Results 71 to 80 of about 387,731 (304)

GlycoChat Uncovers Glycan–Lectin Circuits in the Tumor Microenvironment of Pancreatic Cancer

Advanced Science, EarlyView.
Aberrant glycosylation drives cancer progression, yet its role in the tumor microenvironment remains unclear. We developed GlycoChat to map glycan–lectin circuits at single‐cell resolution. We discovered that cancer cells induce immunosuppressive macrophage differentiation and impair phagocytosis through interactions with CLEC10A and SIGLEC3 ...
Dinh Xuan Tuan Anh, Sunanda Keisham, Arun Burramsetty, Lalhaba Oinam, Koichiro Kumano, Akihiro Kuno, Osamu Shimomura, Tatsuya Oda, Hiroaki Tateno   +8 more
wiley   +1 more source

Molecular analysis of appendiceal mucinous cystadenoma and rectal adenocarcinoma in a patient with urothelial carcinoma: a case report [PDF]

, 2013
Introduction: In this report, we present the case of a patient affected by appendiceal cystadenoma, a colorectal adenocarcinoma, and a concomitant bladder carcinoma, as well as the results of the molecular study of the most relevant mutational pathways ...
Colombino, Maria, Cossu, Antonio, Paliogiannis, Panagiotis, Palmieri, Giuseppe, Pulighe, Fabio, Scognamillo, Fabrizio, Trignano, Mario   +6 more
core   +1 more source

Gene signature driving invasive mucinous adenocarcinoma of the lung

EMBO Molecular Medicine, 2017
Though invasive mucinous adenocarcinoma of the lung (IMA) is pathologically distinctive, the molecular mechanism driving IMA is not well understood, which hampers efforts to identify therapeutic targets.
M. Guo, K. Tomoshige, M. Meister, T. Muley, T. Fukazawa, T. Tsuchiya, Rebekah A. Karns, A. Warth, I. Fink-Baldauf, T. Nagayasu, Y. Naomoto, Yan Xu, M. Mall, Yutaka Maeda   +13 more
semanticscholar   +1 more source

Logic‐Gated HSV‐TK/GCV Suicide Gene Circuit for Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
The BRAS comprises two modular genetic components driven by distinct tumor‐specific promoters and a failsafe layer with the NOT gate. This multi‐input logic gate circuit enables precise, specific expression of HSV‐TK in breast cancer cells with hardly expression in normal cell and effectively inhibits tumor growth in a triple‐negative breast cancer ...
Shasha Tang, Yuan Fang, Lingli Jin, Dongyang Liu, Yicheng Liu, Ruijia Zheng, Liyun Yong, Xin Wu, Longliang Qiao, Meiyan Wang, Fengfeng Cai   +10 more
wiley   +1 more source

A prognostic model of patients with ovarian mucinous adenocarcinoma: a population-based analysis

Journal of Ovarian Research, 2022
Background Ovarian mucinous carcinoma is a disease that requires unique treatment. But for a long time, guidelines for ovarian serous carcinoma have been used for the treatment of ovarian mucinous carcinoma.
Li Yang, Jinfen Yu, Shuang Zhang, Yisi Shan, Yajun Li, Liugang Xu, Jinhu Zhang, Jianya Zhang   +7 more
doaj   +1 more source

Data mining of gene arrays for biomarkers of survival in ovarian cancer [PDF]

, 2015
The expected five-year survival rate from a stage III ovarian cancer diagnosis is a mere 22%; this applies to the 7000 new cases diagnosed yearly in the UK.
Ball, GR, Boocock, DJ, Coveney, C, Deen, S, Rees, RC   +4 more
core   +2 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Giant mucinous adenocarcinoma of the appendix: a case report

Journal of Medical Case Reports, 2017
Background Appendiceal mucinous adenocarcinoma is an extremely rare disease in clinical practice. Here, we report a case of unprecedented size that occupied the entire abdomen of a man.
Sheng-Chun Dang, Ming-Ming Sun, Lu-Lu Liu, Abdul Malik, Jian-Xin Zhang, Yi-Yi Fan, Song Zou, Lei Cui, Jian-Guo Qu, Ji-Xiang Chen   +9 more
doaj   +1 more source

Incidence of lymph node metastases in clinical early-stage mucinous and seromucinous ovarian carcinoma: a retrospective cohort study [PDF]

, 2017
Objective: The use of lymph node sampling during staging procedures in clinical early-stage mucinous ovarian carcinoma (MOC) is an ongoing matter of debate. Furthermore, the incidence of lymph node metastases (LNM) in MOC in relation to tumour grade (G)
Buist, M.R., Coffelt, S.B., Kenter, G.G., Lok, C.A.R., van Baal, J.O.A.M., Van de Vijver, K.K., van der Noort, V., van Driel, W.J.   +7 more
core   +2 more sources

Effect of invasive mucinous adenocarcinoma on lung cancer-specific survival after surgical resection: a population-based study.

Journal of Thoracic Disease, 2018
Background In 2015, the World Health Organization (WHO) announced a new classification of lung tumors. Mucinous bronchioloalveolar adenocarcinomas were reclassified as invasive mucinous adenocarcinomas (IMAs).
S. Moon, S. Choi, M. Moon
semanticscholar   +1 more source