Results 51 to 60 of about 672,479 (309)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Clinicopathological Profile and Management of Appendiceal Neoplasm: An Observational Study

Journal of Nepal Medical Association
Introduction: Appendiceal neoplasms are rare and frequently diagnosed incidentally during histopathological examination of appendectomy specimens. Recent data suggest that their incidence is increasing worldwide.
Abhishek Bhattarai, Prasan Bir Singh Kansakar, Laligen Awale, Bikal Ghimire, Homendra Kumar Sah   +4 more
doaj   +1 more source

Epigenetics: DNA Methylation Analysis in Esophageal Adenocarcinoma

, 2018
The aberrant DNA methylation has been noted to occur at promoter of tumor suppressor, cell adhesion, DNA repair, and other growth regulating genes during the progression of nonneoplastic esophageal mucosa to Barrett esophagus to esophageal adenocarcinoma.
Johnny C. Tang, Islam, F, Lam, AK, Farhadul Islam, Tang, JC, Vinod Gopalan, Gopalan, V, Alfred K. Lam   +7 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Solitary Metastasis of Pulmonary Adenocarcinoma in Restricted Thyroid Gland Nodule

Bezmiâlem Science, 2018
Metastatic tumors of thyroid are rare and constitute 1.2% of all thyroid malignancies. Metastasis to thyroid gland from head and neck region occurs usually via direct spread.
Esra PAŞAOĞLU, Feray GÜNVER, Zuhal GÜCİN   +2 more
doaj   +1 more source

Pulmonary adenocarcinoma with mucin production and possible subtyping based on driver mutations and transcription factors [PDF]

, 2019
The current WHO classification of lung cancer cannot appropriately characterize adenocarcinoma with mucin production. No suitable entity or typical adenocarcinoma with mucin has been established, and only two variants exist: invasive mucinous ...
Ishikawa, Yuichi, Muto, Mariko, Okumura, Sakae, Kitagawa, Masanobu, Ninomiya, Hironori, Inamura, Kentaro   +5 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Tumor de colon. Reporte de dos casos y revisión de la literatura

Medisur, 2013
El cáncer de colon es actualmente un importante problema de salud pública en los países desarrollados. Es el cuarto cáncer más frecuente en el mundo, y también en Cuba.
Yarisdey Corrales Hernández
doaj  

ADENOCARCINOMA OF RECTUM [PDF]

Annals of Surgery, 1909
n ...
openaire   +2 more sources

Introduction: Esophageal Adenocarcinoma: Updates of Current Status

, 2018
Esophageal and esophagogastric adenocarcinoma is highly prevalent in the Western populations and is a major cause of cancer-related morbidity and mortality worldwide. The incidence of esophageal adenocarcinoma is rapidly rising in the Western populations.
Lam, AK, Lam, Alfred, Alfred K. Lam
core   +1 more source