Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons [PDF]
, 2017 Mutations in the gene encoding valosin-containing protein (VCP) lead to multisystem proteinopathies including frontotemporal dementia. We have previously shown that patient-derived VCP mutant fibroblasts exhibit lower mitochondrial membrane potential ...
Abramov +43 more
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Memorias do Instituto Oswaldo Cruz, 1987 Many blood feeders use adenine nucleotides as cues for locating blood meal. Structure-activity relationship of adenine nucleotides as phagostimulants varies between closely-related species of blood feeders. It is suggested that a preexisting diverse pool
Rachel Galun
doaj +1 more source
Adenine nucleotide translocator transports haem precursors into mitochondria.
PLoS ONE, 2008 Haem is a prosthetic group for haem proteins, which play an essential role in oxygen transport, respiration, signal transduction, and detoxification.
Motoki Azuma +5 more
doaj +1 more source
DGR mutagenic transposition occurs via hypermutagenic reverse transcription primed by nicked template RNA. [PDF]
, 2017 Diversity-generating retroelements (DGRs) are molecular evolution machines that facilitate microbial adaptation to environmental changes. Hypervariation occurs via a mutagenic retrotransposition process from a template repeat (TR) to a variable repeat ...
Guo, Huatao +6 more
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Deconvoluting AMP-activated protein kinase (AMPK) adenine nucleotide binding and sensing
Journal of Biological Chemistry, 2017 AMP-activated protein kinase (AMPK) is a central cellular energy sensor that adapts metabolism and growth to the energy state of the cell. AMPK senses the ratio of adenine nucleotides (adenylate energy charge) by competitive binding of AMP, ADP, and ATP ...
X. Gu +13 more
semanticscholar +1 more source
Balkan Medical Journal, 2017 Background: Atopic dermatitis is the most common chronic inflammatory skin disease. A complex interaction of both genetic and environmental factors is thought to contribute to the disease. Aims: To evaluate whether single nucleotide polymorphisms in the
Ceren Can +5 more
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Trypanosoma brucei methylthioadenosine phosphorylase protects the parasite from the antitrypanosomal effect of deoxyadenosine [PDF]
, 2016 Trypanosoma brucei causes African sleeping sickness for which no vaccine exists and available treatments are of limited use due to their high toxicity or lack of efficacy. T.
de Koning, Harry P. +4 more
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Human adenine nucleotide translocases physically and functionally interact with respirasomes
Molecular Biology of the Cell, 2017 A network of interactions for human adenine nucleotide translocases, required for oxidative phosphorylation, is reported. Of particular interest is an evolutionarily conserved and functionally important association with respiratory supercomplexes, which ...
Ya-Wen Lu +7 more
semanticscholar +1 more source
Nucleotides: Structure and Properties [PDF]
, 2005 Nucleotides consist of a nitrogen-containing base, a five-carbon sugar, and one or more phosphate groups. Cells contain many types of nucleotides, which play a central role in a wide variety of cellular processes, including metabolic regulation and the ...
Bowater, RP
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Conformationally Restricted Adenine Nucleotide Analogs in Mitochondrial Adenine Nucleotide Transport
Zeitschrift für Naturforschung C, 1978 Abstract The conformationally restricted adenine nucleotide analogs 8,3′anhydro-8-oxy-9-(β-ᴅ-xylofurano-syl) adenine-5′-O-tri (di) -phosphate (I) , and 8,2′-anhydro-8-oxy-9-(β-ᴅ-arabinofuranosyl) adenine-5′-O-tri (di)-phosphate (II), were prepared chemically as their α-32P-labelled compounds and compared with syn-structured 8-bromo AT(D)
K S, Boos, E, Schlimme, M, Ikehara
openaire +2 more sources