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Adeno-associated virus autointerference
Virology, 1979We have analyzed an autointerference phenomenon exhibited by adeno-associated virus type 2 (AAV) when grown in KB cells coinfected with adenovirus type 2 as the helper. Infectious AAV particles that banded at 1.41 g/cm3 in CsCl were purified by three cycles of centrifuging in CsCl equilibrium gradients.
Barrie J. Carter +3 more
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Adeno-Associated Virus Biology
2011Adeno-associated virus (AAV) was first discovered as a contaminant of adenovirus stocks in the 1960s. The development of recombinant AAV vectors (rAAV) was facilitated by early studies that generated infectious molecular clones, determined the sequence of the genome, and defined the genetic elements of the virus. The refinement of methods and protocols
Weitzman, Matthew D, Linden, R Michael
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Hematology/Oncology Clinics of North America, 2022
Although the number of market-approved gene therapies is still low, this new class of therapeutics has become an integral part of modern medicine. The success and safety of gene therapy depend on the vectors used to deliver the therapeutic material. Adeno-associated virus (AAV) vectors have emerged as the most frequently used delivery system for in ...
Nico, Jäschke, Hildegard, Büning
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Although the number of market-approved gene therapies is still low, this new class of therapeutics has become an integral part of modern medicine. The success and safety of gene therapy depend on the vectors used to deliver the therapeutic material. Adeno-associated virus (AAV) vectors have emerged as the most frequently used delivery system for in ...
Nico, Jäschke, Hildegard, Büning
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Biotechnology Journal, 2020
For adeno‐associated virus (AAV)‐based human gene therapy, challenges for the translation of promising research results to successful clinical development include optimization of vector design and manufacturing processes to ensure that vectors prepared ...
J. F. Wright
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For adeno‐associated virus (AAV)‐based human gene therapy, challenges for the translation of promising research results to successful clinical development include optimization of vector design and manufacturing processes to ensure that vectors prepared ...
J. F. Wright
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The Genetics of Adeno-Associated Virus
1984Adeno-associated virus (AAV) is a defective parvovirus which is absolutely dependent on coinfection with a helper virus for a productive lytic cycle (for a review, see ref. 1). Either adenoviruses or herpes viruses can act as helpers (2–5) . In the absence of a helper virus, AAV efficiently integrates into host cell chromosomes via its inverted ...
Richard Jude Samulski +4 more
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Adeno-associated virus vectors
Current Biology, 1992Adeno-associated virus is a human parvovirus that integrates its DNA genome into host cell chromosomes with very high efficiency. This suggests that adeno-associated virus may be a useful vector for human gene therapy. Interest in adeno-associated virus vectors increased greatly in the last year following reports that adeno-associated virus genome ...
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Biology of Adeno-associated Virus
1996Adeno-associated Virus (AAV) is classified as a member of the family Parvoviridae (Siegl et al. 1985; Berns 1990a). Members are small, nonenveloped, icosahedral viruses (diameter ca. 20–26 nm) with linear, single-stranded DNA genomes of 4.7–6 kb. Parvoviridae have been isolated from many species ranging from insects to humans.
C Giraud, Kenneth I. Berns
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, 1984 Adeno-associated virus (AAV) was discovered as a contaminant of purified adenovirus preparations. Although the small icosahedral particles (diameter 18–28 nm) were initially considered to be either precursors to the mature adenovirus particle or breakdown products of the virion, they were rapidly demonstrated to represent a distinct virus that was ...
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Adenovirus and Adeno-Associated Virus Vectors
DNA and Cell Biology, 2002Recombinant adenovirus (rAd) and recombinant adeno-associated virus (rAAV) are among the most extensively used vectors in gene therapy studies to date. These two vectors share some similar features such as a broad host range and ability to infect both proliferating and quiescent cells.
P. Elizabeth Rakoczy +2 more
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Processing of adeno-associated virus RNA
Frontiers in Bioscience, 2008Adeno-associated viruses (AAVs), members of the Dependovirus genus of the subfamily Parvovirinae, family Parvoviridae, have single-stranded DNA genomes that replicate via a double-stranded DNA intermediate which serves as the transcription template. They exhibit a highly compact, overlapping genetic organization which is surprisingly variable amongst ...
David Pintel, Jianming Qiu
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