Results 61 to 70 of about 13,488 (222)

The Efficacy of Risk Factor Modification Compared to NAD+ Repletion in Diastolic Heart Failure

JACC: Basic to Translational Science
Summary: Heart failure (HF) with left ventricular diastolic dysfunction is a growing global concern. This study evaluated myocardial oxidized nicotinamide adenine dinucleotide (NAD+) levels in human systolic and diastolic HF and in a murine model of HF ...
Yen Chin Koay, PhD, Ren Ping Liu, BS, Bailey McIntosh, BS, Niv Vigder, BS, Serlin Lauren, BS, Angela Yu Bai, BS, Saki Tomita, BS, Desmond Li, PhD, Dylan Harney, PhD, Benjamin Hunter, PhD, Yunwei Zhang, PhD, Jean Yang, PhD, Paul Bannon, MD, PhD, Ashleigh Philp, PhD, Andrew Philp, PhD, David M. Kaye, MD, PhD, Mark Larance, PhD, Sean Lal, MD, PhD, John F. O’Sullivan, MD, PhD   +18 more
doaj   +1 more source

Mouse Model of Weak Depression Exhibiting Suppressed cAMP Signaling in the Amygdala, Lower Lipid Catabolism in Liver, and Correlated Gut Microbiota

Frontiers in Behavioral Neuroscience, 2022
To establish a mouse model of weak depression, we raised 6-week-old C57BL/6N mice in single (SH) or group housing (GH) conditions for 2 weeks. The SH group showed less social interaction with stranger mice, learning disability in behavioral tests, and ...
Kousuke Shimada, Masakatsu Nohara, Akihito Yasuoka, Akihito Yasuoka, Asuka Kamei, Fumika Shinozaki, Kaori Kondo, Kaori Kondo, Ryo Inoue, Takashi Kondo, Takashi Kondo, Keiko Abe, Keiko Abe   +12 more
doaj   +1 more source

Development and implementation of rapid metabolic engineering tools for chemical and fuel production in Geobacillus thermoglucosidasius NCIMB 11955 [PDF]

, 2017
Background The thermophile Geobacillus thermoglucosidasius has considerable attraction as a chassis for the production of chemicals and fuels. It utilises a wide range of sugars and oligosaccharides typical of those derived from lignocellulose and ...
AH Förster, AH Hussein, AJ Barczak, AJ Wolfe, B Reeve, CM Cooksley, D Mattanovich, DG Olson, E Denamur, EF Bosma, G Bitan-Banin, G Solar Del, G Unden, H Suzuki, I Sastalla, IE Maciag, J Bartosiak-Jentys, J Groom, J Liu, J Zhou, JL Fortman, Josef Altenbuchner, JT Heap, JT Heap, K Zhang, Katalin Kovács, Klaus Winzer, L Boe, L Deng, L González-Segura, L Sheng, Lili Sheng, M Ehsaan, M Matsumura, M Wellington, MP Taylor, MP Taylor, N Knipfer, Nigel Peter Minton, NP Minton, P Gay, P Harris, R Kiewiet, RE Cripps, RE Cripps, RW O’Brien, S Austin, S Bron, S Chang, SA Tripathi, SD Ehrlich, SR Maloy, ST Cartman, ST Cartman, T Sato, T Tanaka, T Yano, V Khetrapal, VI Bashkirov, Ying Zhang, YJ Choi, YK Ng   +61 more
core   +2 more sources

Thrombospondin‐4 is upregulated in abdominal aortic aneurysm: A vasoprotective response with potential therapeutic relevance

British Journal of Pharmacology, EarlyView.
TSP4 is upregulated in human and experimental AAA. TSP4 knockdown accelerated AAA formation and exacerbated both vascular inflammation and remodelling, emphasizing that TSP4 upregulation may represent a protective response against AAA. Our findings suggest that preserving TSP4 could be a useful strategy in the clinical management of AAA.
Laia Blanco‐Casoliva, Lidia Puertas‐Umbert, Judith Alonso, Rafael Almendra‐Pegueros, Saray Varona, Mercedes Camacho, Gemma Arderiu, Lluís Asmarats, Marta Alegret, Jose Martinez‐Gonzalez, Cristina Rodriguez   +10 more
wiley   +1 more source

Regulation of yak longissimus lumborum energy metabolism and tenderness by the AMPK/SIRT1 signaling pathways during postmortem storage

PLoS ONE, 2022
AMPK can activate nicotinamide phosphoribosyltransferase (NAMPT), increasing the ratio of oxidized nicotinamide adenine dinucleotide (NAD+)/reduced nicotinamide adenine dinucleotide (NADH) ratio, leading to the activation of the energy receptor SIRT1 ...
Yayuan Yang, Jieyuan Yang, Qunli Yu, Yongfang Gao, Ya Zheng, Ling Han, Xuezhi Ding   +6 more
doaj   +2 more sources

Nucleosided derived antibiotics to fight microbial drug resistance: New utilities for an established class of drugs? [PDF]

, 2016
Novel antibiotics are urgently needed to combat the rise of infections due to drug-resistant microorganisms. Numerous natural nucleosides and their synthetically modified analogues have been reported to have moderate to good antibiotic activity against ...
Ferrari, Valentina, Pertusati, Fabrizio, Serpi, Michaela   +2 more
core   +1 more source

The Mitochondrial NAD Transporter SLC25A51 in Adipocytes Regulates Adipose Tissue Mitochondrial Function and Systemic Metabolism During Aging

Aging Cell, Volume 25, Issue 5, May 2026.
We revealed the pathophysiological significance and therapeutic potential of adipocyte mitochondrial NAD transporter, namely solute carrier family 25 member 51 (SLC25A51), in age‐associated metabolic diseases, particularly adipose tissue mitochondrial function, obesity, and insulin resistance, by analyzing adipocyte‐specific Slc25a51 knockout (ASKO ...
Daiki Kojima, Keisuke Yaku, Shotaro Kosugi, Ryunosuke Mitsuno, Kenji Kaneko, Yoshinaga Kawano, Akihito Hishikawa, Seiya Mizuno, Manami Katoh, Akiko Satoh, Shinya Toyokuni, Tatsuhiko Azegami, Kenichiro Kinouchi, Shintaro Yamaguchi, Hiroshi Itoh, Takeshi Kanda, Toshimasa Yamauchi, Takashi Nakagawa, Kaori Hayashi, Jun Yoshino   +19 more
wiley   +1 more source

NAMPT and NAPRT, Key Enzymes in NAD Salvage Synthesis Pathway, Are of Negative Prognostic Value in Colorectal Cancer

Frontiers in Oncology, 2019
Nicotinamide adenine dinucleotide (NAD) is a profoundly important cofactor in redox reactions. Nicotinamide phosphoribosyltransferase (NAMPT) and nicotinate phosphoribosyltransferase (NAPRT) are key enzymes for NAD salvage biosynthesis pathway, which ...
Xiao-qin Li, Jing Lei, Lin-hong Mao, Qing-liang Wang, Feng Xu, Tao Ran, Zhi-hang Zhou, Song He   +7 more
doaj   +1 more source

Exercise training upregulates intracellular nicotinamide phosphoribosyltransferase expression in humans: a systematic review with meta-analysis

Frontiers in Public Health, 2023
ObjectiveAging is associated with decreased nicotinamide adenine dinucleotide (NAD) levels, which in turn cause dysfunctional mitochondria and indirectly affect a myriad of diseases. Intracellular nicotinamide phosphoribosyltransferase (iNAMPT) serves as
Xu Sun, Lide Su, Lide Su, Te Bu, Te Bu, Yang Zhang   +5 more
doaj   +1 more source

Exploring NAD(+) metabolism in host-pathogen interactions [PDF]

, 2016
Nicotinamide adenine dinucleotide (NAD+) is a vital molecule found in all living cells. NAD+ intracellular levels are dictated by its synthesis, using the de novo and/or salvage pathway, and through its catabolic use as co-enzyme or co-substrate.
Belinha, Ana, Gaifem, Joana, Mesquita, Inês Morais, Silvestre, Ricardo Jorge Leal   +3 more
core   +1 more source