Results 211 to 220 of about 386,873 (322)

RNF39 promotes colorectal cancer progression by driving RINT1 degradation and suppressing ER stress‐induced apoptosis

open access: yesClinical and Translational Medicine, Volume 16, Issue 1, January 2026.
RNF39, an E3 ubiquitin ligase upregulated by MEF2D in COAD, promotes RINT1 degradation, affecting UPR and ER stress. Loss of RNF39 leads to RINT1 accumulation, enhancing CHOP expression and sensitizing cells to apoptosis. Abstract Background Colorectal adenocarcinoma (COAD) cells exploit stress‐adaptation programs, such as the unfolded protein response
Lu Chen   +7 more
wiley   +1 more source

Natural Products Targeting Notch Signaling in Cancer: Mechanistic Insights and Food‐Based Chemoprevention Potential

open access: yesFood Frontiers, Volume 7, Issue 1, January 2026.
The Notch signaling pathway plays a dual role in cancer, acting as both a tumor promoter and suppressor depending on cellular context. This review highlights how natural products modulate Notch signaling to inhibit tumor initiation, progression, angiogenesis, and cancer stem cell maintenance.
Rabab Fatima   +15 more
wiley   +1 more source

Genetic differences between primary colorectal cancer and its paired synchronous and metachronous metastases

open access: yesInternational Journal of Cancer, Volume 158, Issue 1, Page 120-130, 1 January 2026.
What's new? Colorectal cancer (CRC) frequently metastasizes to the liver, either synchronously with primary diagnosis or metachronously, after variable time intervals. Although implicated, the role of genetic factors in driving synchronous and metachronous disease progression remains uncertain.
Marie Rajtmajerova   +16 more
wiley   +1 more source

SATB2 is Rarely Expressed in Endometrial or Endocervical Carcinoma. [PDF]

open access: yesAPMIS
Amaamri-Seebach T   +4 more
europepmc   +1 more source

The Role of Macrophages in Cancer: From Basic Research to Clinical Applications

open access: yesMedComm, Volume 7, Issue 1, January 2026.
Monocytes infiltrate the tumor microenvironment (TME) and differentiate into macrophages, which polarize into proinflammatory, antitumor M1 cells or immunosuppressive, protumor M2 cells. Within the TME, M2‐type tumor‐associated macrophages (TAMs) predominate and drive tumor growth, angiogenesis, and metastasis. Therapeutic strategies therefore focus on
Zhimei Liu   +5 more
wiley   +1 more source

Low-Grade Appendiceal Mucinous Neoplasm as an Incidental Finding During Cesarean Section: A Case Report. [PDF]

open access: yesAm J Case Rep
Paunovic V   +9 more
europepmc   +1 more source

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