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Adenovirus and Adeno-Associated Virus Vectors
DNA and Cell Biology, 2002Recombinant adenovirus (rAd) and recombinant adeno-associated virus (rAAV) are among the most extensively used vectors in gene therapy studies to date. These two vectors share some similar features such as a broad host range and ability to infect both proliferating and quiescent cells.
Chooi May, Lai +2 more
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Processing of adeno-associated virus RNA
Frontiers in Bioscience, 2008Adeno-associated viruses (AAVs), members of the Dependovirus genus of the subfamily Parvovirinae, family Parvoviridae, have single-stranded DNA genomes that replicate via a double-stranded DNA intermediate which serves as the transcription template. They exhibit a highly compact, overlapping genetic organization which is surprisingly variable amongst ...
Jianming, Qiu, David, Pintel
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Human Gene Therapy, 2009
Recombinant adeno-associated virus (rAAV) holds promise for applications in gene therapy. Advances in clinical studies of rAAV-based gene therapeutics have generated an encouraging momentum in the field of gene therapy; however, one of the major obstacles to the eventual clinical success of rAAV-mediated gene therapy is the need for large-scale ...
Hongwei, Zhang +4 more
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Recombinant adeno-associated virus (rAAV) holds promise for applications in gene therapy. Advances in clinical studies of rAAV-based gene therapeutics have generated an encouraging momentum in the field of gene therapy; however, one of the major obstacles to the eventual clinical success of rAAV-mediated gene therapy is the need for large-scale ...
Hongwei, Zhang +4 more
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Multimodal Production of Adeno-Associated Virus
2019Adeno-associated virus (AAV) is an increasingly popular tool in the research laboratory, and use of this viral vector clinically is occurring at an accelerated pace. Nevertheless, despite its popularity, AAV is a relatively cumbersome virus to produce; however, significant efforts have been invested to develop, optimize, and simplify methodology that ...
Ivette M, Sandoval +2 more
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1984
Adeno-associated virus (AAV) was discovered as a contaminant of purified adenovirus preparations. Although the small icosahedral particles (diameter 18–28 nm) were initially considered to be either precursors to the mature adenovirus particle or breakdown products of the virion, they were rapidly demonstrated to represent a distinct virus that was ...
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Adeno-associated virus (AAV) was discovered as a contaminant of purified adenovirus preparations. Although the small icosahedral particles (diameter 18–28 nm) were initially considered to be either precursors to the mature adenovirus particle or breakdown products of the virion, they were rapidly demonstrated to represent a distinct virus that was ...
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Analysis of adeno-associated satellite virus DNA
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1973Abstract Adeno-associated satellite viruses (ASV) cannot replicate unless host cells are coinfected with competent adenoviruses. During replication both satellite virus DNA and adenovirus DNA are produced and the system is difficult to dissect at the molecular level.
H D, Mayor, J, Ratner
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ADENOVIRUS, ADENO-ASSOCIATED VIRUS AND KAWASAKI DISEASE
The Pediatric Infectious Disease Journal, 2005Clinical similarities and shared seasonality suggested a relationship between adenovirus infection and Kawasaki disease. We performed adenovirus serology and quantitative polymerase chain reaction for both adenovirus and adeno-associated virus in patients with acute Kawasaki disease.
Hiroko, Shike +6 more
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Adeno-Associated Virus (AAV) Vectors in the CNS
Current Gene Therapy, 2005Adeno-associated virus (AAV) vectors exhibit a number of properties that have made this vector system an excellent choice for both CNS gene therapy and basic neurobiological investigations. In vivo, the preponderance of AAV vector transduction occurs in neurons where it is possible to obtain long-term, stable gene expression with very little ...
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Generation of Recombinant Adeno-Associated Virus
2003Adeno-associated virus (AAV) was discovered about 30 yr ago as a contaminant of adenovirus preparations. Since its discovery, researchers have described many unique characteristics of AAV biology that have made it attractive as a potential vector for gene therapy.
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Analysis of Adeno-Associated Virus and HPV Interaction
2005It is slowly becoming accepted that adeno-associated virus (AAV) is another significant factor involved in cervical carcinogenesis. However, unlike human papillomavirus (HPV), which is positively associated with cervical cancer, AAV is negatively associated with this cancer.
Paul L, Hermonat +3 more
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