Results 151 to 160 of about 6,350 (165)
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Adenine phosphoribosyltransferase deficiency and renal allograft dysfunction
American Journal of Kidney Diseases, 2001Adenine phosphoribosyltransferase (APRT) deficiency is a rarely diagnosed cause of renal allograft dysfunction. We report the case of a 42-year-old man who presented in 1996 with idiopathic renal failure. Native kidney biopsy showed extensive microcrystalline interstitial nephritis.
Alexander Kurbanov +5 more
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Adenine phosphoribosyltransferase deficiency in man
The American Journal of Medicine, 1973Abstract A second family is described in which there is a partial deficiency of erythrocyte adenine phosphoribosyltransferase (APRT). Eight affected members over three generations appear to be heterozygotes for a defect which is inherited in an autosomal manner.
Jean C. Meade +2 more
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The role of magnesium ion in the adenine phosphoribosyltransferase reaction
Canadian Journal of Biochemistry, 1970Low concentrations of magnesium ion stimulate, and high concentrations inhibit, the adenine phosphoribosyltransferase reaction. The stability constant of the Mg–pyrophosphoryl moiety of phosphoribosylpyrophosphate was assumed to be the same as that of Mg–adenosine triphosphate; the stability constant of the Mg–phosphoryl moiety of ...
Gadd Re, Henderson Jf
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The rate-limiting step in the adenine phosphoribosyltransferase reaction
Biochemical and Biophysical Research Communications, 1970Abstract Measurement of the effect of 2 H 2 O on the maximum velocity of adenine phosphoribosyltransferase suggests that removal of the proton from the 9-position of adenine is rate-limiting for this reaction. Studies of the effects of pH and of temperature on maximum velocity suggest that removal of this proton occurs by general base catalysis ...
J. Frank Henderson, R.E.A. Gadd
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Mutants of Saccharomyces cerevisiae deficient in adenine phosphoribosyltransferase
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1987Spontaneous and ethyl methanesulfate induced mutants of Saccharomyces cerevisiae, with partial and complete deficiency of adenine phosphoribosyltransferase (APRT, EC 2.4.2.7), were isolated by selection for resistance to 8-azaadenine. Matings between totally deficient mutants and tester strain resulted in diploid heterozygotes that were sensitive to ...
Milton W. Taylor +4 more
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Altered kinetic properties of a mutant adenine phosphoribosyltransferase
Metabolism, 1986Three siblings in a Japanese family experienced recurrent 2,8-dihydroxyadenine urolithiasis despite the presence of adenine phosphoribosyltransferase (APRT) activities in the hemolysates (19.9% to 28.2% of normal value). However, studies on viable T cells from these patients indicated that APRT was not functional in viable cells.
Ieo Akaoka +6 more
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The adenine phosphoribosyltransferase-encoding gene of Arabidopsis thaliana
Gene, 1994The apt gene, coding for adenine phosphoribosyltransferase (APRT), has been isolated from the plant Arabidopsis thaliana. Data from both Southern analysis and characterization of apt clones isolated from a genomic library is consistent with the occurrence of one apt within the A. thaliana genome.
Sunita K. Agarwal +3 more
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Purification and properties of rat liver adenine phosphoribosyltransferase
Biochimica et Biophysica Acta (BBA) - Enzymology, 1975The adenine phosphoribosyltransferase (AMP: pyrophosphate phosphoribosyltransferase, EC 2.4.2.7) of rat liver was purified to a specific activity of 1.1 mumol of AMP formed per min per mg. The enzyme activity is associated with an apparently homogenous protein as shown by isoelectrofocusing, acrylamide gel electrophoresis, and N-terminal amino acids ...
Leona G. Young +2 more
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Kinetic studies of inhibition of adenine phosphoribosyltransferase by guanylate
Biochimica et Biophysica Acta (BBA) - Enzymology, 1972Abstract Guanylate inhibits adenine phosphoribosyltransferase (AMP:pyrophosphate phosphoribosyltransferase, EC 2.4.2.7) and its binding to the enzyme is related to guanylate concentration in a hyperbolic manner. Double reciprocal plots of initial velocity are non-linear in the presence of guanylate, but linear in its absence.
Makoto Hori +3 more
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Diagnosis of Genotypes for Adenine Phosphoribosyltransferase (APRT) Deficiency
1989Adenine phosphoribosyltransferase (APRT) deficiency is a cause of urolithiasis and renal failure (1, 2). Due to the deficiency of APRT, adenine cannot be converted to AMP, and adenine thus accumulated in the body is catabolized to 2, 8-dihydroxyadenine via xanthine oxidase. Since 2, 8-dihydroxyadenine is a quite insoluble material, it makes crystals in
Masayuki Hakoda +5 more
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