Results 101 to 110 of about 13,488 (222)

High‐Efficiency Genome Editing of Chlorella sp. by CRISPR/Cas9

Plant Biotechnology Journal, Volume 24, Issue 4, Page 2123-2125, April 2026.
Xinyu Cui, Yi Xin, Yuan Xiao, Bixin Zhang, Qinhua Gan, Yandu Lu   +5 more
wiley   +1 more source

The Influence of Schwann Cell Metabolism and Dysfunction on Axon Maintenance

Glia, Volume 73, Issue 12, Page 2338-2352, December 2025.
Main Points Sensory neurons depend on Schwann cells for survival. Schwann cells provide energy for axons dunng rapid firing or after injury. Dysregulated metabolism in Schwann cells can lead to the production of neurotoxic and axon degeneration. ABSTRACT Schwann cells are the glial cells in the peripheral nervous system responsible for the production ...
Rose Follis, Vishwanath V. Prabhu, Bruce D. Carter   +2 more
wiley   +1 more source

The HSV-1 Latency-Associated Transcript Functions to Repress Latent Phase Lytic Gene Expression and Suppress Virus Reactivation from Latently Infected Neurons [PDF]

, 2016
open access articleHerpes simplex virus 1 (HSV-1) establishes life-long latent infection within sensory neurons, during which viral lytic gene expression is silenced.
Coleman, Heather M., Connor, Viv, Efstathiou, Stacey, Hann, William, Harman, Laura E.R., Nicoll, Michael P., Proenca, Joao T., Shivkumar, Maitreyi   +7 more
core   +3 more sources

Partial Adenine Phosphoribosyltransferase Deficiency Detected by Ureterolithiasis.

Internal Medicine, 1998
A 30-year-old woman was admitted to our hospital because of recurrent ureterolithiasis. She was suspected of having adenine phosphoribosyltransferase (APRT) deficiency based on the presence of 2,8-dihydroxyadenine (DHA) crystals in her urinary sediment, infrared spectrophotometric analysis of the excreted stone, and then the definitive diagnosis by ...
K, Inagaki, A, Muraoka, I, Suehiro, M, Fujii, H, Ueno, T, Hosooka, K, Kida, K, Murakami   +7 more
openaire   +3 more sources

De novo NAD+ synthesis is ineffective for NAD+ supply in axenically cultured Caenorhabditis elegans

Communications Biology
To secure an adequate nicotinamide adenine dinucleotide (NAD+) supply for survival, organisms typically rely on two complementary mechanisms: the de novo synthesis pathway and the salvage pathway.
Shihao Zhu, Runshuai Zhang, Luxia Yao, Zhirong Lin, Yanjie Li, Siyuan Li, Lianfeng Wu   +6 more
doaj   +1 more source

dGTP starvation in Escherichia coli provides new insights into the thymineless-death phenomenon.

PLoS Genetics, 2014
Starvation of cells for the DNA building block dTTP is strikingly lethal (thymineless death, TLD), and this effect is observed in all organisms. The phenomenon, discovered some 60 years ago, is widely used to kill cells in anticancer therapies, but many ...
Mark Itsko, Roel M Schaaper
doaj   +1 more source

Urinary 2,8-dihydroxyadenine crystals in a patient with adenine phosphoribosyltransferase deficiency. [PDF]

QJM, 2023
Horino T, Ishihara M, Fujieda M.
europepmc   +1 more source

NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion [PDF]

, 2016
Overexpression of the NAD(+) biosynthetic enzyme NMNAT1 leads to preservation of injured axons. While increased NAD(+) or decreased NMN levels are thought to be critical to this process, the mechanism(s) of this axon protection remain obscure.
Araki, Babetto, Coleman, Conforti, Di Stefano, Elliott, Gerdts, Gerdts, Gerdts, Gerdts, Gilley, Gilley, Hara, Hikosaka, Lois, Mack, Osterloh, Revollo, Sasaki, Sasaki, Sasaki, Sasaki, Szretter, Wang, Wang   +24 more
core   +3 more sources

Mechanisms of the NAD+ salvage pathway in enhancing skeletal muscle function

Frontiers in Cell and Developmental Biology
Nicotinamide adenine dinucleotide (NAD+) is crucial for cellular energy production, serving as a coenzyme in oxidation-reduction reactions. It also supports enzymes involved in processes such as DNA repair, aging, and immune responses.
Mengzhu Su, Mengzhu Su, Fanghui Qiu, Yansong Li, Tongtong Che, Ningning Li, Shuangshuang Zhang, Shuangshuang Zhang   +7 more
doaj   +1 more source

NAMPT overexpression alleviates alcohol-induced hepatic steatosis in mice.

PLoS ONE, 2019
Nicotinamide phosphoribosyltransferase (NAMPT) is a rate-limiting enzyme in mammalian nicotinamide adenine dinucleotide (NAD)+ biosynthesis. Through its NAD+-biosynthetic activity, NAMPT influences the activity of NAD+-dependent enzymes, such as sirtuins.
Xiwen Xiong, Jiahui Yu, Rui Fan, Cuicui Zhang, Lin Xu, Xupeng Sun, Yanmei Huang, Qingzhi Wang, Hai-Bin Ruan, Xinlai Qian   +9 more
doaj   +1 more source