Results 171 to 180 of about 214,719 (303)

An Improved Method for Determining the Infection Titer of Replication-Competent Adeno-Associated Virus. [PDF]

Biomedicines
Fu J, Yu L, Fu Z, Wang G, Liang C, Shi X, Zhang Y.   +6 more
europepmc   +1 more source

Characterization of adeno-associated virus binding to alginate and its controlled release. [PDF]

Nanoscale Adv
Amante JJ, Mandeville JR, Hargrove H, Zhang XF, Kearney CJ.   +4 more
europepmc   +1 more source

Roles of histone lysine methylation in neurodevelopment and related disorders

Ibrain, EarlyView.
This graphical abstract centers on the theme of dynamic balance and systematically outlines the role of histone lysine methylation in neurodevelopment and related disorders. The figure first presents two key classes of regulators that control this balance—“writers” and “erasers”—and then indicates how interactions among different epigenetic ...
Yun Chen, Yi Zhang, Hong Zhang, Xiaoli Liang   +3 more
wiley   +1 more source

Continuous production of recombinant adeno-associated virus in the insect cell/baculovirus expression vector system. [PDF]

Mol Ther Adv
Joseph J, Destro F, Yuan A, Antov D, Chen W, Song S, Theriault M, Yuan C, Sansom A, Lundin C, Burns T, Hamed HA, Morales P, Fan JX, Rodriguez AR, Sichuma S, McCracken C, Neufeld C, Wolfrum JM, Srinivasan P, Barone PW, Sinskey AJ, Braatz RD, Springs SL.   +23 more
europepmc   +1 more source

Generation of Allogeneic CAR‐T Circumvents Functional Deficits in Patient‐Derived Autologous Product for Glioblastoma

International Journal of Cancer, EarlyView.
Clinical trials of chimeric antigen receptor T‐cell (CAR‐T) therapies in glioblastoma have shown limited clinical benefits. Whether this may be explained by the basal quality of CAR‐T products, which are currently generated using patient, autologous T‐cells, has been little explored.
Sabra K. Salim, Muhammad Vaseem Shaikh, Jeffrey Wei, William T. Maich, Alisha Anand, Oliver Y. Tang, Minomi K. Subapanditha, Zahra Alizada, Yujin Suk, Manoj Singh, Kui Zhai, Aapti Khanna, Benjamin Brakel, Vassil Dimitrov, Zoya Tabunshchyk, Katie Chan, Kevin R. Brown, Parvez Vora, Donald M. O'Rourke, Zev A. Binder, Chitra Venugopal, Jason Moffat, Sheila K. Singh   +22 more
wiley   +1 more source

Hemophilia B gene therapy: a NAb-solute barrier overcome by adeno-associated virus serotype 5. [PDF]

Res Pract Thromb Haemost
Kaczmarek R.
europepmc   +1 more source

Encryption of adeno-associated viruses with enzymatically decoded peptide locks

, 2018
The present invention is a peptide lock that comprises at least one peptide that is genetically encoded into the Adeno-associated virus (AAV) capsid that block biologically active domains on the virus capsid surface. The peptide lock, can be processed by
Suh, Junghae, Silberg, Jonathan, Judd, Justin   +2 more
core  

Decidual macrophage‐mediated ferroptosis in trophoblasts leads to recurrent spontaneous abortion

iMeta, EarlyView.
Decidual macrophages from recurrent spontaneous abortion (RSA) patients promote trophoblast ferroptosis and impair trophoblast cell function. Mechanistically, the CXCL2/NF‐κB/HMOX1 axis mediates this effect. Conversely, trophoblasts co‐cultured with RSA decidual macrophages induce pro‐inflammatory macrophage polarization through IL‐6/JAK2/STAT3 ...
Xin Chen, Xueqin Ma, Pengcheng Pang, Heng Zhou, Ruohan Li, Yan He, Yan Zhang, Jing Yang, Qianlin Song, Qingsong Ye   +9 more
wiley   +1 more source

Lyophilization of Adeno-Associated Virus Serotypes for Storage and Global Distribution. [PDF]

Biomedicines
McGlinch EB, Mudrick HE, Evans CH, Barry MA.   +3 more
europepmc   +1 more source

Sel1l preserves condylar cartilage matrix homeostasis by regulating PERK signaling

Interdisciplinary Medicine, EarlyView.
Our study revealed that the expression of Sel1l was downregulated in OA cartilage and that Sel1l deficiency induced cartilage catabolism. Mechanistically, Sel1l depletion aberrantly activated PERK signaling and resulted in ER stress. PERK inhibition rescued the phenotype of Sel1l‐deficient chondrocytes and alleviated TMJOA pathogenesis.
Xinqi Huang, Zinan Cen, Zhihe Zhao, Xiao Cen   +3 more
wiley   +1 more source