Results 71 to 80 of about 329,845 (308)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Predilection of contralateral upper lung metastasis in upper lobe lung adenocarcinoma patients [PDF]
, 2017 Background: Lung cancer with lung to lung metastasis is common. The objective of this study was to investigate the association among the distribution of contralateral lung metastases versus primary lung tumor location, clinical characteristics, and ...
Huang, Yen-Hsiang;Hsu, Kuo-Hsuan;Tseng, Jeng-Sen;Chen, Kun-Chieh;Su, Kang-Yi;Chen, Hsuan-Yu;Chang, Chi-Sheng;Chen, Jeremy J. W.;Yu, Sung-Liang;Chen, Huei-Wen;Yang, Tsung-Ying;Chang, Gee-Chen +1 more
core +1 more source
Respiratory Medicine Case Reports, 2019 Primary lung adenocarcinoma, diffuse pneumonic type, can mimic the clinical presentation of an infectious or inflammatory lung disease, which can represent a diagnostic challenge.
Asil Daoud +3 more
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Molecular Therapy: Nucleic Acids, 2019 Long non-coding RNAs (lncRNAs) have emerged as key regulators of cellular progress in lung adenocarcinoma. In this study, to identify cancer-related lncRNAs and genes, we screened for those lncRNAs that were differentially expressed in lung ...
Shu-Feng Xu +10 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
SNP rs10248565 in HDAC9 as a novel genomic aberration biomarker of lung adenocarcinoma in non-smoking women [PDF]
, 2017 Background: Numerous efforts have been made to elucidate the etiology and improve the treatment of lung cancer, but the overall five-year survival rate is still only 15%.
李章銘;賴亮全 +1 more
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Expression of ASPM in Lung Adenocarcinoma and Its Relationship with Development and Prognosis
Chinese Journal of Lung Cancer, 2020 Background and objective Previous studies have shown that ASPM is a tumorigenesis associated protein, mutations in ASPM can lead to MCPH. This study mainly explores the relationship between the ASPM expression of lung adenocarcinoma and the development ...
Junjie WANG, Zhenyu HE, Renhui DUAN
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Clinical, morphological and molecular characterization of cancer phenotypes associated with chronic obstructive pulmonary disease (COPD): new prospective of target therapies [PDF]
, 2013 BACKGROUND Chronic obstructive pulmonary disease (COPD) and lung cancer are two catastrophic diseases, representing leading causes of morbidity and mortality worldwide.
Schiavon, Marco
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