Results 61 to 70 of about 8,087 (209)

Droplet Digital CRISPR for Nucleic Acid Detection

Advanced Science, EarlyView.
This review outlines recent advances in droplet digital CRISPR technology for nucleic acid detection, combining CRISPR specificity with droplet digital‐based absolute quantification. It summarizes core principles, amplification‐assisted and amplification‐free strategies, and representative DNA and RNA biomarker applications.
Yang Zhang, Roy S. K. Walker, Anwar Sunna, Tracie J. Barber, Ming Li   +4 more
wiley   +1 more source

Efficient Preservation of Perishable Fruits by Erasable Metal‐Organic Frameworks

Advanced Science, EarlyView.
This study presents an erasable Pickering emulsion‐based coating stabilized by metal‐organic frameworks. This washable coating significantly extends fruit shelf life by scavenging ethylene and inhibiting foodborne pathogens, offering a sustainable solution for postharvest.
Liying Yang, Jia Kong, Haoran Bai, Xiaojie Wu, Douxin Xiao, Ming Du, Peng Yang, Alideertu Dong   +7 more
wiley   +1 more source

Xanthatin Targets CISD1 to Drive Ferroptosis and Mitophagy as a Dual Anticancer Strategy in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer has a poor prognosis. Xanthatin directly targets and degrades CISD1, triggering ferroptosis through iron dysregulation. The concurrently activated mitophagy synergistically amplifies ferroptotic cell death. Xanthatin also demonstrates potent in vivo anti‐tumor efficacy with minimal toxicity, highlighting its therapeutic ...
Qinwen Liu, Haojie Chen, Xiang Li, Jingxin Liu, Yiwen Li, Zhenyi Shi, Shenshen Guo, Qingfeng Du, Aiping Lu, Daogang Guan   +9 more
wiley   +1 more source

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai, Guihong Pan, Xixi Feng, Jun Zhang, Yunxia Li, Shanmeizi Zhao, Zhenming Lin, Yun Feng, Wei Bao, Hongyan Yang, Chengmei Xie, Chen Huang, Jun Wang   +12 more
wiley   +1 more source

ITALIAN CANCER FIGURES - REPORT 2015: The burden of rare cancers in Italy = I TUMORI IN ITALIA - RAPPORTO 2015: I tumori rari in Italia [PDF]

, 2016
OBJECTIVES: This collaborative study, based on data collected by the network of Italian Cancer Registries (AIRTUM), describes the burden of rare cancers in Italy.
Adamo, Ms, Adorni, A, Alessi, D, Aletta, P, Amendola, V, Amodio, R, Amodio, Rosalba, Andreone, S, Angelin, T, Anghinoni, E, Annulli, Ml, Autelitano, M, Balducci, C, Baracco, M, Baracco, S, Barale, A, Barchielli, A, Battisti, W, Bella, F, Bella, Francesca, Bellatalla, C, Bellini, A, Belluardo, C, Benatti, P, Benedetto, G, Benfatto, L, Bernazza, E, Bianconi, F, Biavati, P, Bidoli, E, Birri, S, Bizzoco, S, Bizzoco, Sabrina, Bonini, A, Borciani, E, Bordini, M, Bovo, E, Bozzani, F, Braghiroli, B, Brosio, F, Brucculeri, Ma, Brunori, V, Bucalo, G, Bucchi, L, Bugliarello, E, Bulatko, A, Busco, S, Busco, Susanna, Busso, P, Buzzoni, C, Buzzoni, C., Buzzoni, Carlotta, Caiazzo, Al, Calabrese, A, Calabretta, L, Caldarella, A, Candela, G, Cannone, G, Canu, L, Caparelli, M, Cappelletti, M, Caprara, L, Carletti, N, Caroli, S, Cascio, Ma, Cascone, G, Casella, C, Casella, C, Cassetti, Tiziana, Castaing, M, Castaing, Marine, Cavalieri d'Oro, L, Cavallo, R, Cecconami, L, Celesia, Mv, Cena, T, Cercato, Mc, Cesaraccio, R, Chiesa, R, Cirilli, C, Cirilli, Claudia, Cocchioni, M, Codazzi, T, Cogno, R, Colamartini, A, Colavolpe, Af, Cometti, I, Contiero, P, Contrino, Ml, Corbinelli, A, Cordaro, C, Corti, M, Costa, A, Costarelli, D, Coviello, V, Crapanzano, G, Crocetti, Emanuele, Cuccaro, F, Curatella, S, Cusimano, R, Cusimano, Rosanna, D'Alessandro, A, D'Alò, D, Dal Cin, A, Dal Maso, L, Dal Maso, Luigino, Davini, C, De Angelis, Roberta, De Dottori, M, De Maria, V, De Santis, E, De Valiere, E, Dei Tos, Ap, Demurtas, G, Devigili, E, Di Dia, Pp, Di Felice, E, di Grazia, L, Di Gregorio, C, Di Norcia, R, Di Prima, A, Dinaro, Y, Distefano, R, Doa, N, Domati, F, Donini, M, Fabiano, S, Facchinelli, G, Faccini, F, Falcini, F, Falk, M, Fanetti, Ac, Fattoruso, S, Fedele, M, Ferrari, F, Ferretti, S, Fidelbo, M, Filiberti, Ra, Filipazzi, L, Fiore, Ar, Forgiarini, O, Frasca, G, Frassoldi, E, Fusco, M, Fusco, M, Fusco, Mario, Gabbi, C, Gada, D, Garrone, E, Gatta, Gemma, Gatti, L, Gennaro, V, Gennaro, Valerio, Gentilini, Ma, Gerevini, C, Germinetti, F, Ghilardi, S, Ghisleni, S, Giacomin, A, Giacomin, Adriano, Giavazzi, L, Gilardi, F, Giorgetti, S, Giorgi Rossi, Paolo, Giubelli, C, Giuliani, O, Giurdanella, Mc, Gola, G, Goldoni, Ca, Goldoni, Ca, Golizia, Mg, Grandi, L, Greco, A, Guarda, L, Guttadauro, A, Guzzinati, S, Iannelli, A, Ieni, A, Intrieri, T, Kaleci, S, Lando, C, Lavecchia, Am, Lazzarato, F, Le Rose, L, Leone, A, Leone, R, Lombardo, C, Lonati, F, Lucchi, S, Macci, L, Macerata, V, Madeddu, A, Maffei, S, Maghini, A, Magnani, C, Magnani, G, Magoni, M, Mallone, Sandra, Mancini, S, Mancuso, P, Mangone, L, Mangone, L, Mangone, Lucia, Manneschi, G, Mannino, R, Mannino, S, Mannino, Salvatore, Marani, E, Mariani, F, Martorana, C, Marzola, L, Maspero, S, Maule, M, Mazzei, A, Mazzoleni, G, Mazzucco, G, Melcarne, A, Merletti, F, Merlo, E, Michiara, M, Migliari, E, Minerba, S, Minicuzzi, A, Mizzi, M, Monetti, D, Morana, G, Moroni, E, Mosso, Ml, Muni, A, Mura, F, Natali, M, Negrino, L, Nemcova, L, Nicita, C, Nocera, V, Paderni, F, Pala, F, Palumbo, M, Panciroli, E, Panico, M, Pannozzo, F, Pascucci, C, Pasolini, A, Pastore, G, Patriarca, S, Pedroni, M, Perrotta, C, Pesce, P, Petrinelli, Am, Petrucci, C, Pezzarossi, A, Pezzuto, L, Piccinni, L, Pierannunzio, Daniela, Piffer, S, Pinon, M, Pinto, A, Pintori, N, Pirino, D, Pironi, V, Ponz de Leon, M, Prandi, R, Prazzoli, R, Puleio, M, Puppo, A, Quarta, F, Quattrocchi, M, Raho, Am, Ramazzotti, V, Rashid, I, Ravaioli, A, Ravazzolo, B, Ravegnani, M, Reggiani-Bonetti, L, Ricci, P, Rizzello, R, Rognoni, M, Rollo, Pc, Romanelli, A, Roncaglia, F, Roncucci, L, Rosano, A, Rossi, F, Rossi, G, Rossi, M, Rossi, Silvia, Rossini, S, Rosso, S, Rudisi, G, Ruggeri, Mg, Russo, Ag, Ruzza, Mr, Sacchettini, C, Sacchetto, L, Sacco, G, Sacerdote, C, Sala, O, Salvi, O, Sampietro, G, Santucci, C, Scheibel, M, Sciacca, S, Sciacchitano, C, Sciacchitano, S, Scuderi, T, Sechi, O, Seghini, P, Senatore, G, Sensi, F, Serraino, D, Sgargi, P, Sini, Gm, Sobrato, I, Solimene, C, Spagnoli, G, Spano, F, Spata, E, Sperduti, I, Spinosa, S, Staiti, R, Stocco, C, Storchi, C, Stracci, F, Sunseri, R, Susini, N, Sutera Sardo, A, Tagliabue, G, Tamburo, L, Tamburrino, S, Taranto, V, Tavilla, Andrea, Terracini, B, Tisano, F, Tittarelli, A, Tognazzo, S, Tognazzo, Sandro, Torrisi, A, Torrisi, A, Traina, A, Trama, Annalisa, Trapani, C, Tschugguel, B, Tumino, R, Tumino, Rosario, Usala, M, Vacirca, S, Valente, N, Valerio, O, Valla, K, Varvarà, M, Vasquez, E, Vassante, B, Vattiato, R, Vercellino, Pc, Vicentini, M, Vicentini, Massimo, Villa, M, Visoli, C, Vitale, F, Vitale, Maria Francesca, Vitale, Mf, Vitali, B, Vitali, Me, Vitarelli, S, Vittadello, F, Zanchi, A, Zanetti, R, Zani, G, Zanier, L, Zappa, M, Zarcone, M, Ziino, Ac, Zorzi, M, Zucchetto, A, Zucchi, A   +374 more
core   +1 more source

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

Advanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su, Guang Li, Yudong Guan, Qi Tian, Youzhi Qi, Yanqiu Zhang, Wenqian Wei, Xinxin Duan, Jiaxin Rui, Hongyan Zhu, Zengping Lin, Changchuan Xie, Zheni Xu, Yaying Wu, Xin Peng, Zhenjie Wang, Kun Chen, Xiaoyan Xin, Bing Zhang   +18 more
wiley   +1 more source

Cholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation

Advanced Science, EarlyView.
Cholesterol is revealed as a multitasking fuel for lung adenocarcinoma brain metastasis: it locks EGFR at the membrane to sustain AKT/NF‐κB–driven glycolysis and EMT, loosens the blood–brain barrier by promoting Claudin‐5 loss, and rewires microglia through IL‐4R lipid‐raft–JAK1/STAT6 signaling.
Ying Chen, Xiaoteng Cui, Xinyi Shi, Xu Yang, Yujing Cao, Haolin LI, Qi Zhan, Qixue Wang, Ang Li, Qihong Cheng, Yunfei Wang, Junhu Zhou, MingJie Wang, Chunsheng Kang, Xiaomin Liu   +14 more
wiley   +1 more source

Valorization of the peel and husk of guaraná (Paullinia cupana): oil extraction, chemical composition, cytotoxicity, and antitumor potential

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract Guaraná (Paullinia cupana) is a fruit native to the Amazon region. Due to its widespread use, primarily in beverages, its production has grown over the years. The seed is the only commercially valuable part of the fruit so the guaraná production chain generates byproducts, including peel, husk, and spent seed.
Leiliane do Socorro Sodré de Souza, Guilherme Teixeira de Azevedo, Eduardo Leonarski, Giovana Lima de Souza, Rafael Lopes e Oliveira, Sérgio Duvoisin Junior, Karina Cesca, Débora de Oliveira, Anderson Mathias Pereira, Ariane Mendonça Kluczkovski   +9 more
wiley   +1 more source

Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks

British Journal of Clinical Pharmacology, EarlyView.
The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou, Georgia Valsami, Georgios Ismailos   +2 more
wiley   +1 more source

Poliposis familiar hereditaria y síndrome de Gardner: aportación de la exploración odontoestomatológica a su diagnóstico y descripción de un caso [PDF]

, 2005
La poliposis adenomatosa familiar (PAF) y su variante fenotípica, el síndrome de Gardner, constituyen una infrecuente patología hereditaria autosómica dominante.
Blanco, Ignacio, Chimenos Küstner, Eduardo, Finestres, Fernando, Pacual, Montserrat   +3 more
core   +1 more source