CRISPR applications for Duchenne muscular dystrophy: From animal models to potential therapies
WIREs Mechanisms of Disease, Volume 15, Issue 1, January/February 2023., 2023 CRISPR‐Cas9 gene‐editing technology enables the rapid generation of animal models for Duchenne muscular dystrophy research and has potential to be developed as CRISPR therapy for the long lasting genetic correction of causal mutations. Abstract CRISPR gene‐editing technology creates precise and permanent modifications to DNA.
Yu C. J. Chey +4 more
wiley +1 more source
Mechanism of Activation of AMPK by Cordycepin [PDF]
, 2020 Atrih, Abdelmadjid +5 more
core +2 more sources
Changes in Adenine Nucleotides of Intact Chromatium D Produced by Illumination [PDF]
, 1967 Jane Gibson, Sigehiro Morita
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Chemistry – A European Journal, EarlyView.Toward new gold(III) anticancer agents. Herein, we report on an indazole‐based gold(III) carboxamide pincer complex exhibiting significant cytotoxicity, likely mediated through dual interactions with DNA. Mechanistic investigations suggest that the complex binds to the DNA and forms specific interactions with nucleotide bases.
Rufaro Razuwika +4 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.Using N1‐methyladenosine, a cancer biomarker as a target, a highly selective DNA aptamer was obtained with excellent selectivity and affinity, allowing the detection with a limit of detection of 1.9 µm. Abstract N1‐methyladenosine (m1A) level in urine increases in the presence of cancer and is associated with the tumor size and stage.
Esra Bağda, Efkan Bağda, Juewen Liu
wiley +1 more source
Characterization of the N6-etheno-bridge method to assess extracellular metabolism of adenine nucleotides: detection of a possible role for purine nucleoside phosphorylase in adenosine metabolism. [PDF]
Purinergic Signal, 2020 Jackson EK +4 more
europepmc +1 more source
Advances in Isotope Labeling for Solution Nucleic Acid NMR Spectroscopy
ChemPlusChem, Accepted Article.The availability of nucleic acid structural biology methods still lags behind that of proteins, as evidenced by the significantly smaller number of structures deposited in the PDB. The highly skewed ratio of nucleic acid structures, relative to their protein counterparts (~1:50), is inverted with respect to the cellular output of RNA and proteins in ...
Stefan Hilber +3 more
wiley +1 more source
Plasma Concentration of Irisin and Brain-Derived-Neurotrophic Factor and Their Association With the Level of Erythrocyte Adenine Nucleotides in Response to Long-Term Endurance Training at Rest and After a Single Bout of Exercise. [PDF]
Front Physiol, 2020 Rodziewicz E +4 more
europepmc +1 more source
Adenine nucleotide metabolism in diabetes [PDF]
Diabetologia, 1984 Ronald A. Hutton +3 more
openaire +3 more sources
HIGH PRESSURE EFFECTS ON ENDOGENOUS ADENINE NUCLEOTIDE LEVELS IN SEA URCHIN EGGS PRIOR TO FIRST CLEAVAGE [PDF]
, 1966 J. V. Landau
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