Results 171 to 180 of about 87,339 (215)
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The FASEB Journal, 2021
Adenine phosphoribosyltransferase (APRT) is the key enzyme involved in purine salvage by the incorporation of adenine and phosphoribosyl pyrophosphate to provide adenylate nucleotides.
Guang-Huar Young +8 more
semanticscholar +1 more source
Adenine phosphoribosyltransferase (APRT) is the key enzyme involved in purine salvage by the incorporation of adenine and phosphoribosyl pyrophosphate to provide adenylate nucleotides.
Guang-Huar Young +8 more
semanticscholar +1 more source
Nephron, 2021
Adenine phosphoribosyltransferase (APRT) deficiency is a rare disorder caused by an autosomal recessive genetic disease leading to the deposition of 2,8-dihydroxyadenine (2,8-DHA) in the kidney.
Nicole Nourié +2 more
semanticscholar +1 more source
Adenine phosphoribosyltransferase (APRT) deficiency is a rare disorder caused by an autosomal recessive genetic disease leading to the deposition of 2,8-dihydroxyadenine (2,8-DHA) in the kidney.
Nicole Nourié +2 more
semanticscholar +1 more source
Hysteretic characteristic of adenine phosphoribosyltransferase
Biochemistry, 1975Preassay-incubation of the highly purified human erythrocyte adenine phosphoribosyltransferase (EC 2.4.2.7) (AMP pyrophosphorylase) with one of its substrates, 5-phosphoribosyl 1-pyrophosphate (PRibPP), changes the apparent V max value of the enzyme reaction.
L C, Yip, M E, Balis
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Adenine Phosphoribosyltransferase Deficiency in Iceland
Acta Medica Scandinavica, 1988Abstract. Two children and two adults of four unrelated families were on regular light microscopic examination found to exhibit identical, spherical urine crystals. Their characteristic appearance led to the diagnosis of 2,8‐dihydroxyadenine crystalluria by spectrophotometric or gas‐chromatographic/mass‐spectrometric analysis.
T, Laxdal, T A, Jónasson
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Adenine phosphoribosyltransferase deficiency in children
Pediatric Nephrology, 2012Adenine phosphoribosyltransferase (APRT) deficiency is a rare autosomal recessive disorder characterized by 2,8-dihydroxyadenine (2,8-DHA) crystalluria that can cause nephrolithiasis and chronic kidney disease. The aim of our study was to assess the clinical presentation, diagnosis, and outcome of APRT deficiency in a large pediatric cohort.
Jérôme, Harambat +4 more
openaire +2 more sources
[77] Adenine phosphoribosyltransferase
1978Publisher Summary This chapter describes the assay method of adenine phosphoribosyltransferase (APRT) enzyme. Human APRT catalyzes the magnesium-dependent transfer of the ribose-5-phosphate moiety of 5-phosphoribosyl-l-pyrophosphate (PP-ribose-P) to the 9 position of the purine base adenine to form adenosine-5'-monophosphate (AMP).
William J. Arnold, William N. Kelley
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Studies of the binding of adenine to adenine phosphoribosyltransferase
Canadian Journal of Biochemistry, 1970The groups on adenine phosphoribosyltransferase and on adenine which are involved in the binding of this substrate were investigated by comparing the inhibition constant of adenine with those obtained for analogues of adenine, by determining the effect of pH on the Michaelis constant of adenine, and by protection by adenine against enzyme inactivation
R E, Gadd, J F, Henderson
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A spectrophotometric assay for adenine phosphoribosyltransferase
Analytical Biochemistry, 1977Abstract The present paper describes a new spectrophotometric assay for adenine phosphoribosyltransferase activity which is highly reproducible, rapid, sensitive, and simpler than the isotopic assays for this enzyme. This assay is based on the quantitative measurement of the product AMP by a NADH-coupled enzyme method.
SALERNO, Costantino +1 more
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Adenine Phosphoribosyltransferase-Deficient Leishmania Donovani
1986Mutant promastigotes of Leishmania donovani deficient in adenine phosphoribosyltransferase (APRTase) have been isolated in medium containing 4-aminopyrazolopyrimidine. The generation of APRTase-deficient mutants occurred in two discrete steps. In the first step, clones were isolated with 50% of wildtype levels of APRTase activity.
K, Kaur, D M, Iovannisci, B, Ullman
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Characterization of an adenine phosphoribosyltransferase deficiency
Clinica Chimica Acta, 1988A case of adenine phosphoribosyltransferase deficiency in a 4.5-yr-old boy is described. A pedigree of the family, enzyme activities and kinetic data of the enzyme in the propositus and the carriers of the defect are presented. The amount of enzyme in the patient was about 2% of that in healthy subjects and correlated well with the amount of ...
P, Chiba, K, Zwiauer, M M, Müller
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