Adenine Nucleotide and Nicotinamide Adenine Dinucleotide Measurements in Plants [PDF]
AbstractAs the principal co‐factors of many metabolic pathways, the measurement of both adenine nucleotides and nicotinamide adenine dinucleotide provides important information about cellular energy metabolism. However, given their rapid and reversible conversion as well as their relatively low concentration ranges, it is difficult to measure these ...
Zhang, Youjun+4 more
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Selective killing of tumors deficient in methylthioadenosine phosphorylase: a novel strategy. [PDF]
BACKGROUND:The gene for methylthioadenosine phosphorylase (MTAP) lies on 9p21, close to the gene CDKN2A that encodes the tumor suppressor proteins p16 and p14ARF.
Martin Lubin, Adam Lubin
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Functional expression of human adenine nucleotide translocase 4 in Saccharomyces cerevisiae. [PDF]
The adenine nucleotide translocase (ANT) mediates the exchange of ADP and ATP across the inner mitochondrial membrane. The human genome encodes multiple ANT isoforms that are expressed in a tissue-specific manner.
Takashi Hamazaki+5 more
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Adenine nucleotide translocator transports haem precursors into mitochondria.
Haem is a prosthetic group for haem proteins, which play an essential role in oxygen transport, respiration, signal transduction, and detoxification.
Motoki Azuma+5 more
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Many blood feeders use adenine nucleotides as cues for locating blood meal. Structure-activity relationship of adenine nucleotides as phagostimulants varies between closely-related species of blood feeders. It is suggested that a preexisting diverse pool
Rachel Galun
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Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons [PDF]
Mutations in the gene encoding valosin-containing protein (VCP) lead to multisystem proteinopathies including frontotemporal dementia. We have previously shown that patient-derived VCP mutant fibroblasts exhibit lower mitochondrial membrane potential ...
Abramov+43 more
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Conformationally Restricted Adenine Nucleotide Analogs in Mitochondrial Adenine Nucleotide Transport
Abstract The conformationally restricted adenine nucleotide analogs 8,3′anhydro-8-oxy-9-(β-ᴅ-xylofurano-syl) adenine-5′-O-tri (di) -phosphate (I) , and 8,2′-anhydro-8-oxy-9-(β-ᴅ-arabinofuranosyl) adenine-5′-O-tri (di)-phosphate (II), were prepared chemically as their α-32P-labelled compounds and compared with syn-structured 8-bromo AT(D)
Morio Ikehara+2 more
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Trypanosoma brucei methylthioadenosine phosphorylase protects the parasite from the antitrypanosomal effect of deoxyadenosine [PDF]
Trypanosoma brucei causes African sleeping sickness for which no vaccine exists and available treatments are of limited use due to their high toxicity or lack of efficacy. T.
de Koning, Harry P.+4 more
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Background: Atopic dermatitis is the most common chronic inflammatory skin disease. A complex interaction of both genetic and environmental factors is thought to contribute to the disease. Aims: To evaluate whether single nucleotide polymorphisms in the
Ceren Can+5 more
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Can adenine nucleotides predict primary nonfunction of the human liver homograft? [PDF]
Sixty-eight primary liver grafts were analyzed to see whether adenine nucleotides (AN: ATP, ADP, and AMP) or purine catabolites (PC: adenosine, inosine, hypoxanthine, and xanthine) of tissue or effluent can predict primary graft nonfunction.
Bronsther, O+8 more
core +1 more source