Results 1 to 10 of about 3,915 (69)

Sclerosing Sialadenitis Is Associated With Salivary Gland Hypofunction and a Unique Gene Expression Profile in Sjögren’s Syndrome

Frontiers in Immunology, 2021
PurposeTo develop a novel method to quantify the amount of fibrosis in the salivary gland and to investigate the relationship between fibrosis and specific symptoms associated with Sjögren’s syndrome (SS) using this method.Materials and MethodsParaffin ...
Hongen Yin, Thomas J. F. Pranzatelli, Benjamin N. French, Nan Zhang, Blake M. Warner, John A. Chiorini, NIDCD/NIDCR Genomics and Computational Biology Core   +6 more
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Advancing Luciferase-Based Antibody Immunoassays to Next-Generation Mix and Read Testing

Biosensors, 2023
Antibody measurements play a central role in the diagnosis of many autoimmune and infectious diseases. One antibody detection technology, Luciferase Immunoprecipitation Systems (LIPS), utilizes genetically encoded recombinant luciferase antigen fusion ...
Peter D. Burbelo, Youngmi Ji, Michael J. Iadarola   +2 more
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Correction of LAMP3-associated salivary gland hypofunction by aquaporin gene therapy

Scientific Reports, 2022
Sjögren’s disease (SjD) is a chronic autoimmune sialadenitis resulting in salivary gland hypofunction with dry mouth symptom. Previous studies showed that lysosome-associated membrane protein 3 (LAMP3) overexpression is involved in the development of ...
Hiroyuki Nakamura, Tsutomu Tanaka, Changyu Zheng, Sandra A. Afione, Blake M. Warner, Masayuki Noguchi, Tatsuya Atsumi, John A. Chiorini   +7 more
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Sarcopenia and coexistent risk factors detected using the ‘Yubi-wakka’ (finger-ring) test in adults aged over 65 years in the public annual health check-up in Tama City, Tokyo: a cross-sectional study

BMJ Open, 2022
Objectives To examine the positive rate of sarcopenia using the ‘Yubi-wakka’ (finger-ring) test and associated risk factors among adults aged 65 years and older.Design Cross-sectional study.Setting We used the Yubi-wakka test, which has been developed ...
Hiroyuki Nakamura, Hitomi Fujii, Eitaro Kodani, Tomohiro Kaneko, Hajime Sasabe, Yutaka Tamura   +5 more
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Adeno-associated virus receptor complexes and implications for adeno-associated virus immune neutralization

Frontiers in Microbiology, 2023
Adeno-associated viruses (AAV) are among the foremost vectors for in vivo gene therapy. A number of monoclonal antibodies against several serotypes of AAV have previously been prepared.
Edward E. Large, Michael S. Chapman
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LAMP3 transfer via extracellular particles induces apoptosis in Sjögren’s disease

Scientific Reports, 2023
Sjögren’s disease (SjD) is an autoimmune disease that affects exocrine tissues and is characterized by increased apoptosis in salivary and lacrimal glands.
Tsutomu Tanaka, Hiroyuki Nakamura, Duy T. Tran, Blake M. Warner, Yan Wang, Tatsuya Atsumi, Masayuki Noguchi, John A. Chiorini   +7 more
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Intravenous immunoglobulin prevents peripheral liver transduction of intrathecally delivered AAV vectors

Molecular Therapy: Methods & Clinical Development, 2022
Gene therapy using neurotropic adeno-associated virus vectors represents an emerging solution for genetic disorders affecting the central nervous system. The first approved central nervous system-targeting adeno-associated virus gene therapy, Zolgensma®,
Makoto Horiuchi, Christian J. Hinderer, Jenny A. Greig, Cecilia Dyer, Elizabeth L. Buza, Peter Bell, Jessica A. Chichester, Peter M. Hayashi, Hanying Yan, Tamara Goode, James M. Wilson   +10 more
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Adeno‐associated virus (AAV)-based gene therapy for glioblastoma

Cancer Cell International, 2021
Glioblastoma (GBM) is the most common and malignant Grade IV primary craniocerebral tumor caused by glial cell carcinogenesis with an extremely poor median survival of 12–18 months.
Xin Xu, Wenli Chen, Wenjun Zhu, Jing Chen, Bin Ma, Jianxia Ding, Zaichuan Wang, Yifei Li, Yeming Wang, Xiaochun Zhang   +9 more
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Transduction of Salivary Gland Acinar Cells with a Novel AAV Vector 44.9

Molecular Therapy: Methods & Clinical Development, 2020
The loss of salivary gland function caused by radiation therapy of the head and neck or autoimmune disease such as Sjögren’s syndrome is a serious condition that affects a patient’s quality of life. Due to the combined exocrine and endocrine functions of
Giovanni Di Pasquale, Paola Perez Riveros, Muhibullah Tora, Tayyab Sheikh, Aran Son, Leyla Teos, Brigitte Grewe, William D. Swaim, Sandra Afione, Changyu Zheng, Shyh-Ing Jang, Akiko Shitara, Ilias Alevizos, Roberto Weigert, John A. Chiorini   +14 more
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Clinical and laboratory evaluation of sicca complaints: distinctive aspects of primary, secondary and non-Sjogren syndrome

Advances in Rheumatology, 2022
Background Sjögren Syndrome (SS) is a systemic autoimmune disease with a wide spectrum of manifestations that can lead to misdiagnosis. This study describes and compares demographic, clinical, serological, and histopathological data from subjects with SS
Fabíola Reis de Oliveira, Ana Carolina F. Motta, Carolina Maria Módulo, Denny Marcos Garcia, John A. Chiorini, Paulo Louzada-Junior, Eduardo Melani Rocha   +6 more
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