Results 81 to 90 of about 117,271 (193)

Antagonism of Morphine Analgesia by Adenine, Adenosine, and Adenine Nucleotides

Experimental Biology and Medicine, 1973
SummaryAntagonism of the antinociceptive action of morphine in mice by prior parenteral administration of cAMP has been confirmed using two additional analgesic testing procedures, the hot-plate test and the stretching test. The analgesia-antagonistic property, however, is not specific for cAMP because it also occurred after pretreatment with compounds
D R, Gourley, S K, Beckner
openaire   +2 more sources

Cofactor Fingerprinting with STD NMR to Characterize Proteins of Unknown Function: Identification of a Rare cCMP Cofactor Preference [PDF]

, 2004
Proteomics efforts have created a need for better strategies to functionally categorize newly discovered proteins. To this end, we have employed saturation transfer difference NMR with pools of closely related cofactors, to determine cofactor preferences.
Sem, Daniel, Yao, Huili
core   +1 more source

Crystal structures of Ryanodine Receptor reveal dantrolene and azumolene interactions guiding inhibitor development

Nature Communications
The ryanodine receptor (RyR) is a critical drug target, yet dantrolene (DAN) remains the only FDA-approved inhibitor, limited by hepatotoxicity and unsuitable for chronic use.
Hadiatullah Hadiatullah, Lianyun Lin, Zhiyan Wang, Rajamanikandan Sundarraj, Qing Wang, Xinru Lai, Nagomi Kurebayashi, Takuya Kobayashi, Toshiko Yamazawa, Yu Seby Chen, Wenlan Wang, Hongxia Zhao, Yiqing Yin, Takashi Murayama, Filip Van Petegem, Zhiguang Yuchi   +15 more
doaj   +1 more source

Adenine nucleotide metabolism in diabetes [PDF]

Diabetologia, 1984
R A, Hutton, M A, Barradas, R, de Albarran, P, Dandona   +3 more
openaire   +2 more sources

Extracellular Adenine Nucleotides and Adenosine Modulate the Growth and Survival of THP-1 Leukemia Cells. [PDF]

Int J Mol Sci, 2020
Puchałowicz K, Tarnowski M, Tkacz M, Chlubek D, Kłos P, Dziedziejko V.   +5 more
europepmc   +1 more source

Flavin nucleotides in human lens: Regional distribution in Brunescent cataracts

Indian Journal of Ophthalmology, 1998
The biochemical mechanism(s) underlying brunescent cataracts remain unclear. Oxidative stress due to reactive oxygen species may have a role in the pigmentation process in eye lens.
Bhat K, Nayak Sujatha
doaj  

Synthesis and Preliminary Evaluation of an ASGPr-Targeted Polycationic β-Cyclodextrin Carrier for Nucleosides and Nucleotides

Pharmaceutics
Most antiviral and anticancer nucleosides are prodrugs that require stepwise phosphorylation to their triphosphate nucleotide form for biological activity.
Jang-Ha Ryu, Weizhong Zheng, Xiao-Hong Yang, Hassan Elsaidi, Jim Diakur, Leonard I. Wiebe   +5 more
doaj   +1 more source

Characterization of the N⁶-etheno-bridge method to assess extracellular metabolism of adenine nucleotides: detection of a possible role for purine nucleoside phosphorylase in adenosine metabolism. [PDF]

Purinergic Signal, 2020
Jackson EK, Gillespie DG, Cheng D, Mi Z, Menshikova EV.   +4 more
europepmc   +1 more source

Plasma Concentration of Irisin and Brain-Derived-Neurotrophic Factor and Their Association With the Level of Erythrocyte Adenine Nucleotides in Response to Long-Term Endurance Training at Rest and After a Single Bout of Exercise. [PDF]

Front Physiol, 2020
Rodziewicz E, Król-Zielińska M, Zieliński J, Kusy K, Ziemann E.   +4 more
europepmc   +1 more source

Encoding DNA sequences by integer chaos game representation

, 2017
DNA sequences are fundamental for encoding genetic information. The genetic information may not only be understood by symbolic sequences but also from the hidden signals inside the sequences.
Yin, Changchuan
core