Results 61 to 70 of about 358,784 (300)

Gene signature driving invasive mucinous adenocarcinoma of the lung

EMBO Molecular Medicine, 2017
Though invasive mucinous adenocarcinoma of the lung (IMA) is pathologically distinctive, the molecular mechanism driving IMA is not well understood, which hampers efforts to identify therapeutic targets.
M. Guo, K. Tomoshige, M. Meister, T. Muley, T. Fukazawa, T. Tsuchiya, Rebekah A. Karns, A. Warth, I. Fink-Baldauf, T. Nagayasu, Y. Naomoto, Yan Xu, M. Mall, Yutaka Maeda   +13 more
semanticscholar   +1 more source

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray, Shehzahdi S. Moonshi, Hang Thu Ta   +2 more
wiley   +1 more source

EUS-Guided Pancreatic Cyst Ablation: a Clinical and Technical Review [PDF]

, 2019
Purpose of Review Pancreatic cystic lesions represent a growing public health dilemma, particularly as our population ages and cross-sectional imaging becomes more sensitive.
DeWitt, John M., Maranki, Jennifer L., Moyer, Matthew T.   +2 more
core   +1 more source

Biology of invasive mucinous adenocarcinoma of the lung.

Translational Lung Cancer Research, 2017
Invasive mucinous adenocarcinoma (IMA) is a unique histologic subtype of lung adenocarcinoma. Recent studies document distinctive genetic alterations (e.g., NRG1 fusions) and a "mucinous gene signature" in IMAs, as well as differences in clinical ...
Y. Cha, H. Shim
semanticscholar   +1 more source

Cholesterol Functionalized Nanoparticles Are Effective against Helicobacter pylori, the Gastric Bug: A Proof‐of‐Concept Study

Advanced Healthcare Materials, EarlyView.
Helicobacter pylori gastric infection is widespread and recurrency is common, fuelled by bacterial resistance to antibiotics. Therefore, specific and noninducing resistance alternative treatments are an urgent need. Taking advantage of this gastric pathogen auxotrophy for cholesterol, a “trojan horse” strategy for H.
Ana Sofia Pinho, Renato Pereira, Mariana Pereira, Akhilesh Rai, Lino Ferreira, Maria Cristina Lopes Martins, Paula Parreira   +6 more
wiley   +1 more source

Multifocal High-Grade Pancreatic Precursor Lesions: A Case Series and Management Recommendations [PDF]

, 2019
Background: The risk of developing invasive cancer in the remnant pancreas after resection of multifocal high-grade pancreatic precursor lesions is not well known.
Carr, Rosalie A., Roch, Alexandra M., Schmidt, Christian Max, Soufi, Mazhar, Wu, Howard H., Yip-Schneider, Michele T.   +5 more
core   +1 more source

Digitonin‐Loaded Nanoscale Metal–Organic Framework for Mitochondria‐Targeted Radiotherapy‐Radiodynamic Therapy and Disulfidptosis

Advanced Materials, EarlyView.
A mitochondria‐targeted cationic nanoscale metal organic framework shows strong radiotherapy‐radiodynamic therapy effects and selectively releases digitonin in acidic tumor microenvironments to induce disulfidptosis of cancer cells and downregulate immune checkpoints in cancer and T cells, thereby eliciting strong antitumor immunity to effectively ...
Wenyao Zhen, Yingjie Fan, Tomas Germanas, Langston Tillman, Jinhong Li, Abigail L. Blenko, Ralph R. Weichselbaum, Wenbin Lin   +7 more
wiley   +1 more source

Recent developments in biosensing methods for extracellular vesicle protein characterization

WIREs Nanomedicine and Nanobiotechnology, Volume 15, Issue 1, January/February 2023., 2023
Various biosensing principles may serve for the detection and characterisation of extracellular vesicles. Herein, the key platform are systematically reviewed, with a focus on the most recent and fundamental developments. Abstract Research into extracellular vesicles (EVs) has grown significantly over the last few decades with EVs being widely regarded
Jugal Suthar, Marissa Taub, Randy P. Carney, Gareth R. Williams, Stefan Guldin   +4 more
wiley   +1 more source

Fully Automatic Deep Learning Framework for Pancreatic Ductal Adenocarcinoma Detection on Computed Tomography [PDF]

lves, N.; Schuurmans, M.;Litjens, G.; Bosma, J.S.; Hermans, J.;Huisman, H. Fully Automatic DeepLearning Framework for PancreaticDuctal Adenocarcinoma Detection onComputed Tomography.Cancers2022,14, 376, 2021
Early detection improves prognosis in pancreatic ductal adenocarcinoma (PDAC) but is challenging as lesions are often small and poorly defined on contrast-enhanced computed tomography scans (CE-CT). Deep learning can facilitate PDAC diagnosis, however current models still fail to identify small (<2cm) lesions.
arxiv  

PET/CT incidental detection of second tumor in patients investigated for pancreatic neoplasms [PDF]

, 2018
Positron Emission Tomography/computed tomography (PET/CT) is an imaging technique which has a role in the detection and staging malignancies (both in first diagnosis and follow-up).
Bissoli, Sergio, Fantin, Alberto, Moletta, Lucia, Passuello, Nicola, Sperti, Cosimo, Valmasoni, Michele   +5 more
core   +2 more sources