Results 161 to 170 of about 387,731 (304)

Local Anesthetics in Cancer: Mechanisms and Translational Perspectives

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang, Tu Huang, Yi‐hang Hao, Min Zheng, Xin‐hua Liang   +4 more
wiley   +1 more source

Mucinous adenocarcinoma in kidneys with developmental anomalies - a report of two cases

BMC Urology
Background Primary mucinous adenocarcinomas of the kidney are rare and pose a challenge for preoperative diagnosis. The histogenesis of these tumours remains largely unknown, with three proposed theories: chronic irritation, differentiation of celomic ...
Kasi Viswanath Gali, Arun Chawla, K. R. Surag, Sunil Pillai Bhaskara, Padmaraj Hegde   +4 more
doaj   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

[Adenocarcinoma of the appendix in Iceland 1990-2009. A population based study]. [PDF]

, 2011
Adenocarcinoma of the appendix is less than 0.5% of all gastrointestinal cancers. The aim of this study was to analyse the incidence, symptoms, pathology and treatment of appendiceal adenocarcinoma in a well defined cohort as well as the prognosis of the
Halla Viðarsdóttir, Jón Gunnlaugur Jónasson, Páll Helgi Möller   +2 more
core  

Diagnostic Accuracy of O‐RADS US, IOTA Simple Rules, Subjective Assessment, and the Sequential IOTA Simple Rules–Subjective Assessment (SR–SA) Strategy in Adnexal Masses: High Sensitivity Versus the Challenge of Specificity in a Middle‐Resource Setting

Sonography, Volume 13, Issue 1, March 2026.
ABSTRACT Objectives To compare four ultrasound models: O‐RADS US, IOTA Simple Rules (SR), Subjective Assessment (SA), and the Sequential SR–Subjective Assessment strategy (SR–SA) for classifying adnexal masses and to assess whether additional discrimination is possible within intermediate‐risk O‐RADS 3 lesions in a middle‐resource setting.
Carolina Meloni Stecca, Paula Meneguini Badran, Maira Furtado Greco Mazzer, Rodrigo Menezes Jales   +3 more
wiley   +1 more source

Protein tyrosine phosphatases as emerging targets for cancer immunotherapy

British Journal of Pharmacology, Volume 183, Issue 6, Page 1233-1249, March 2026.
Abstract Contemporary strategies in cancer immunotherapy, despite remarkable success, remain constrained by inherent limitations such as suboptimal patient responses, the emergence of drug resistance, and the manifestation of pronounced adverse effects. Consequently, the need for alternative strategies for immunotherapy becomes clear.
Zihan Qu, Jiajun Dong, Zhong‐Yin Zhang
wiley   +1 more source

What the Eyelid Can Tell You: The Unexpected Initial Presentation of De Novo Stage IV Breast Carcinoma

Journal of Cutaneous Pathology, Volume 53, Issue 3, Page 248-253, March 2026.
ABSTRACT A 66‐year‐old female presented with seven months of progressive right upper eyelid (RUL) drooping and thickening of her right lower eyelid (RLL). MRI revealed soft tissue enhancement of the RUL and RLL pre‐septal planes without posterior extension.
Grace L. Casado, Eileen Xu, Maedot A. Haymete, Nicholas A. Ramey, Douglas J. Grider   +4 more
wiley   +1 more source

Interobserver variability of histopathological assessment in pT1 colorectal carcinoma

Histopathology, Volume 88, Issue 4, Page 868-880, March 2026.
Interobserver variability among 20 gastrointestinal pathologists was evaluated on 80 pT1 colorectal carcinoma cases. A pilot phase was followed by a consensus meeting, then a larger concordance study was performed. High interobserver agreement was achieved after consensus for histological grade, lymphovascular invasion, tumour budding, poorly ...
Karmele Saez de Gordoa, María Daca‐Alvarez, Maite Rodrigo‐Calvo, Ivan Archilla, Sandra Lopez‐Prades, Jose Javier Aguirre, Lorena Alarcón‐Molero, María Cámara Jurado, Adriana Canosa, Francisco Giner, Carmen González‐Lois, Mireya Jimeno, Ismael Jurado, Isidro Machado, Carolina Martínez‐Ciarpaglini, Eva Musulen, Dolores Naranjo, Natalia Papaleo, Cristina Peña, Òria Rosiñol, Rosario Sánchez‐Yuste, Greissy Tibisay Vázquez Benítez, María Pellisé, Miriam Cuatrecasas, on behalf of the EpiT1 Consortium   +24 more
wiley   +1 more source

RB1 inactivation in cutaneous carcinomas

Histopathology, Volume 88, Issue 4, Page 769-789, March 2026.
Among skin carcinomas, recurrent RB1 inactivation is observed in Merkel cell carcinoma, in a subset of squamous cell carcinoma with bowenoid morphology, in sebaceous carcinoma and in the recently described Wnt/beta‐catenin rosette‐forming carcinoma.
Tiffany Liv, Antoine Touzé, David Schrama, Serge Guyétant, Mahtab Samimi, Michael T Tetzlaff, Benjamin A Wood, Paul W Harms, Thibault Kervarrec   +8 more
wiley   +1 more source

The spectrum of breast in situ papillary carcinomas with invasion and invasive breast carcinomas with papillary features: an overview of histological subtypes and diagnostic challenges

Histopathology, Volume 88, Issue 4, Page 747-768, March 2026.
Invasive breast carcinomas with papillary features (IBCP) comprise diverse subtypes with variable architecture, histopathology, and clinical behaviour. This review outlines evolving classification, diagnostic criteria, and treatment implications, highlighting challenges in distinguishing in situ from invasive lesions. Standardised diagnostic approaches
Emad A Rakha, Puay Hoon Tan, Wendy A Raymond   +2 more
wiley   +1 more source