Results 11 to 20 of about 102,948 (256)

CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module [PDF]

Nature Communications, 2020
The mechanism by which adenosine monophosphate modulates dynein ATPase-mediated ciliary and flagellar beating remains obscure. Here the authors identify an axonemal module including cilia and flagella associated protein 45 that supports adenine ...
Gerard W. Dougherty, Katsutoshi Mizuno, Tabea Nöthe-Menchen, Yayoi Ikawa, Karsten Boldt, Asaf Ta-Shma, Isabella Aprea, Katsura Minegishi, Yuan-Ping Pang, Petra Pennekamp, Niki T. Loges, Johanna Raidt, Rim Hjeij, Julia Wallmeier, Huda Mussaffi, Zeev Perles, Orly Elpeleg, Franziska Rabert, Hidetaka Shiratori, Stef J. Letteboer, Nicola Horn, Samuel Young, Timo Strünker, Friederike Stumme, Claudius Werner, Heike Olbrich, Katsuyoshi Takaoka, Takahiro Ide, Wang Kyaw Twan, Luisa Biebach, Jörg Große-Onnebrink, Judith A. Klinkenbusch, Kavita Praveen, Diana C. Bracht, Inga M. Höben, Katrin Junger, Jana Gützlaff, Sandra Cindrić, Micha Aviram, Thomas Kaiser, Yasin Memari, Petras P. Dzeja, Bernd Dworniczak, Marius Ueffing, Ronald Roepman, Kerstin Bartscherer, Nicholas Katsanis, Erica E. Davis, Israel Amirav, Hiroshi Hamada, Heymut Omran   +50 more
doaj   +2 more sources

CoCl₂-Mimicked Endothelial Cell Hypoxia Induces Nucleotide Depletion and Functional Impairment That Is Reversed by Nucleotide Precursors

Biomedicines, 2022
Chronic hypoxia drives vascular dysfunction by various mechanisms, including changes in mitochondrial respiration. Although endothelial cells (ECs) rely predominantly on glycolysis, hypoxia is known to alter oxidative phosphorylation, promote oxidative ...
Barbara Kutryb-Zajac, Ada Kawecka, Alicja Braczko, Marika Franczak, Ewa M. Slominska, Roberto Giovannoni, Ryszard T. Smolenski   +6 more
doaj   +1 more source

Absence of Ca2+-induced mitochondrial permeability transition but presence of bongkrekate-sensitive nucleotide exchange in C. crangon and P. serratus. [PDF]

PLoS ONE, 2012
Mitochondria from the embryos of brine shrimp (Artemia franciscana) do not undergo Ca(2+)-induced permeability transition in the presence of a profound Ca(2+) uptake capacity. Furthermore, this crustacean is the only organism known to exhibit bongkrekate-
Csaba Konrad, Gergely Kiss, Beata Torocsik, Vera Adam-Vizi, Christos Chinopoulos   +4 more
doaj   +1 more source

Selective killing of tumors deficient in methylthioadenosine phosphorylase: a novel strategy. [PDF]

PLoS ONE, 2009
BACKGROUND:The gene for methylthioadenosine phosphorylase (MTAP) lies on 9p21, close to the gene CDKN2A that encodes the tumor suppressor proteins p16 and p14ARF.
Martin Lubin, Adam Lubin
doaj   +1 more source

Functional expression of human adenine nucleotide translocase 4 in Saccharomyces cerevisiae. [PDF]

PLoS ONE, 2011
The adenine nucleotide translocase (ANT) mediates the exchange of ADP and ATP across the inner mitochondrial membrane. The human genome encodes multiple ANT isoforms that are expressed in a tissue-specific manner.
Takashi Hamazaki, Wai-Yee Leung, Brian D Cain, David A Ostrov, Peter E Thorsness, Naohiro Terada   +5 more
doaj   +1 more source

Adenine Nucleotide and Nicotinamide Adenine Dinucleotide Measurements in Plants [PDF]

Current Protocols in Plant Biology, 2020
AbstractAs the principal co‐factors of many metabolic pathways, the measurement of both adenine nucleotides and nicotinamide adenine dinucleotide provides important information about cellular energy metabolism. However, given their rapid and reversible conversion as well as their relatively low concentration ranges, it is difficult to measure these ...
Zhang, Youjun, Krahnert, Ina, Bolze, Antje, Gibon, Yves, Fernie, Alisdair   +4 more
openaire   +4 more sources

The evolution of purinergic receptors involved in recognition of a blood meal by hematophagous insects

Memorias do Instituto Oswaldo Cruz, 1987
Many blood feeders use adenine nucleotides as cues for locating blood meal. Structure-activity relationship of adenine nucleotides as phagostimulants varies between closely-related species of blood feeders. It is suggested that a preexisting diverse pool
Rachel Galun
doaj   +1 more source

Adenine nucleotide translocator transports haem precursors into mitochondria.

PLoS ONE, 2008
Haem is a prosthetic group for haem proteins, which play an essential role in oxygen transport, respiration, signal transduction, and detoxification.
Motoki Azuma, Yasuaki Kabe, Chikanori Kuramori, Masao Kondo, Yuki Yamaguchi, Hiroshi Handa   +5 more
doaj   +1 more source

Lack of Association Between Toll-like Receptor 2 Polymorphisms (R753Q and A-16934T) and Atopic Dermatitis in Children from Thrace Region of Turkey

Balkan Medical Journal, 2017
Background: Atopic dermatitis is the most common chronic inflammatory skin disease. A complex interaction of both genetic and environmental factors is thought to contribute to the disease. Aims: To evaluate whether single nucleotide polymorphisms in the
Ceren Can, Mehtap Yazıcıoğlu, Hakan Gürkan, Hilmi Tozkır, Adnan Görgülü, Necdet Hilmi Süt   +5 more
doaj   +1 more source

Growth performance and some related growth genes expression for some native layer and hybrid broiler chicken breeds [PDF]

Benha Veterinary Medical Journal, 2022
This research was carried out to evaluate the difference in the  mRNA  genetic expression of  the  liver genes as  adenine nucleotide translocase (ANT), cytochrome  oxidase subunit III (COX III),  Insulin like growth factor binding protein 2 (IGFBp2) and 
Samar Hosny Baloza, Fatma El-gendy
doaj   +1 more source