Results 151 to 160 of about 17,976 (173)
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The adenomatous polyposis coli protein: in the limelight out at the edge
Trends in Cell Biology, 2001Truncation mutations in the adenomatous polyposis coli protein (APC) are responsible for familial and sporadic colonic tumours. APC is best known for its role in regulating beta-catenin, an important mediator of cell adhesion and a transcriptional activator. However, recent studies indicate that APC has additional roles in cytoskeletal regulation.
D, Dikovskaya +3 more
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Adenomatous polyposis coli, protein kinases, protein tyrosine phosphatase: The effect of sulindac
Journal of Surgical Oncology, 1995AbstractA putative explanation of the effect of sulindac on adenomatous colon and duodenal polyps from clinical observations and related in vitro experiments is presented. In cells with mutant APC genes, persistent high prostaglandin content of polyps leads to desensitization, downregulation of adenylate cyclase, uncoupling of cAMP synthesis from ...
W R, Waddell, R L, Miesfeld
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THE ADENOMATOUS POLYPOSIS COLI PROTEIN: The Achilles Heel of the Gut Epithelium
Annual Review of Cell and Developmental Biology, 2004▪ Abstract The Adenomatous Polyposis coli (APC) gene is mutated or lost in most colon cancers, and the APC protein has emerged as a multifunctional protein that is not only involved in the Wnt-regulated degradation of β-catenin, but also regulates cytoskeletal proteins and thus plays a role in cell migration, cell adhesion, and mitosis.
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Adenomatous polyposis coli protein regulates the cellular response to DNA replication stress
The International Journal of Biochemistry & Cell Biology, 2011The adenomatous polyposis coli (APC) tumor suppressor traffics between nucleus and cytoplasm to perform distinct functions. Here we identify a specific role for APC in the DNA replication stress response. The silencing of APC caused an accumulation of asynchronous cells in early S phase and delayed S phase progression in cells released from hydroxyurea-
Mariana G, Brocardo +2 more
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Biochemical and Biophysical Research Communications, 1995
The adenomatous polyposis coli (APC) gene is etiologically associated with familial adenomatous polyposis and gastrointestinal malignancies, but its cellular function and role in tumorigenesis are unclear. Recent reports indicate that wild-type, but not mutant, APC gene product (APC) is associated with and promotes the assembly of cytoskeletal ...
G, Bhattacharya, B M, Boman
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The adenomatous polyposis coli (APC) gene is etiologically associated with familial adenomatous polyposis and gastrointestinal malignancies, but its cellular function and role in tumorigenesis are unclear. Recent reports indicate that wild-type, but not mutant, APC gene product (APC) is associated with and promotes the assembly of cytoskeletal ...
G, Bhattacharya, B M, Boman
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2008
The adenomatous polyposis coli (APC) tumour suppressor gene is mutated in the majority of colon cancers. APC is a multi-domain protein whose distribution at different subcellular locations correlates with unique cellular processes. Our laboratory has focused on the link between APC subcellular location and function, and has characterized pathways for ...
Mariana, Brocardo, Beric R, Henderson
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The adenomatous polyposis coli (APC) tumour suppressor gene is mutated in the majority of colon cancers. APC is a multi-domain protein whose distribution at different subcellular locations correlates with unique cellular processes. Our laboratory has focused on the link between APC subcellular location and function, and has characterized pathways for ...
Mariana, Brocardo, Beric R, Henderson
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Regulated nuclear import of the adenomatous polyposis coli protein.
2012Mutation of the Adenomatous Polyposis Coli (APC) gene is an early step in the development of colorectal carcinomas. To provide clues for APC's role in tumor suppression, the subcellular distribution of APC was studied, and APC was found to localize to both the cytoplasm and the nucleus of normal human epithelial cells. The objectives of this study were
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Expressions of two adenomatous polyposis coli and E-cadherin proteins on human colorectal cancers
Virchows Archiv, 2003Mutations in the adenomatous polyposis coli (APC) gene contribute to the progression of colorectal tumorigenesis. Despite the importance, few studies regarding the localization of this protein on surgically resected human colorectal cancer specimens using immunohistochemistry have been reported so far because of the unavailability of the antibodies for
Koh, Furuta +8 more
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APC GENE-MUTATIONS IN FAMILIAL ADENOMATOUS POLYPOSIS-COLI IDENTIFIED AT THE DNA AND PROTEIN LEVEL
International Journal of Oncology, 1993Peripheral blood cell DNA of patients suffering from Familial Adenomatous Polyposis coli (FAP) were subjected to SSCP screening analyses. Here, we report on a patient, who was diagnosed at the age of 31 years suffering from a severe form of adenomatous polyposis coli.
C, Kraus +3 more
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2012
The Adenomatous Polyposis Coli (APC) tumor suppressor gene is responsible for an inherited predisposition to colon cancer through the development of multiple colorectal adenomas. Mutations in APC are also found in the majority of sporadic colorectal cancers, indicating that APC function is critical to maintenance of cell growth and differentiation in ...
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The Adenomatous Polyposis Coli (APC) tumor suppressor gene is responsible for an inherited predisposition to colon cancer through the development of multiple colorectal adenomas. Mutations in APC are also found in the majority of sporadic colorectal cancers, indicating that APC function is critical to maintenance of cell growth and differentiation in ...
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