Results 221 to 230 of about 1,279,856 (386)

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

Dabrafenib plus trametinib in an elderly patient with BRAF V600E-mutant advanced pancreatic adenocarcinoma: A case report. [PDF]

Front Oncol
Liu L, Zhu X, Guo Y, Tang M, Zhou W, Chen B.   +5 more
europepmc   +1 more source

Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses

Cell, 2017
Yonit Lavin, Soma Kobayashi, A. Leader, E. Amir, Naama Elefant, Camille Bigenwald, R. Remark, Robert Sweeney, C. D. Becker, Jacob H. Levine, K. Meinhof, A. Chow, Seunghee Kim-Shulze, A. Wolf, Chiara Medaglia, Hanjie Li, J. Rytlewski, R. Emerson, Alexander Solovyov, B. Greenbaum, C. Sanders, M. Vignali, M. Beasley, R. Flores, S. Gnjatic, D. Pe’er, Adeeb H. Rahman, I. Amit, M. Merad   +28 more
semanticscholar   +1 more source

Stimuli‐Responsive CuFeTe2 Nanosheets for Amplified Cuproptosis/Ferroptosis in Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Dual‐stimuli‐responsive CuFeTe2 nanosheets (CFT) induce cuproptosis/ferroptosis via TME‐responsive Fe2⁺/Cu2⁺ release and NIR‐II photothermal effects, amplifying ROS and depleting HSP70/ATP to trigger ICD and immune activation, while ensuring biocompatible renal clearance for TNBC therapy.
Molin Liu, Jian Zheng, Mengqi Yu, Qirui Wang, Yi Yuan, Nannan Shao, Xiaoliang Yang, Tianxi Shen, Li Wang, Aiyun Li, Rui Liu, Jimin Cao, Xi Liu, Fangfang Cao, Yanlin Feng   +14 more
wiley   +1 more source

Cribriform Adenocarcinoma of the Nasal Cavity Harboring a Novel <i>NAP1L1::PRKD1</i> Fusion, Expanding the Molecular Landscape of Minor Salivary Gland Tumors. [PDF]

Case Rep Pathol
Duarte EM, Germani R, Nicholson C, Baruch A, Shattuck T.   +4 more
europepmc   +1 more source

Interferon‐Driven Biomarkers and Synergistic Therapy for PRMT5 Inhibition in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer exhibits variable sensitivity to PRMT5 inhibition. Basal interferon signaling is identified as a key biomarker of response. PARP inhibition with olaparib induces IFN signaling, sensitizing resistant TNBC cells to PRMT5 inhibitors.
Ziwen Zhang, Sheyu Zhang, Lu Guo, Yichun Pan, Juan Huang, Yishuai Ji, Jiaqi Tao, Yong Wei, Xiaojia Wang, Qin Wu   +9 more
wiley   +1 more source

SATB2 is Rarely Expressed in Endometrial or Endocervical Carcinoma. [PDF]

APMIS
Amaamri-Seebach T, Mobarki M, Musawi S, Péoc'h M, Karpathiou G.   +4 more
europepmc   +1 more source

tRNA‐Derived Fragment tRF‐22 Promotes Immunosuppression by Inhibiting HnRNPAB Ubiquitination in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
tRF‐22 fosters an immunosuppressive and pro‐oncogenic tumor microenvironment in ESCC by stabilizing hnRNPAB against TRIM25‐mediated ubiquitination and enhancing TGFβ2 expression, which increases PMN‐MDSCs infiltration and suppresses CD8+ T cells. Targeting tRF‐22 or blocking TGFβ signalling improves anti‐PD1 response, offering a promising therapeutic ...
Ling Pan, Xin Qin, Li Gong, Haining Liu, Bo Cheng, Jing Wang, Yajie Hu, Lingxing Zeng, Yiping Wang, Qingxu Song, Yufeng Cheng   +10 more
wiley   +1 more source

Colorectal clear cell carcinoma: a literature review. [PDF]

J Med Case Rep
Salehi M, Rehman S, Jafari A, Yazdani MJ, Hashim S, Jafari HR.   +5 more
europepmc   +1 more source

Overexpression of geranylgeranyl diphosphate synthase contributes to tumour metastasis and correlates with poor prognosis of lung adenocarcinoma

, 2018
Xiaoxia Wang, Wujian Xu, Ping Zhan, Tianxiang Xu, Jiajia Jin, Yingying Miu, Zejun Zhou, Qingqing Zhu, Bing Wan, Guangmin Xi, Ye Liang, Yafang Liu, Jianwei Gao, Huijuan Li, Tangfeng Lv, Yong Song   +15 more
openalex   +1 more source