Results 361 to 370 of about 396,665 (375)

Adenovirus–Adeno-Associated Virus Hybrid for Large-Scale Recombinant Adeno-Associated Virus Production

Human Gene Therapy, 2009
Recombinant adeno-associated virus (rAAV) holds promise for applications in gene therapy. Advances in clinical studies of rAAV-based gene therapeutics have generated an encouraging momentum in the field of gene therapy; however, one of the major obstacles to the eventual clinical success of rAAV-mediated gene therapy is the need for large-scale ...
Hongwei Zhang, Guangping Gao, James M. Wilson, Jun Xie, Qing Xie   +4 more
openaire   +3 more sources

Production of recombinant adeno-associated virus

2000
Currently, rAAV appears to be one of the most promising vectors for gene therapy applications. Attractive features of the vector include nonpathogenicity, the ability to infect nondividing cells, escape from host immune responses, and integration into the host genome.
Guangping Gao, James M. Wilson, Nelson A. Wivel   +2 more
openaire   +3 more sources

Directed evolution of adeno-associated virus for efficient gene delivery to microglia

Nature Methods, 2022
R. Lin, Youtong Zhou, Ting Yan, Ruiyu Wang, Heng Li, Zhaofa Wu, Xinshuang Zhang, Xiangyu Zhou, Fei Zhao, Li Zhang, Yulong Li, Minmin Luo   +11 more
semanticscholar   +1 more source

Adeno-Associated Virus (AAV) Vectors in the CNS

Current Gene Therapy, 2005
Adeno-associated virus (AAV) vectors exhibit a number of properties that have made this vector system an excellent choice for both CNS gene therapy and basic neurobiological investigations. In vivo, the preponderance of AAV vector transduction occurs in neurons where it is possible to obtain long-term, stable gene expression with very little ...
openaire   +3 more sources

Variants of the adeno-associated virus serotype 9 with enhanced penetration of the blood–brain barrier in rodents and primates

Nature Biomedical Engineering, 2022
Yizheng Yao, Jun Wang, Yi Liu, Yuan Qu, Kaikai Wang, Yang Zhang, Yu-Yun Chang, Zhi Yang, Jie Wan, Junfeng Liu, H. Nakashima, S. Lawler, E. Chiocca, C. Cho, F. Bei   +14 more
semanticscholar   +1 more source

Analysis of adeno-associated satellite virus DNA

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1973
Abstract Adeno-associated satellite viruses (ASV) cannot replicate unless host cells are coinfected with competent adenoviruses. During replication both satellite virus DNA and adenovirus DNA are produced and the system is difficult to dissect at the molecular level.
H.D. Mayor, J. Ratner
openaire   +3 more sources

Engineering adeno-associated virus vectors for gene therapy

Nature reviews genetics, 2020
Chengwen Li, R. Samulski
semanticscholar   +1 more source

Generation of Recombinant Adeno-Associated Virus

2003
Adeno-associated virus (AAV) was discovered about 30 yr ago as a contaminant of adenovirus preparations. Since its discovery, researchers have described many unique characteristics of AAV biology that have made it attractive as a potential vector for gene therapy.
openaire   +3 more sources

Adeno-Associated Virus

2002
Yongping Yue, John F. Engelhardt, Dongsheng Duan   +2 more
openaire   +2 more sources

Cloning of the Adeno-Associated Virus Genome

1984
The adeno-associated viruses (AAV) are defective parvoviruses that are dependent on coinfection with either adenovirus or herpesvirus for replication to occur (1–4). AAV has a linear single-strand DNA genome and is unusual in that strands of both polarities are encapsidated with equal frequency into separate virions (5,6).
openaire   +2 more sources