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Development and Characterization of Adeno-Associated Virus-Loaded Coaxial Electrospun Scaffolds for Potential Viral Vector Delivery. [PDF]

Polymers (Basel)
Zhang H, Zhou B, Dong W, Song Y, Hu Q, Zhang H, Yu M, Zhu G, Sun Y, Feng J.   +9 more
europepmc   +1 more source

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Adeno-associated virus autointerference

Virology, 1979
We have analyzed an autointerference phenomenon exhibited by adeno-associated virus type 2 (AAV) when grown in KB cells coinfected with adenovirus type 2 as the helper. Infectious AAV particles that banded at 1.41 g/cm3 in CsCl were purified by three cycles of centrifuging in CsCl equilibrium gradients.
B J, Carter, C A, Laughlin, L M, de la Maza, M, Myers   +3 more
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Assembly of adeno-associated virus

Virology, 1980
Abstract The assembly of the defective parvovirus, adeno-associated virus (AAV), was studied by labeling DNA and protein precursors with [3H]thymidine or [35S]methionine, respectively. Virus particles were extracted from cell lysates and characterized by banding to equilibrium in CsCl gradients and by velocity sedimentation in neutral sucrose ...
M W, Myers, B J, Carter
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Adeno-Associated Virus Vector Design–Moving the Adeno-Associated Virus to a Bioengineered Therapeutic Nanoparticle

Hematology/Oncology Clinics of North America, 2022
Although the number of market-approved gene therapies is still low, this new class of therapeutics has become an integral part of modern medicine. The success and safety of gene therapy depend on the vectors used to deliver the therapeutic material. Adeno-associated virus (AAV) vectors have emerged as the most frequently used delivery system for in ...
Nico, Jäschke, Hildegard, Büning
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The Genetics of Adeno-Associated Virus

1984
Adeno-associated virus (AAV) is a defective parvovirus which is absolutely dependent on coinfection with a helper virus for a productive lytic cycle (for a review, see ref. 1). Either adenoviruses or herpes viruses can act as helpers (2–5) . In the absence of a helper virus, AAV efficiently integrates into host cell chromosomes via its inverted ...
N, Muzyczka, R J, Samulski, P, Hermonat, A, Srivastava, K I, Berns   +4 more
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Biology of Adeno-associated Virus

1996
Adeno-associated Virus (AAV) is classified as a member of the family Parvoviridae (Siegl et al. 1985; Berns 1990a). Members are small, nonenveloped, icosahedral viruses (diameter ca. 20–26 nm) with linear, single-stranded DNA genomes of 4.7–6 kb. Parvoviridae have been isolated from many species ranging from insects to humans.
K I, Berns, C, Giraud
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Adeno-Associated Virus Biology

2011
Adeno-associated virus (AAV) was first discovered as a contaminant of adenovirus stocks in the 1960s. The development of recombinant AAV vectors (rAAV) was facilitated by early studies that generated infectious molecular clones, determined the sequence of the genome, and defined the genetic elements of the virus. The refinement of methods and protocols
Weitzman, Matthew D, Linden, R Michael
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Adeno-associated virus vectors

Current Biology, 1992
Adeno-associated virus is a human parvovirus that integrates its DNA genome into host cell chromosomes with very high efficiency. This suggests that adeno-associated virus may be a useful vector for human gene therapy. Interest in adeno-associated virus vectors increased greatly in the last year following reports that adeno-associated virus genome ...
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