Results 141 to 150 of about 115,653 (351)

VEGFC/VEGFR3 Signaling‐Dependent Lymphatic Remodeling Modulates Cardiac Response to Pressure Overload

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Cardiac lymphangiogenesis has been proposed as a potential therapeutic target to prevent the development of heart failure. However, the efficiency of systemically delivered VEGFC (vascular endothelial growth factor C) protein in inducing ...
Lina Su, Yuxia Cui, Manyan Wu, Shiran Yu, Chunying Zhang, Ziqi Song, Shuolei Li, Hang Lin, Zheng Lian, Chongyou Lee, Chuanfen Liu, Sufang Li, Junxian Song, Hong Chen   +13 more
doaj   +1 more source

Dissection and optimization of Adeno-associated virus (AAV) DNA family shuffling technology: The journey is the reward [PDF]

, 2018
Anne-Kathrin Herrmann
openalex   +1 more source

Contribution of Gli1+ Adventitial Stem Cells to Smooth Muscle Cells in Atherosclerosis and Vascular Injury

Advanced Science, EarlyView.
Gli1+ adventitial stem cells (ASCs) have been thought to generate smooth muscle cells (SMCs) in atherosclerosis. Using a dual‐recombinase lineage tracing to exclude ectopic labeling, Wang et al. found that Gli1+ ASCs do not contribute to SMCs in atherosclerotic plaques.
Haixiao Wang, Xiuzhen Huang, Jialing Mou, Enci Wang, Yan Li, Wenjuan Pu, Yao Xie, Xiaoling Guo, Lixin Wang, Maoping Chu, Bin Zhou, Chao Niu   +11 more
wiley   +1 more source

Reduced rAAV interference enhances rcAAV detection sensitivity

Molecular Therapy: Methods & Clinical Development
Replication-competent adeno-associated virus (rcAAV) content is a crucial contaminant in the process of recombinant adeno-associated virus (rAAV) production in gene therapy products, from preclinical to clinical stages.
Ming Yang, Sana Shaheen, Keying Yang, Xuxia Gao, Kaiwen Wu, Xiangying Zhu, Qian Kang, Lu Wang, Farhid Hemmatzadeh, Qingyun Zheng, Chen Ling, Liqing Zhu, Bicui Zhan   +12 more
doaj   +1 more source

582. Formation of Recombinant Adeno-Associated Virus Polylysine Conjugates Enables Transduction of Human Hematopoeitic Progenitor Cells [PDF]

, 2002

openalex   +1 more source

NUSAP1 Recruits DAXX to Suppress HIF‐Driven Triple‐Negative Breast Cancer Progression

Advanced Science, EarlyView.
A double‐negative feedback loop is identified in TNBC where NUSAP1 bridges HIF and DAXX via its microtubule‐associated domain (MAD) to recruit SETDB1, repressing HIF transcriptional activity by depositing the H3K9me3 repressive mark on HIF target genes, while HIF itself suppresses NUSAP1.
Yating Du, Jingjing Wang, Min Wang, Yao Zhang, Miaomiao Zheng, Huiyan Li, Xuemeng Wang, Huanran Sun, Kexin Tang, Changliang Shan, Qiang Zhao, Xiaoqian Meng, Yijie Wang, Jun Zhou, Yan Chen   +14 more
wiley   +1 more source

Metagenomic and transcriptomic investigation of pediatric acute liver failure cases reveals a common pathway predominated by monocytes

mBio
In 2022, a cluster of severe childhood hepatitis was detected primarily in Europe and North America, leading to a global alert by the World Health Organization.
Ruben H. de Kleine, Ellen C. Carbo, Willem S. Lexmond, Xuewei W. Zhou, Alicia de Kroon, Hailiang Mei, Sander T. H. Bontemps, Rick Hennevelt, Lilli Gard, Igor A. Sidorov, Stefan A. Boers, Marius C. van den Heuvel, Emilie P. Buddingh, Aloys C. M. Kroes, Vincent E. de Meijer, Elisabeth H. Schölvinck, Karin J. von Eije, Simon P. Jochems, Jutte J. C. de Vries   +18 more
doaj   +1 more source

A link between severe hepatitis in children and adenovirus 41 and adeno-associated virus 2 infections

, 2022
Roger J.A. Grand
openalex   +1 more source

Forsythoside E Alleviates Liver Injury by Targeting PKM2 Tetramerization to Promote Macrophage M2 Polarization

Advanced Science, EarlyView.
Here, the study shows for the first time that Forsythoside E (FE) can promote PKM2 tetramerization by binding to its K311 site. Furthermore, it induces metabolic reprogramming of macrophages and inhibits NLRP3 expression. Finally, it can alleviate sepsis‐induced liver injury by promoting M2 anti‐inflammatory polarization.
Bingxin Wu, Xuechun Yu, Yanling Li, Lin An, Rongrong Zhang, Rong Zhang, Fan Zhang, Zhongqiu Liu, Caiyan Wang   +8 more
wiley   +1 more source

Enhanced Transgene Expression from Recombinant Single-Stranded D-Sequence-Substituted Adeno-Associated Virus Vectors in Human Cell Lines In Vitro and in Murine Hepatocytes In Vivo [PDF]

, 2014
Chen Ling, Yuan Wang, Yuan Lu, Lina Wang, Giridhara R. Jayandharan, George Aslanidi, Baozheng Li, Binbin Cheng, Wenqin Ma, Thomas B. Lentz, Changquan Ling, Xiao Xiao, R. Jude Samulski, Nicholas Muzyczka, Arun Srivastava   +14 more
openalex   +1 more source