Results 171 to 180 of about 708,526 (362)

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, EarlyView.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li, Peixin Huang, Yue Qian, Anqi Lin, Jingjun He, Junyi Shen, Li Chen, Kai Miao, Jian Zhang   +8 more
wiley   +1 more source

Erratum: structural basis of AMPK regulation by adenine nucleotides and glycogen. [PDF]

Cell Res, 2015
Li X, Wang L, Zhou XE, Ke J, de Waal PW, Gu X, Eileen Tan MH, Wang D, Wu D, Eric Xu H, Melcher K.   +10 more
europepmc   +1 more source

Adenine and guanine nucleotide metabolism during platelet storage at 22 degrees C [PDF]

, 1990
CM Edenbrandt, S Murphy
openalex   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, EarlyView.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Adenine Nucleotides Attenuate Murine T Cell Activation Induced by Concanavalin A or T Cell Receptor Stimulation. [PDF]

Front Pharmacol, 2017
Shinohara Y, Tsukimoto M.
europepmc   +1 more source

ZapA uses a two‐pronged mechanism to facilitate Z ring formation in Escherichia coli

mLife, EarlyView.
Abstract The tubulin‐like protein FtsZ assembles into the Z ring that leads to the assembly and activation of the division machinery in most bacteria. ZapA, a widely conserved protein that interacts with FtsZ, plays a pivotal role in organizing FtsZ filaments into a coherent Z ring.
Yuanyuan Cui, Han Gong, Di Yan, Hao Li, Wenjie Yang, Ying Li, Xiangdong Chen, Joe Lutkenhaus, Sheng‐You Huang, Xinxing Yang, Shishen Du   +10 more
wiley   +1 more source

Plant defense strategies: The dual armor of disease resistance and tolerance

New Plant Protection, EarlyView.
Plants employ dual strategies against pathogens: Resistance limits invasion via immune responses, whereas tolerance mitigates damage to sustain growth—together enhancing survival under infections. Abstract Pathogen infections pose a significant threat to plant health, global food security, and ecosystems.
Zhijuan Tang, Shaosong Shi, Xinyu Du, Guoyong Xu   +3 more
wiley   +1 more source

Pleiotropic effects of the yeast Sal1 and Aac2 carriers on mitochondrial function via an activity distinct from adenine nucleotide transport

, 2008
Blanka Kucejová, Li Li, Xiaowen Wang, Sergio Giannattasio, Xin Jie Chen   +4 more
openalex   +1 more source

The Interaction between Cell Adhesion Molecule L1, Matrix Metalloproteinase 14, and Adenine Nucleotide Translocator at the Plasma Membrane Regulates L1-Mediated Neurite Outgrowth of Murine Cerebellar Neurons [PDF]

, 2012
Gabriele Loers, Tatjana Makhina, Ute Bork, Andrea Dörner, Melitta Schachner, Ralf Kleene   +5 more
openalex   +1 more source

RNA degradomics and proteomics reveal the mechanism of dsProsβ1‐mediated proteasome targeting in Psylliodes chrysocephala

Pest Management Science, EarlyView.
RNA degradomics revealed dsProsβ1‐derived siRNA‐mediated mRNA cleavage events, mainly at uracil‐guanine and adenine‐adenine pairs. Proteasome inhibition via dsProsβ1 increased mitochondrial and cytoskeletal proteins while reducing translation‐related and mRNA‐binding proteins.
Doga Cedden, Gözde Güney, Michael Rostás, Stefan Scholten   +3 more
wiley   +1 more source