Results 131 to 140 of about 708,526 (362)

Exploring RNA G‐Quadruplex Stability in the Gas Phase: Insights from Native Mass Spectrometry

open access: yesChemPlusChem, EarlyView.
This study explores RNA G‐quadruplex structures using native mass spectrometry to better understand their stability during desolvation and in the gas phase. Although increasing net charge reduces quadruplex stability due to Coulombic repulsion, even highly charged quadruplex ions do not spontaneously dissociate. Notably, for quadruplexes with lower net
Anna Ploner   +2 more
wiley   +1 more source

Studies on the bound nucleotide of muscle fibrils [PDF]

open access: yes, 1963
The possibility was investigated that phosphorus uptake from ATP or uptake of ATP molecules by the muscle proteins occurs during contraction and relaxation of rabbit myofibrils.
Temperley, Eileen
core  

PharmVar GeneFocus: NAT2—Genetic Variation and Updated Nomenclature

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human N‐acetyltransferase 2 (NAT2) gene. NAT2 metabolizes several clinically used drugs including isoniazid, hydralazine, amifampridine, procainamide, and sulfonamides such as dapsone, and also some highly carcinogenic arylamines.
Georgia Papanikolaou   +14 more
wiley   +1 more source

Extracellular Adenine Nucleotides and Adenosine Modulate the Growth and Survival of THP-1 Leukemia Cells. [PDF]

open access: yesInt J Mol Sci, 2020
Puchałowicz K   +5 more
europepmc   +1 more source

Metabolic changes during cardiac regeneration in the axolotl

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background The axolotl is a prominent model organism of heart regeneration due to its ability to anatomically and functionally repair the heart after an injury that mimics human myocardial infarction. In humans, such an injury leads to permanent scarring. Cardiac regeneration has been linked to metabolism and the oxygenation state, but so far,
Anita Dittrich   +10 more
wiley   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li   +12 more
wiley   +1 more source

Computational modelling of myocardial metabolism in patients with advanced heart failure

open access: yesEuropean Journal of Heart Failure, EarlyView.
LV, left ventricular; LVAD, left ventricular assist device; LVEF, left ventricular ejection fraction. Abstract Aims Perturbations of myocardial metabolism and energy depletion are well‐established hallmarks of heart failure (HF), yet methods for their systematic assessment remain limited in humans.
Niklas Beyhoff   +17 more
wiley   +1 more source

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