Results 11 to 20 of about 110,488 (256)

Adeno‐associated virus (AAV)-based gene therapy for glioblastoma

Cancer Cell International, 2021
Glioblastoma (GBM) is the most common and malignant Grade IV primary craniocerebral tumor caused by glial cell carcinogenesis with an extremely poor median survival of 12–18 months.
Xin Xu, Wenli Chen, Wenjun Zhu, Jing Chen, Bin Ma, Jianxia Ding, Zaichuan Wang, Yifei Li, Yeming Wang, Xiaochun Zhang   +9 more
doaj   +1 more source

Transduction of Salivary Gland Acinar Cells with a Novel AAV Vector 44.9

Molecular Therapy: Methods & Clinical Development, 2020
The loss of salivary gland function caused by radiation therapy of the head and neck or autoimmune disease such as Sjögren’s syndrome is a serious condition that affects a patient’s quality of life. Due to the combined exocrine and endocrine functions of
Giovanni Di Pasquale, Paola Perez Riveros, Muhibullah Tora, Tayyab Sheikh, Aran Son, Leyla Teos, Brigitte Grewe, William D. Swaim, Sandra Afione, Changyu Zheng, Shyh-Ing Jang, Akiko Shitara, Ilias Alevizos, Roberto Weigert, John A. Chiorini   +14 more
doaj   +1 more source

Clinical and laboratory evaluation of sicca complaints: distinctive aspects of primary, secondary and non-Sjogren syndrome

Advances in Rheumatology, 2022
Background Sjögren Syndrome (SS) is a systemic autoimmune disease with a wide spectrum of manifestations that can lead to misdiagnosis. This study describes and compares demographic, clinical, serological, and histopathological data from subjects with SS
Fabíola Reis de Oliveira, Ana Carolina F. Motta, Carolina Maria Módulo, Denny Marcos Garcia, John A. Chiorini, Paulo Louzada-Junior, Eduardo Melani Rocha   +6 more
doaj   +1 more source

The landscape of viral associations in human cancers [PDF]

, 2020
Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, for which whole-genome and—for a subset—whole-transcriptome sequencing data from 2,658 cancers across 38 tumor types was aggregated, we systematically investigated potential ...
Alawi, Malik, Borozan, Ivan, Brewer, Daniel S, Cooper, Colin S, Desai, Nikita, Eils, Roland, Ferretti, Vincent, Grundhoff, Adam, Iskar, Murat, Lichter, Peter, Moch, Holger, PCAWG Consortium, PCAWG Pathogens, Sültmann, Holger, Zapatka, Marc   +14 more
core   +3 more sources

Progress in the use of adeno-associated viral vectors for gene therapy [PDF]

, 2004
The development of safe and efficient gene transfer vectors is crucial for the success of gene therapy trials. A viral vector system promising to meet these requirements is based on the apathogenic adeno-associated virus (AAV-2), a member of the ...
Braun-Falco, M., Buning, H., Hallek, M.
core   +1 more source

Sustained high-level expression of human factor IX (hFIX) after liver-targeted delivery of recombinant adeno-associated virus encoding the hFIX gene in rhesus macaques [PDF]

, 2002
The feasibility, safety, and efficacy of liver-directed gene transfer was evaluated in 5 male macaques (aged 2.5 to 6.5 years) by using a recombinant adeno-associated viral (rAAV) vector (rAAV-2 CAGG-hFIX) that had previously mediated persistent ...
Davidoff, AM, Hanawa, H, Hoffer, FA, Hu, Y, Lozier, JN, Mandrell, TD, Nathwani, AC, Ng, CYC, Nienhuis, AW, Nikanorov, A, Slaughter, C, Vanin, EF, Zhou, J   +12 more
core   +1 more source

Factors influencing in vivo transduction by recombinant adeno-associated viral vectors expressing the human factor IX cDNA. [PDF]

, 2001
Long-term expression of coagulation factor IX (FIX) has been observed in murine and canine models following administration of recombinant adeno-associated viral (rAAV) vectors into either the portal vein or muscle. These studies were designed to evaluate
Davidoff, A, Hanawa, H, Nathwani, AC, Nienhuis, AW, Vanin, EF, Zhou, JF   +5 more
core   +1 more source

Muscle regeneration affects Adeno Associated Virus 1 mediated transgene transcription

Scientific Reports, 2022
Duchenne muscular dystrophy is a severe neuromuscular disease causing a progressive muscle wasting due to mutations in the DMD gene that lead to the absence of dystrophin protein.
Amédée Mollard, Cécile Peccate, Anne Forand, Julie Chassagne, Laura Julien, Pierre Meunier, Zoheir Guesmia, Thibaut Marais, Marc Bitoun, France Piétri-Rouxel, Sofia Benkhelifa-Ziyyat, Stéphanie Lorain   +11 more
doaj   +1 more source

Sex significantly influences transduction of murine liver by recombinant adeno-associated viral vectors through an androgen-dependent pathway. [PDF]

, 2003
A systematic evaluation of the influence of sex on transduction by recombinant adeno-associated viral vector (rAAV) indicated that transgene expression after liver-targeted delivery of vector particles was between 5- to 13-fold higher in male mice ...
Davidoff, AM, Nathwani, AC, Ng, CYC, Spence, Y, Zhou, J   +4 more
core   +1 more source

Fluorescence Microscopy in Adeno-Associated Virus Research

Viruses, 2023
Research on adeno-associated virus (AAV) and its recombinant vectors as well as on fluorescence microscopy imaging is rapidly progressing driven by clinical applications and new technologies, respectively.
Susanne K. Golm, Wolfgang Hübner, Kristian M. Müller   +2 more
doaj   +1 more source