Results 41 to 50 of about 13,488 (222)

Metabolic engineering of the purine biosynthetic pathway in Corynebacterium glutamicum results in increased intracellular pool sizes of IMP and hypoxanthine [PDF]

, 2012
Background: Purine nucleotides exhibit various functions in cellular metabolism. Besides serving as building blocks for nucleic acid synthesis, they participate in signaling pathways and energy metabolism.
Barduhn, Tobias, Heinzle, Elmar, Peifer, Susanne, Schneider, Konstantin, Volmer, Dietrich A., Zimmet, Sarah   +5 more
core   +1 more source

Ability of metformin to deplete NAD+ contributes to cancer cell susceptibility to metformin cytotoxicity and is dependent on NAMPT expression

Frontiers in Oncology, 2023
BackgroundNicotinamide adenine dinucleotide (NAD+) is vital for not only energy metabolism but also signaling pathways. A major source of NAD+ depletion is the activation of poly (ADP-ribose) polymerase (PARP) in response to DNA damage.
Yongxian Zhuang, Allison B. Haugrud, Meg A. Schaefer, Meg A. Schaefer, Shanta M. Messerli, W. Keith Miskimins   +5 more
doaj   +1 more source

Crystal structure of hypoxanthine-guanine phosphoribosyltransferase [PDF]

, 2007
\ud \ud \ud \ud Background\ud \ud Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (EC 2.4.2.8) is a central enzyme in the purine recycling pathway.
Monzani, Paulo S, Trapani, Stefano , Thiemann, Otavio H, Oliva, Glaucius    +3 more
core   +1 more source

Thermophilic phosphoribosyltransferases Thermus thermophilus HB27 in nucleotide synthesis

Beilstein Journal of Organic Chemistry, 2018
Phosphoribosyltransferases are the tools that allow the synthesis of nucleotide analogues using multi-enzymatic cascades. The recombinant adenine phosphoribosyltransferase (TthAPRT) and hypoxanthine phosphoribosyltransferase (TthHPRT) from Thermus ...
Ilja V. Fateev, Ekaterina V. Sinitsina, Aiguzel U. Bikanasova, Maria A. Kostromina, Elena S. Tuzova, Larisa V. Esipova, Tatiana I. Muravyova, Alexei L. Kayushin, Irina D. Konstantinova, Roman S. Esipov   +9 more
doaj   +1 more source

Adenine phosphoribosyltransferase deficiency and 2, 8-dihydroxyadenine renal stones: A preventable cause of pediatric renal stones and kidney disease

Saudi Journal of Kidney Diseases and Transplantation, 2019
Adenine phosphoribosyltransferase deficiency is an inherited condition presenting from infancy to late adulthood. The common features are recurrent kidney and urinary tract stones and obstructive symptoms. The stones are characteristically radiolucent. 2,
Mital Dipakkkumar Parikh, Abhijit Konnur, Sishir Gang   +2 more
doaj   +1 more source

Pharmacology and clinical drug candidates in redox medicine [PDF]

, 2015
SIGNIFICANCE Oxidative stress is suggested to be a disease mechanism common to a wide range of disorders affecting human health. However, so far, the pharmacotherapeutic exploitation of this, for example, based on chemical scavenging of pro-oxidant ...
Casas, Ana I, Cuadrado, Antonio, Dao, V Thao-Vi, Di Lisa, Fabio, Ghezzi, Pietro, Jaquet, Vincent, Kaludercic, Nina, Maghzal, Ghassan J, Robledinos-Anton, Natalia, Schmidt, Harald H H W, Seredenina, Tamara, Stocker, Roland   +11 more
core   +3 more sources

Copper ions inhibit pentose phosphate pathway function in Staphylococcus aureus.

PLoS Pathogens, 2023
To gain a better insight of how Copper (Cu) ions toxify cells, metabolomic analyses were performed in S. aureus strains that lacks the described Cu ion detoxification systems (ΔcopBL ΔcopAZ; cop-).
Javiera Norambuena, Hassan Al-Tameemi, Hannah Bovermann, Jisun Kim, William N Beavers, Eric P Skaar, Dane Parker, Jeffrey M Boyd   +7 more
doaj   +1 more source

Trypanosoma brucei methylthioadenosine phosphorylase protects the parasite from the antitrypanosomal effect of deoxyadenosine [PDF]

, 2016
Trypanosoma brucei causes African sleeping sickness for which no vaccine exists and available treatments are of limited use due to their high toxicity or lack of efficacy. T.
de Koning, Harry P., Hofer, Anders, Pavlova, Anna, Ranjbarian, Farahnaz, Vodnala, Munender   +4 more
core   +1 more source

Recurrent 2,8-Dihydroxyadenine Crystalline Nephropathy in Renal Allograft

Annals of Internal Medicine: Clinical Cases
Adenine phosphoribosyltransferase deficiency is a rare cause of crystalline kidney disease. We present a case of end-stage kidney disease secondary to crystal deposition from adenine phosphoribosyltransferase deficiency with immediate recurrence of the ...
Farid Arman, Russell John Crew, Michael Barry Stokes, Jai Radhakrishnan   +3 more
doaj   +1 more source

Quinolinate Phosphoribosyltransferase Promotes Invasiveness of Breast Cancer Through Myosin Light Chain Phosphorylation

Frontiers in Endocrinology, 2021
Perturbed Nicotinamide adenine dinucleotide (NAD+) homeostasis is involved in cancer progression and metastasis. Quinolinate phosphoribosyltransferase (QPRT) is the rate-limiting enzyme in the kynurenine pathway participating in NAD+ generation.
Chien-Liang Liu, Chien-Liang Liu, Chien-Liang Liu, Shih-Ping Cheng, Shih-Ping Cheng, Shih-Ping Cheng, Ming-Jen Chen, Ming-Jen Chen, Ming-Jen Chen, Chi-Hsin Lin, Chi-Hsin Lin, Shan-Na Chen, Yi-Hue Kuo, Yuan-Ching Chang, Yuan-Ching Chang, Yuan-Ching Chang   +15 more
doaj   +1 more source