Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1 [PDF]
FEBS Letters, Volume 599, Issue 21, Page 3150-3162, November 2025.Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +2 more sources
Structural basis for substrate selectivity and nucleophilic substitution mechanisms in human adenine phosphoribosyltransferase catalyzed reaction. [PDF]
J Biol Chem, 2019 The reversible adenine phosphoribosyltransferase enzyme (APRT) is essential for purine homeostasis in prokaryotes and eukaryotes. In humans, APRT (hAPRT) is the only enzyme known to produce AMP in cells from dietary adenine. APRT can also process adenine
Ozeir M +17 more
europepmc +2 more sources
Glutamate Dehydrogenase from Thermus thermophilus Is Activated by AMP and Leucine as a Complex with Catalytically Inactive Adenine Phosphoribosyltransferase Homolog. [PDF]
J Bacteriol, 2019 GDH, which catalyzes the synthesis and degradation of glutamate using NAD(P)(H), is a widely distributed enzyme among all domains of life. Mammalian GDH is regulated allosterically by multiple metabolites, in which the antenna helix plays a key role to ...
Tomita T +6 more
europepmc +2 more sources
Adenine Phosphoribosyltransferase Deficiency [PDF]
Clinical Journal of the American Society of Nephrology, 2012 Summary Complete adenine phosphoribosyltransferase (APRT) deficiency is a rare inherited metabolic disorder that leads to the formation and hyperexcretion of 2,8-dihydroxyadenine (DHA) into urine. The low solubility of DHA results in precipitation of this compound and the formation of urinary crystals and stones.
Guillaume, Bollée +5 more
openaire +3 more sources
Adenine Phosphoribosyltransferase Deficiency: A Rare Cause of Recurrent Urolithiasis. [PDF]
J Endourol Case Rep, 2017 Background: Recurrent urolithiasis is troublesome for both patient and clinician, and in most cases, an underlying cause is not found. An important and underdiagnosed cause is adenine phosphoribosyltransferase (APRT) deficiency that gives rise to 2,8 ...
Jaffer A, Joyce A, Koenig P, Biyani CS.
europepmc +2 more sources
Febuxostat for the Prevention of Recurrent 2,8-dihydroxyadenine Nephropathy due to Adenine Phosphoribosyltransferase Deficiency Following Kidney Transplantation. [PDF]
Intern Med, 2017 Adenine phosphoribosyltransferase (APRT) deficiency is a rare autosomal recessive disorder that results in irreversible renal damage due to 2,8-dihydroxyadenine (DHA) nephropathy.
Nanmoku K +5 more
europepmc +2 more sources
Urinary 2,8-dihydroxyadenine excretion in patients with adenine phosphoribosyltransferase deficiency, carriers and healthy control subjects. [PDF]
Mol Genet Metab, 2019 Runolfsdottir HL +7 more
europepmc +2 more sources
Structural Insights into the Forward and Reverse Enzymatic Reactions in Human Adenine Phosphoribosyltransferase [PDF]
Cell Chemical Biology, 2018 J. Huyet +17 more
openalex +2 more sources