Results 51 to 60 of about 1,187,996 (336)

Pancreatic Adenocarcinoma, Version 1.2019.

The Journal of the National Comprehensive Cancer Network, 2019
The NCCN Guidelines for Pancreatic Adenocarcinoma discuss the diagnosis and management of adenocarcinomas of the exocrine pancreas and are intended to assist with clinical decision-making.
Margaret Tempero, M. Malafa, E. G. Chiorean, B. Czito, C. Scaife, A. Narang, C. Fountzilas, B. Wolpin, M. Al-Hawary, H. Asbun, Stephen W. Behrman, Al B. Benson, E. Binder, D. Cardin, Charles Cha, V. Chung, M. Dillhoff, E. Dotan, C. Ferrone, G. Fisher, J. Hardacre, William Hawkins, Andrew H. Ko, N. Loconte, Andrew M. Lowy, C. Moravek, E. Nakakura, Eileen M. O’Reilly, Jorge V. Obando, S. Reddy, S. Thayer, Robert A. Wolff, J. Burns, Griselda Zuccarino-Catania   +33 more
semanticscholar   +1 more source

Genomic characterization of human brain metastases identifies drivers of metastatic lung adenocarcinoma

Nature Genetics, 2020
Brain metastases from lung adenocarcinoma (BM-LUAD) frequently cause patient mortality. To identify genomic alterations that promote brain metastases, we performed whole-exome sequencing of 73 BM-LUAD cases.
D. Shih, D. Shih, Naema Nayyar, Ivanna V. Bihun, Ivanna V. Bihun, I. Dagogo-Jack, C. Gill, C. Gill, Elisa Aquilanti, Elisa Aquilanti, Mia S Bertalan, Alexander Kaplan, M. D’Andrea, U. Chukwueke, F. M. Ippen, Christopher A. Alvarez-Breckenridge, Nicholas D. Camarda, Matthew Lastrapes, D. McCabe, D. McCabe, Benjamin M Kuter, B. Kaufman, B. Kaufman, M. Strickland, J. Martinez-Gutierrez, J. Martinez-Gutierrez, Deepika Nagabhushan, Magali De Sauvage, Michael D. White, Brandyn Castro, Kaitlin Hoang, Andrew Kaneb, Emily Batchelor, S. Paek, S. H. Park, M. Martinez-Lage, A. Berghoff, Parker Merrill, E. Gerstner, T. Batchelor, M. Frosch, Ryan P. Frazier, D. Borger, A. Iafrate, B. Johnson, S. Santagata, S. Santagata, M. Preusser, D. Cahill, S. Carter, P. Brastianos, P. Brastianos   +51 more
semanticscholar   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Comparing 2D and 3D Feature Extraction Methods for Lung Adenocarcinoma Prediction Using CT Scans: A Cross-Cohort Study

Applied Sciences
Lung cancer stands as the most prevalent and deadliest type of cancer, with adenocarcinoma being the most common subtype. Computed Tomography (CT) is widely used for detecting tumours and their phenotype characteristics, for an early and accurate ...
Margarida Gouveia, Tânia Mendes, Eduardo M. Rodrigues, Hélder P. Oliveira, Tania Pereira   +4 more
doaj   +1 more source

A rare clinical case of a patient with mixed neuroendocrine-non-neuroendocrine neoplasms of the ampulla of vater

Сибирский онкологический журнал, 2023
Background. Neuroendocrine tumors are rare neoplasias accounting for 1 % of all digestive malignancies. In 2010, mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) were classified by the World Health Organization This type of tumor is extremely ...
E. S. Drozdov, M. Yu. Grishchenko, V. I. Kharitonkin, N. I. Lyan, O. Yu. Borodin, E. A. Fesik, A. G. Korotkevich   +6 more
doaj   +1 more source

Endocervical glandular neoplasia associated with lobular endocervical glandular hyperplasia is HPV-independent and correlates with carbonic anhydrase-IX expression: a Gynaecological Oncology Group Study. [PDF]

, 2013
BackgroundLobular endocervical glandular hyperplasia (LEGH) is a rare lesion of the uterine cervix. It has been proposed that LEGH may represent a precursor lesion to a group of mucinous adenocarcinoma with gastric phenotype (GA) that is independent of ...
Carter, R, Darcy, KM, Hatae, M, Kauderer, J, Liao, SY, Nagao, S, Rodgers, WH, Stanbridge, EJ, Susumu, N, Walker, JL   +9 more
core   +1 more source

Pathologist-level classification of histologic patterns on resected lung adenocarcinoma slides with deep neural networks [PDF]

Scientific Reports, 2019
Classification of histologic patterns in lung adenocarcinoma is critical for determining tumor grade and treatment for patients. However, this task is often challenging due to the heterogeneous nature of lung adenocarcinoma and the subjective criteria ...
Jason Wei, L. Tafe, Yevgeniy A. Linnik, L. Vaickus, Naofumi Tomita, S. Hassanpour   +5 more
semanticscholar   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Pancreatic Ductal Adenocarcinoma: Epidemiology and Risk Factors

Diagnostics, 2021
The number of new cases of pancreatic ductal adenocarcinoma is increasing with a cumulative total of 495,773 cases worldwide, making it the fourteenth most common malignancy.
J. Ushio, A. Kanno, Eriko Ikeda, Kozue Ando, Hiroki Nagai, Tetsurou Miwata, Yuki Kawasaki, Y. Tada, Kensuke Yokoyama, Norikatsu Numao, K. Tamada, A. Lefor, H. Yamamoto   +12 more
semanticscholar   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source