Results 71 to 80 of about 9,435,635 (153)

Advanced biomanufacturing and evaluation of adeno-associated virus

Journal of Biological Engineering
Recombinant adeno-associated virus (rAAV) has been developed as a safe and effective gene delivery vehicle to treat rare genetic diseases. This study aimed to establish a novel biomanufacturing process to achieve high production and purification of ...
Kai Chen, Seulhee Kim, Siying Yang, Tanvi Varadkar, Zhuoxin Zora Zhou, Jiashuai Zhang, Lufang Zhou, Xiaoguang Margaret Liu   +7 more
doaj   +1 more source

Adeno-Associated Virus Antibody Profiles in Newborns, Children, and Adolescents

, 2011
Neutralizing antibodies (NAb) to an adeno-associated virus (AAV) vector due to previous natural infection with wild-type AAV can significantly limit gene transfer.
David Jones, Roberto Calcedo, Jianping He, Robert McCarter, Mark L. Batshaw, James M. Wilson, Hiroki Morizono, Lili Wang   +7 more
core   +1 more source

A recombinant avian adeno-associated virus as a vector for infectious bursal disease vaccination.

Revista Científica, 2010
Infectious bursal disease is a worldwide distributed immunosuppressive disease of young chickens that need to be controlled by vaccination; it represents one of the main concerns for the poultry industry.
Francisco Perozo, Pedro Villegas, Carlos Estévez, Ivan Alvarado, Linda Purvis   +4 more
doaj  

VEGFC/VEGFR3 Signaling‐Dependent Lymphatic Remodeling Modulates Cardiac Response to Pressure Overload

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Cardiac lymphangiogenesis has been proposed as a potential therapeutic target to prevent the development of heart failure. However, the efficiency of systemically delivered VEGFC (vascular endothelial growth factor C) protein in inducing ...
Lina Su, Yuxia Cui, Manyan Wu, Shiran Yu, Chunying Zhang, Ziqi Song, Shuolei Li, Hang Lin, Zheng Lian, Chongyou Lee, Chuanfen Liu, Sufang Li, Junxian Song, Hong Chen   +13 more
doaj   +1 more source

Adeno-associated virus-mediated gene therapy for genetic epilepsy: prospects and challenges

中国当代儿科杂志
With the development and launch of anti-seizure medications, some genetic epilepsies have precision treatments; however, many patients remain drug-resistant, which severely affects quality of life and overall health. Advances in gene therapy have changed
SUN Bo, WANG Xiao-Le, PENG Jing
doaj   +1 more source

Adeno-Associated Virus Engineering and Load Strategy for Tropism Modification, Immune Evasion and Enhanced Transgene Expression [PDF]

Xun Zhou,1,2,* Jingzhou Liu,2,* Shuang Xiao,2,3,* Xiaoqing Liang,1,2 Yi Li,2 Fengzhen Mo,3 Xin Xin,2 Yang Yang,2 Chunsheng Gao1,2 1School of Pharmacy, Henan University, Kaifeng, People’s Republic of China; 2State Key Laboratory of Toxicology ...
Liu J, Li Y, Yang Y, Liang X, Mo F, Xin X, Zhou X, Xiao S, Gao C   +8 more
core  

Reduced rAAV interference enhances rcAAV detection sensitivity

Molecular Therapy: Methods & Clinical Development
Replication-competent adeno-associated virus (rcAAV) content is a crucial contaminant in the process of recombinant adeno-associated virus (rAAV) production in gene therapy products, from preclinical to clinical stages.
Ming Yang, Sana Shaheen, Keying Yang, Xuxia Gao, Kaiwen Wu, Xiangying Zhu, Qian Kang, Lu Wang, Farhid Hemmatzadeh, Qingyun Zheng, Chen Ling, Liqing Zhu, Bicui Zhan   +12 more
doaj   +1 more source

Adeno-associated virus mediated expression of human erythropoietin in vitro

, 2002
AIM: To investigate the expression of human erythropoietin (hEpo) in 293 cell line using adeno-associated virus (AAV) vector, and provide information for its potential application in human gene therapy.
Zhao, XC, Diao, Y, Wang, GJ, Xu, RA
core  

Adeno-associated virus-mediated neuroglobin overexpression ameliorates the N-methyl-N-nitrosourea-induced retinal impairments: a novel therapeutic strategy against photoreceptor degeneration

Therapeutics and Clinical Risk Management, 2017
Ye Tao,1,* Zhen Yang,2,* Wei Fang,2 Zhao Ma,3 Yi Fei Huang,1 Zhengwei Li4 1Department of Ophthalmology, Key Lab of Ophthalmology and Visual Science, Chinese PLA General Hospital, Beijing, 2Department of Neurosurgery, Institute for Functional Brain ...
Tao Y, Yang Z, Fang W, Ma Z, Huang YF, Li Z   +5 more
doaj  

Effectiveness of resveratrol in inducing adeno-associated virus as a potential definitive therapy for SCN5A mutation in Brugada syndrome: a narrative review

The Egyptian Heart Journal
Objectives Brugada syndrome (BrS) is a hereditary channelopathy that affects cardiac electrical signal transmission, with SCN5A gene mutation being the most common cause.
Andin Zahrani Pateda, Andi Alika Azzahra, Kuni Zakiyyah Sumargo, Muchtar Nora Ismail Siregar   +3 more
doaj   +1 more source