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An Alternate Route for Adeno-Associated Virus (AAV) Entry Independent of AAV Receptor. [PDF]
Journal of Virology, 2018 ABSTRACT Determinants and mechanisms of cell attachment and entry steer adeno-associated virus (AAV) in its utility as a gene therapy vector. Thus far, a systematic assessment of how diverse AAV serotypes engage their proteinaceous receptor AAVR (KIAA0319L) to establish transduction has been lacking, despite ...
Jianming Qiu +2 more
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Integration of Adeno-Associated Virus (AAV) and Recombinant AAV Vectors
Annual Review of Genetics, 2004▪ Abstract The driving interest in adeno-associated virus (AAV) has been its potential as a gene delivery vector. The early observation that AAV can establish a latent infection by integrating into the host chromosome has been central to this interest. However, chromosomal integration is a two-edged sword, imparting on one hand the ability to maintain
Douglas M, McCarty +2 more
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Construction of Recombinant Adeno-Associated Virus (AAV)
2003Efficient and stable transfer of foreign DNA into cells both in vitro and in vivo has become a powerful tool in the study of the pathogeneses of various diseases, such as cancer and infectious diseases. The study of hepatitis C virus (HCV) pathogenesis has been hampered by the lack of an easily available animal model or in vitro replication system.
M, Reiser, S, Zolotukhin
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Adeno-Associated Virus (AAV) Vectors in the CNS
Current Gene Therapy, 2005Adeno-associated virus (AAV) vectors exhibit a number of properties that have made this vector system an excellent choice for both CNS gene therapy and basic neurobiological investigations. In vivo, the preponderance of AAV vector transduction occurs in neurons where it is possible to obtain long-term, stable gene expression with very little ...
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Adeno-Associated Virus (AAV) Gene Therapy for Neurological Disease
Neuropharmacology, 2013 Diseases of the central nervous system (CNS) have provided enormous opportunities for the therapeutic application of viral vector gene transfer. Adeno-associated virus (AAV) has been the vector of choice in recent clinical trials of neurological disease, including Parkinson's and Alzheimer's disease, due to the safety, efficacy, and stability of AAV ...
Thomas J McCown +2 more
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Boosters for adeno-associated virus (AAV) vector (r)evolution
Cytotherapy, 2023Adeno-associated virus (AAV) is one of the most exciting and most versatile templates for engineering of gene-delivery vectors for use in human gene therapy, owing to the existence of numerous naturally occurring capsid variants and their amenability to directed molecular evolution.
Joanna, Szumska, Dirk, Grimm
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Genome Engineering Using Adeno-Associated Virus (AAV)
2014The ability to edit the genome of cell lines has provided valuable insights into biological processes and the contribution of specific mutations to disease biology. These techniques fall into two categories based on the DNA repair mechanism that is used to incorporate the genetic change.
Rob, Howes, Christine, Schofield
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Prevalence and characterisation of adeno-associated virus (AAV)
2017Das Adeno-assoziierte Virus (AAV) ist allgegenwärtig, ist aber bisher mit keiner menschlichen Erkrankung in Verbindung gebracht worden. Als Dependovirus hat es einen zweiphasigen AAV-Lebenszyklus mit einer Latenzphase und einer Helfervirus-induzierten produktiven Replikationsphase.
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Standardisation in the Analytical Characterization of Adeno-Associated Virus (AAV) Vectors
Journal of Visualized ExperimentsAdeno-associated virus (AAV) has become a leading vector for in vivo gene therapy, with eight products currently holding marketing authorization. As the field rapidly evolves, the need for robust analytical methods to characterize critical quality attributes (CQAs)-including capsid titer, genome titer, capsid content (empty/full ratio), identity, and ...
Saleheen, Khan +2 more
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Recombinant Adeno-Associated Virus (r AAV) Vectors
1999Adeno-associated virus (AAV) is a single-stranded DNA dependovirus of the family of Parvoviridae which has promising features as a vector for somatic gene therapy. Different recombinant (r) AAV vectors have been generated which seem to have some advantages in comparison with other vectors, like the ability to transduce terminally differentiated and non-
M. Hallek +4 more
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