Results 191 to 200 of about 48,384 (279)

Arid1a deficiency sensitises pancreatic cancer to fatty acid synthase inhibition

open access: yesClinical and Translational Medicine, Volume 15, Issue 7, July 2025.
Combination of Kras activation and Arid1a loss induces pancreatic cancer in mice. ARID1A deficiency enhances immune cell infiltration and lipid metabolism in pancreatic cancer. Fatty acid synthase (FASN) is a druggable target in ARID1A‐deficient pancreatic cancer.
Tzu‐Lei Kuo   +4 more
wiley   +1 more source

Multilobar massive cavitating adenocarcinoma: a case report. [PDF]

open access: yesJ Med Case Rep
Arwi G   +5 more
europepmc   +1 more source

Cancer therapy resistance from a spatial‐omics perspective

open access: yesClinical and Translational Medicine, Volume 15, Issue 7, July 2025.
Spatial omics technologies reveal unprecedented insights into cancer therapy resistance (CTR) by resolving spatial heterogeneity of tumour and microenvironment. This review highlights cutting‐edge spatial omics and computational technologies, showcasing their transformative potential in deciphering CTR mechanisms and uncovering novel diagnostic and ...
Yinghao Zhang   +6 more
wiley   +1 more source

A Case Series and Literature Review of Angiosarcoma With Malignant Effusion—A Challenging Cytologic Diagnosis With Dire Prognostic Implications

open access: yesDiagnostic Cytopathology, Volume 53, Issue 7, Page E119-E126, July 2025.
ABSTRACT Angiosarcoma with malignant effusion is an uncommon yet clinically aggressive presentation, which poses as a diagnostic pitfall with its overlapping cytomorphologic features with metastatic adenocarcinoma. In this article, two cases reported in the literature were reviewed for cytology, immunocytochemistry, and clinical course.
Jamie C. Y. Lam   +3 more
wiley   +1 more source

The Tumour Glyco‐Code: Sialylation as a Mediator of Stromal Cell Immunosuppression in the Tumour Microenvironment

open access: yesEuropean Journal of Immunology, Volume 55, Issue 7, July 2025.
The Sialic acid/Siglec axis is emerging as an important target in the TME. We explore the role of sialylation within stromal‐rich, immunosuppressive TMEs, focusing on how specific sialic acid/Siglec interactions dictate innate and adaptive immune responses.
Aoise O'Neill   +7 more
wiley   +1 more source

High-grade appendiceal mucinous neoplasms in children: a case report. [PDF]

open access: yesFront Pediatr
Wang H   +5 more
europepmc   +1 more source

Molecular Classification of Resected Primary Duodenal Adenocarcinoma

open access: yesGenes, Chromosomes and Cancer, Volume 64, Issue 7, July 2025.
ABSTRACT Introduction The molecular and histological characteristics of primary duodenal adenocarcinoma (DA) have been poorly described, which hampers the development of new treatment options. This study aimed to characterize the landscape of chromosomal copy number aberrations (CNAs), microsatellite instability status, and tumor–stroma content, and ...
Jacob de Bakker   +9 more
wiley   +1 more source

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