Results 31 to 40 of about 9,435,635 (153)

Familial and genetic overlap between Sjögren’s disease and other autoimmune diseases

Frontiers in Immunology
PurposeTo evaluate familial clustering of Sjögren’s disease (SjD) with other autoimmune diseases and to characterize shared genetic architecture using an integrative genomic approach.MethodsMeta-analysis identified studies assessing autoimmune disease ...
Hitomi Ono-Minagi, Hitomi Ono-Minagi, Takuma Ohnishi, Natalie Atyeo, Kentaro Okuno, Peter D. Burbelo, John A. Chiorini   +6 more
doaj   +1 more source

Retrograde capabilities of adeno-associated virus vectors in the central nervous system [PDF]

, 2021
Adeno-associated virus (AAV) vectors delivered at the axonal terminals can be retrogradely transported toward neuronal cell bodies throughout the axons.
Surdyka, M.M., Figiel, M., Maciej Figiel, Magdalena Surdyka   +3 more
core   +1 more source

Virus Binding and Internalization Assay for Adeno-associated Virus

Bio-Protocol, 2017
The binding and internalization of adeno-associated virus (AAV) is an important determinant of viral infectivity and tropism. The ability to dissect these two tightly connected cellular processes would allow better understanding and provide insight on ...
Garrett Berry, Victor Tse
doaj   +1 more source

The effects of anti-sense interleukin-5 gene transferred by recombinant adeno-associated virus in allergic rats [PDF]

, 2008
The accumulation and infiltration of eosinophils in airways is one of the most important characteristics of asthma, and is mediated partly by secretion of IL-5 from Th2 lymphocytes.
Weining Xiong, Qingfeng Song, Yongjian Xu, Xiansheng Liu, Daxiong Zeng, Yong Cao, Chao Cao   +6 more
core  

Adeno-associated virus: from defective virus to effective vector

Virology Journal, 2005
The initial discovery of adeno-associated virus (AAV) mixed with adenovirus particles was not a fortuitous one but rather an expression of AAV biology.
Gonçalves Manuel AFV
doaj   +1 more source

Adeno-Associated Virus (AAV) Versus Immune Response

Viruses, 2019
Decades ago, Friedmann and Roblin postulated several barriers to gene therapy, including tissue targeting, delivery across the blood⁻brain barrier (BBB), and host immune responses. These issues remain pertinent till today.
Joseph Rabinowitz, Ying Kai Chan, Richard Jude Samulski   +2 more
doaj   +1 more source

Silencing of UTX Mitigates Aging-Associated Cardiac Fibrosis via Blocking Cardiac Fibro blaststo-Myofibroblasts Trans-Differentiation

Anatolian Journal of Cardiology, 2023
Background: Cardiac fibrosis increases with age. Fibroblast activation plays an essential role in cardiac fibrosis. Histone modifications are involved in various chromatin-dependent processes.
Chao Li, Tiantian Lin, Delin Li, Daoyuan Si, Huan Sun, Sibao Yang, Zhongfan Zhang, Qian Zhang, Kaiyao Shi   +8 more
doaj   +1 more source

Extracellular vesicles enhance pulmonary transduction of stably associated adeno‐associated virus following intratracheal administration

Journal of Extracellular Vesicles, 2023
Adeno‐associated virus (AAV) vector has shown multiple clinical breakthroughs, but its clinical implementation in inhaled gene therapy remains elusive due to difficulty in transducing lung airway cells.
Gijung Kwak, Olesia Gololobova, Neeraj Sharma, Colin Caine, Marina Mazur, Kathleen Mulka, Natalie E. West, George M. Solomon, Garry R. Cutting, Kenneth W. Witwer, Steven M. Rowe, Michael Paulaitis, George Aslanidi, Jung Soo Suk   +13 more
doaj   +1 more source

Sex significantly influences transduction of murine liver by recombinant adeno-associated viral vectors through an androgen-dependent pathway. [PDF]

, 2003
A systematic evaluation of the influence of sex on transduction by recombinant adeno-associated viral vector (rAAV) indicated that transgene expression after liver-targeted delivery of vector particles was between 5- to 13-fold higher in male mice ...
Spence, Y, Ng, CYC, Nathwani, AC, Davidoff, AM, Zhou, J   +4 more
core  

Mutation-independent treatment of autosomal dominant Retinitis Pigmentosa (adRP) [PDF]

, 2010
Viral-mediated gene therapy holds great promise for the treatment of severe inherited retinal diseases, such as Retintitis Pigmentosa (RP), which is caused by mutations in genes preferentially expressed in photoreceptor cells. The availability of vectors
Mussolino, Claudio
core   +1 more source