Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer. [PDF]
, 2019 Although targeted therapies often elicit profound initial patient responses, these effects are transient due to residual disease leading to acquired resistance.
A Hübner +66 more
core +1 more source
Lung adenocarcinoma originates from retrovirus infection of proliferating type 2 pneumocytes during pulmonary post-natal development or tissue repair [PDF]
, 2011 Jaagsiekte sheep retrovirus (JSRV) is a unique oncogenic virus with distinctive biological properties. JSRV is the only virus causing a naturally occurring lung cancer (ovine pulmonary adenocarcinoma, OPA) and possessing a major structural protein that ...
A Giangreco +93 more
core +6 more sources
Fibroblast growth factor receptor signaling in hereditary and neoplastic disease: biologic and clinical implications. [PDF]
, 2015 Fibroblast growth factors (FGFs) and their receptors (FGFRs) are transmembrane growth factor receptors with wide tissue distribution. FGF/FGFR signaling is involved in neoplastic behavior and also development, differentiation, growth, and survival.
Helsten, Teresa +2 more
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BRD7 Acts as a Tumor Suppressor Gene in Lung Adenocarcinoma. [PDF]
PLoS ONE, 2016 Lung cancer is one of the most malignant tumors and the leading cause of cancer-related deaths worldwide. Among lung cancers, 40% are diagnosed as adenocarcinoma. Bromodomain containing 7 (BRD7) is a member of bromodomain-containing protein family.
Yushun Gao, Bing Wang, Shugeng Gao
doaj +1 more source
Increasing incidence of adenocarcinoma of the lung [PDF]
Cancer, 1981 Review of the histology of 219 lung cancers initially diagnosed at Lutheran General Hospital, Park Ridge, Illinois, in 1963-1967 and 1974-1976, confirms the increasing incidence of adenocarcinoma. This is due to an increase of adenocarcinoma in men. In women, the incidence of adenocarcinoma was higher than squamous carcinoma in the earliest period (44%
J, Valaitis, S, Warren, D, Gamble
openaire +2 more sources
AGTR1 Inhibits the Progression of Lung Adenocarcinoma
Cancer Management and Research, 2021 Lecai Xiong,1 Yanhong Wei,2 Xiao Zhou,1 Peng Dai,1 Yi Cai,1 Xuefeng Zhou,1 Ming Xu,1 Jinping Zhao,1 Hexiao Tang1 1Department of Thoracic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, People’s Republic of China; 2Department of ...
Xiong L +8 more
doaj
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2012 Symptomatic gastro-intestinal metastasis in lung cancer is extremely rare and only a few case reports have been published. Here, we report a case with lung adenocarcinoma that presented with acute abdominal pain, nausea and vomiting due to duodenum ...
C. Hsing +7 more
semanticscholar +1 more source
Histogram-based models on non-thin section chest CT predict invasiveness of primary lung adenocarcinoma subsolid nodules. [PDF]
, 2019 109 pathologically proven subsolid nodules (SSN) were segmented by 2 readers on non-thin section chest CT with a lung nodule analysis software followed by extraction of CT attenuation histogram and geometric features.
Dmytriw, Adam A +7 more
core +2 more sources
EGFR Mutation Status in Uighur Lung Adenocarcinoma Patients
Chinese Journal of Lung Cancer, 2013 Background and objective Epidermal growth factor receptor (EGFR), a transmembrane protein, is a member of the tyrosine kinase family. Gefitinib, an EGFR tyrosine-kinase inhibitors, has shown a high response rate in the treatment of lung cancer in ...
Li SHAN +4 more
doaj +1 more source
Dual EGFR inhibition in combination with anti-VEGF treatment: a phase I clinical trial in non-small cell lung cancer. [PDF]
, 2013 BackgroundPreclinical data indicate EGFR signals through both kinase-dependent and independent pathways and that combining a small-molecule EGFR inhibitor, EGFR antibody, and/or anti-angiogenic agent is synergistic in animal models.MethodsWe conducted a ...
Bastida, Christel +11 more
core +2 more sources