Results 111 to 120 of about 13,488 (222)

P7C3 Neuroprotective Chemicals Block Axonal Degeneration and Preserve Function after Traumatic Brain Injury

Cell Reports, 2014
The P7C3 class of neuroprotective aminopropyl carbazoles has been shown to block neuronal cell death in models of neurodegeneration. We now show that P7C3 molecules additionally preserve axonal integrity after injury, before neuronal cell death occurs ...
Terry C. Yin, Jeremiah K. Britt, Héctor De Jesús-Cortés, Yuan Lu, Rachel M. Genova, Michael Z. Khan, Jaymie R. Voorhees, Jianqiang Shao, Aaron C. Katzman, Paula J. Huntington, Cassie Wassink, Latisha McDaniel, Elizabeth A. Newell, Laura M. Dutca, Jacinth Naidoo, Huxing Cui, Alexander G. Bassuk, Matthew M. Harper, Steven L. McKnight, Joseph M. Ready, Andrew A. Pieper   +20 more
doaj   +1 more source

Methylthioadenosine [PDF]

, 2004
5'-Methylthioadenosine (MTA) is a naturally occurring sulfur-containing nucleoside present in all mammalian tissues. MTA is produced from S-adenosylmethionine mainly through the polyamine biosynthetic pathway, where it behaves as a powerful inhibitory ...
Avila, M.A. (Matías Antonio), Corrales, F.J. (Fernando José), Lu, S.C. (Shelly C.), Mato, J.M. (José María), Ruiz Garcia-Trevijano, E. (Elena)   +4 more
core   +1 more source

A case of 2,8-DHA crystalline nephropathy caused by adenine phosphoribosyltransferase deficiency: diagnosis and treatment. [PDF]

CEN Case Rep, 2023
Kunou M, Yamaguchi M, Takahashi H, Kimura Y, Watanabe N, Ito M, Sugiyama H, Iwagaitsu S, Nobata H, Kinashi H, Katsuno T, Banno S, Ito Y, Ishimoto T.   +13 more
europepmc   +1 more source

Emerging therapeutic roles for NAD+ metabolism in mitochondrial and age-related disorders [PDF]

, 2016
Nicotinamide adenine dinucleotide (NAD(+)) is a central metabolic cofactor in eukaryotic cells that plays a critical role in regulating cellular metabolism and energy homeostasis. NAD(+) in its reduced form (i.e.
Sarika Srivastava
core   +1 more source

Genetic ablation of purine salvage in Cryptosporidium parvum reveals nucleotide uptake from the host cell [PDF]

, 2019
The apicomplexan parasite Cryptosporidium is a leading global cause of severe diarrheal disease and an important contributor to early-childhood mortality. Waterborne outbreaks occur frequently, even in countries with advanced water treatment capabilities,
Cuny, Gregory D., Gibson, Alexis, Hedstrom, Lizbeth, Herbert, Gillian T., Pawlowic, Mattie, Sateriale, Adam, Somepalli, Mastanbabu, Striepen, Boris   +7 more
core   +2 more sources

Effect of Caffeine on the Expression Pattern of Water-Soluble Proteins in Rice () Seedlings

Natural Product Communications, 2015
It has been suggested that caffeine acts as an allelochemical which influences the germination and growth of plants. The effect of caffeine on the expression profiles of proteins was investigated in shoot-root axes of rice (Oryza sativa) seedlings.
Wei-Wei Deng, Hamako Sasamoto, Hiroshi Ashihara   +2 more
doaj   +1 more source

CodY, a pleiotropic regulator, influences multicellular behaviour and efficient production of virulence factors in Bacillus cereus [PDF]

, 2012
In response to nutrient limitation in the environment, the global transcriptional regulator CodY modulates various pathways in low G+C Gram-positive bacteria.
Basset, Coraline, Granum, Per Einar, Kovacs, Akos T., Kuipers, Oscar P., Lindback, Toril, Lindbäck, Toril, Mols, Maarten   +6 more
core   +3 more sources

Allele frequency of variants reported to cause adenine phosphoribosyltransferase deficiency. [PDF]

Eur J Hum Genet, 2021
Runolfsdottir HL, Sayer JA, Indridason OS, Edvardsson VO, Jensson BO, Arnadottir GA, Gudjonsson SA, Fridriksdottir R, Katrinardottir H, Gudbjartsson D, Thorsteinsdottir U, Sulem P, Stefansson K, Palsson R.   +13 more
europepmc   +1 more source

Characterization of adenine phosphoribosyltransferase (APRT) activity in Trypanosoma brucei brucei: Only one of the two isoforms is kinetically active. [PDF]

PLoS Negl Trop Dis, 2022
Glockzin K, Meek TD, Katzfuss A.
europepmc   +1 more source

Metabolic and neurobehavioral disturbances induced by purine recycling deficiency in Drosophila

eLife
Adenine phosphoribosyltransferase (APRT) and hypoxanthine-guanine phosphoribosyltransferase (HGPRT) are two structurally related enzymes involved in purine recycling in humans.
Céline Petitgas, Laurent Seugnet, Amina Dulac, Giorgio Matassi, Ali Mteyrek, Rebecca Fima, Marion Strehaiano, Joana Dagorret, Baya Chérif-Zahar, Sandrine Marie, Irène Ceballos-Picot, Serge Birman   +11 more
doaj   +1 more source