Results 301 to 310 of about 116,785 (352)

Real-time genome imaging of host interactions in adeno-associated virus genome release. [PDF]

iScience
Bustamante-Jaramillo LF, Yue L, Fingal J, Rydell G, Johansson M, Edreira T, Müller OJ, Hille S, Müller M, Gallardo F, Chen Q, Blondot ML, Kann M.   +12 more
europepmc   +1 more source

Advancing adeno-associated virus for Duchenne muscular dystrophy treatment: Moving beyond rodent models. [PDF]

Mol Ther Methods Clin Dev
Ikotun OF, McNally EM, Spencer MJ.
europepmc   +1 more source

Adeno-Associated Virus 2 (AAV2) - Induced RPA exhaustion generates cellular DNA damage and restricts viral gene expression. [PDF]

PLoS Pathog
Summers MF, Haubold MK, Morgenstern M, Shepherd P, Larsen CIS, Bartz AE, Thirumoorthy G, Kirchdoerfer RN, Coon JJ, Mehta KPM, Majumder K.   +10 more
europepmc   +1 more source

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Adeno-associated virus autointerference

Virology, 1979
We have analyzed an autointerference phenomenon exhibited by adeno-associated virus type 2 (AAV) when grown in KB cells coinfected with adenovirus type 2 as the helper. Infectious AAV particles that banded at 1.41 g/cm3 in CsCl were purified by three cycles of centrifuging in CsCl equilibrium gradients.
B J, Carter, C A, Laughlin, L M, de la Maza, M, Myers   +3 more
openaire   +2 more sources

Adeno-Associated Virus Biology

2011
Adeno-associated virus (AAV) was first discovered as a contaminant of adenovirus stocks in the 1960s. The development of recombinant AAV vectors (rAAV) was facilitated by early studies that generated infectious molecular clones, determined the sequence of the genome, and defined the genetic elements of the virus. The refinement of methods and protocols
Weitzman, Matthew D, Linden, R Michael
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Assembly of adeno-associated virus

Virology, 1980
Abstract The assembly of the defective parvovirus, adeno-associated virus (AAV), was studied by labeling DNA and protein precursors with [3H]thymidine or [35S]methionine, respectively. Virus particles were extracted from cell lysates and characterized by banding to equilibrium in CsCl gradients and by velocity sedimentation in neutral sucrose ...
M W, Myers, B J, Carter
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Adeno-associated virus vectors

Current Biology, 1992
Adeno-associated virus is a human parvovirus that integrates its DNA genome into host cell chromosomes with very high efficiency. This suggests that adeno-associated virus may be a useful vector for human gene therapy. Interest in adeno-associated virus vectors increased greatly in the last year following reports that adeno-associated virus genome ...
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Adeno-Associated Virus-Mediated Gene Therapy

Critical Reviews in Eukaryotic Gene Expression, 2023
Choice of vector is the most critical step in gene therapy. Adeno-associated viruses (AAV); third generation vectors, are getting much attention of scientists to be used as vehicles due to their non-pathogenicity, excellent safety profile, low immune responses, great efficiency to transduce non-dividing cells, large capacity to transfer genetic ...
Hassan, Zaman, Aakif, Khan, Khalid, Khan, Shazma, Toheed, Muhammad, Abdullah, Hafiz Muhammad, Zeeshan, Abdul, Hameed, Muhammad, Umar, Muhammad, Shahid, Kausar, Malik, Samia, Afzal   +10 more
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Adenovirus–Adeno-Associated Virus Hybrid for Large-Scale Recombinant Adeno-Associated Virus Production

Human Gene Therapy, 2009
Recombinant adeno-associated virus (rAAV) holds promise for applications in gene therapy. Advances in clinical studies of rAAV-based gene therapeutics have generated an encouraging momentum in the field of gene therapy; however, one of the major obstacles to the eventual clinical success of rAAV-mediated gene therapy is the need for large-scale ...
Hongwei, Zhang, Jun, Xie, Qing, Xie, James M, Wilson, Guangping, Gao   +4 more
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