio‐clay nanozyme (Bio‐Clayzyme) disrupts tumor metabolic homeostasis through endogenous copper transporter ATPase (ATP7A) downregulation, enhancing cascade catalysis and triggering immunogenic pyroptosis for effective tumor immunotherapy.
Weimin Xie, Yan Li, Guangyao Li, Ying Chen, Huaming Yang   +4 more
wiley   +1 more source