Results 71 to 80 of about 512,435 (267)

First Line Androgen Deprivation Therapy vs. Chemotherapy for Patients With Androgen Receptor Positive Recurrent or Metastatic Salivary Gland Carcinoma—A Retrospective Study

Frontiers in Oncology, 2019
Objectives: There is a lack of effective therapy for recurrent or metastatic salivary gland carcinoma. Androgen deprivation therapy has demonstrated efficacy in cases of salivary duct carcinoma (SDC) and high-grade adenocarcinoma not otherwise specified (
Paul V. Viscuse, Katharine A. Price, Joaquin J. Garcia, David J. Schembri-Wismayer, Ashish V. Chintakuntlawar   +4 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Correlation of prostate-specific antigen levels with Gleason score and tumor percentage on prostate needle biopsy in prostate cancer

Journal of Dr. NTR University of Health Sciences
Introduction: Prostate-specific antigen (PSA) plays an important role in the detection of prostate cancer. Although it has high sensitivity and low specificity, it is still used clinically. A biopsy is recommended if any abnormality is detected in PSA or
Priyanka Singh, Rajpal Singh Punia, Harshi Dhingra, Vidur Bhalla   +3 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Adenocarcinoma of the lung mimicking interstitial lung disease

Gülhane Tıp Dergisi
Atypical radiologic and clinical patterns may be observed within subgroups of lung adenocarcinoma. A 74-year-old man with progressive dyspnea and productive cough unresponsive to antibiotherapy showed bilateral interstitial changes in the lung parenchyma
Sümeyye Kodalak Cengiz, Nesrin Kıral, Tamer Baysal, Gonca Gül Geçmen   +3 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Yolk Sac Tumor in Ascitic Fluid – Cytodiagnosis of a Rare Case

Archives of Medicine and Health Sciences
Yolk sac tumor (YST) is a germ cell tumor of gonads presenting in children and young adults. It is rare to find metastasis of the YST in effusion fluid.
Meesa Mehraj, Durre Aden, Sabina Khan, Nehal Ahmad, Sujata Jetley   +4 more
doaj   +1 more source

Coexistence of adenocarcinoma colon with pseudomembraneous colitis

Journal of Digestive Endoscopy, 2013
We report a 62 year old man who had coexistence of pseudomembraneous colitis and adenocarcinoma sigmoid colon in the absence of any antibiotic therapy. This is the first report of coexistence of both these conditions in the same patient.
Sanjay Kumar Somani, Shalini Kapoor, Anju Shukla   +2 more
doaj   +1 more source

Intraoesophageal Adenocarcinoma [PDF]

Gut, 1960
A study of 87 cases of carcinoma involving the gastro-oesophageal region included seven cases of adenocarcinoma confined to the anatomical limits of the oesophagus. Six of these intraoesophageal adenocarcinomas appear to have arisen in “oesophagi lined by columnar epithelium”.
openaire   +2 more sources