Results 81 to 90 of about 13,488 (222)

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

HRS Degradation‐Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal‐Fetal Immune Homeostasis

Advanced Science, Volume 13, Issue 11, 23 February 2026.
This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei, Yuhan Lin, Xiu Liu, Xiaohong Zhu, Xiaowen Lu, Zhan Shi, Fan Jia, Shiqian Xu, Ling Fang, Lingling Jiang, Songying Zhang   +10 more
wiley   +1 more source

Adenine Phosphoribosyltransferase Is a Universal Counterselectable Marker for DNA-Free Genome Editing in Oomycetes

Molecular Plant-Microbe Interactions
CRISPR-Cas genome editing is a powerful tool for understanding the pathogenicity of oomycetes, a group that includes several destructive plant parasites.
Laurent Camborde, Chalisa Jaturapaktrarak, Jérôme Gouzy, Céline Lopez-Roques, Theerapong Krajaejun, Elodie Gaulin, Yacine Badis   +6 more
doaj   +1 more source

Supplementation of Nicotinic Acid with NAMPT Inhibitors Results in Loss of In Vivo Efficacy in NAPRT1-Deficient Tumor Models

Neoplasia: An International Journal for Oncology Research, 2013
Nicotinamide adenine dinucleotide (NAD) is a metabolite essential for cell survival and generated de novo from tryptophan or recycled from nicotinamide (NAM) through the nicotinamide phosphoribosyltransferase (NAMPT)-dependent salvage pathway ...
Thomas O'Brien, Jason Oeh, Yang Xiao, Xiaorong Liang, Alexander Vanderbilt, Ann Qin, Lulu Yang, Leslie B. Lee, Justin Ly, Ely Cosino, Jennifer A. LaCap, Annie Ogasawara, Simon Williams, Michelle Nannini, Bianca M. Liederer, Peter Jackson, Peter S. Dragovich, Deepak Sampath   +17 more
doaj   +1 more source

Metabolomics analysis of metabolic effects of nicotinamide phosphoribosyltransferase (NAMPT) inhibition on human cancer cells. [PDF]

PLoS ONE, 2014
Nicotinamide phosphoribosyltransferase (NAMPT) plays an important role in cellular bioenergetics. It is responsible for converting nicotinamide to nicotinamide adenine dinucleotide, an essential molecule in cellular metabolism. NAMPT has been extensively
Vladimir Tolstikov, Alexander Nikolayev, Sucai Dong, Genshi Zhao, Ming-Shang Kuo   +4 more
doaj   +1 more source

Proteome-wide analysis of Trypanosoma cruzi exponential and stationary growth phases reveals a subcellular compartment-specific regulation [PDF]

, 2018
Trypanosoma cruzi, the etiologic agent of Chagas disease, cycles through different life stages characterized by defined molecular traits associated with the proliferative or differentiation state. In particular, T. cruzi epimastigotes are the replicative
Avila, Carla Cristi, Barisón, María Julia, Costa-Martins, André Guillherme, de Oliveira, Gilberto Santos, Marinho, Claudio Romero Farias, Mule, Simon Ngao, Palmisano, Giuseppe, Rosa-Fernandes, Livia, Silber, Ariel Mariano, Teixeira, Marta Maria Geraldes, Viner, Rosa   +10 more
core   +3 more sources

Trypanosoma brucei adenine-phosphoribosyltransferases mediate adenine salvage and aminopurinol susceptibility but not adenine toxicity [PDF]

International Journal for Parasitology: Drugs and Drug Resistance, 2014
African trypanosomes, like all obligate parasitic protozoa, cannot synthesize purines de novo and import purines from their hosts to build nucleic acids. The purine salvage pathways of Trypanosoma brucei being redundant, none of the involved enzymes is likely to be essential.
Lüscher, Alexandra, Lamprea-Burgunder, Estelle, Graf, Fabrice E., De Koning, Harry, Mäser, Pascal   +4 more
openaire   +3 more sources

Oxygen Therapy for Intracranial Hemorrhage

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
Oxygen therapies confer neuroprotective effects on patients with intracranial hemorrhage through mechanisms such as anti‐inflammation, reduction of cerebral edema and neuronal death, and enhancement of aerobic metabolism. Clinical evidence suggests that oxygen therapy may improve neurological recovery and decrease mortality in patients with ...
Qiqi Shi, Song Han, Xiangyu Li, Jingwei Guan, Yanli Duan, Zhangyuan Liao, Zhiying Chen, Weili Li, Ran Meng, Ming Zou, Jiayue Ding   +10 more
wiley   +1 more source

"Your funeral... my trial": a review of the mechanisms leading to cancer cells death when targeting nicotinamide adenine dinucleotide [PDF]

, 2014
Le nicotinamide adénine dinucléotide (NAD) est un métabolite jouant un rôle crucial dans la vie cellulaire. Dans la mitochondrie, il est surtout utilisé comme co-enzyme d'oxydo-réduction afin de produire de l'énergie sous forme d'ATP (respiration ...
MORISOD, L.
core  

Lactobacillus paragasseri LG‐1 Alleviates Urticaria‐Like Symptoms in Mice via Modulation of Gut Microbiota, Hypoxanthine and Uric Acid

Microbial Biotechnology, Volume 19, Issue 2, February 2026.
Chronic Spontaneous Urticaria (CSU) is linked to gut dysbiosis and elevated serum uric acid/hypoxanthine. Lactobacillus paragasseri LG‐1 alleviates urticaria by degrading these metabolites, inhibiting TLR4‐NF‐κB inflammation, and remodelling gut microbiota.
Qiong Wang, Zhiming Hu, Yuqi Wang, ShuPing Guo, Xinglian Zhang, Yunqing Ren, Jinjun Li, Xiaoqiong Li, Hongzhou Cui   +8 more
wiley   +1 more source