Results 141 to 150 of about 17,976 (173)

Adenomatous Polyposis Coli Protein is Expressed in Alternate Stages of the Ameloblast Life Cycle

Journal of Dental Research, 1998
Mutations of the adenomatous polyposis coli gene protein (APC) are associated with familial polyposis and also sporadic colon adenomas, both preconditions to cancer formation. Some familial polyposis patients also develop Gardner's syndrome, a condition characterized by supernumerary teeth, mandibular osteomas, and other maladies.
Barbara Sorkin, Z Skobe
exaly   +3 more sources

The adenomatous polyposis coli tumor suppressor protein and microtubule dynamics

Current Colorectal Cancer Reports, 2007
Colorectal cancer is closely associated with mutation of the gene encoding the adenomatous polyposis coli (APC) tumor suppressor protein. A role has been defined for APC in the Wnt signaling pathway, in which it is responsible for mediating the degradation of the protein β-catenin.
Anke Brüning-Richardson, Morrison Ewan E   +1 more
exaly   +2 more sources

Aspirin augments the expression of Adenomatous Polyposis Coli protein by suppression of IKKβ

Biochemical and Biophysical Research Communications, 2014
Aspirin has been widely used as analgesic, antipyretic and anti-inflammatory medicine for long. In addition to these traditional effects, clinical studies suggest that aspirin can protect against cancer, but its mechanism has not been explored. To unveil it, we identified the proteins up- or down-regulated after incubation with aspirin by using ...
, Kaeko Kamei
exaly   +3 more sources

Localization of the adenomatous polyposis coli tumour suppressor protein in the mouse central nervous system

Neuroscience, 1998
The adenomatous polyposis coli gene is mutated in familial adenomatous polyposis and in sporadic colorectal tumours. The adenomatous polyposis coli gene product is a 300,000 mol. wt cytoplasmic protein that binds to at least three other proteins; beta-catenin, a cytoplasmic E-cadherin-associated protein; hDLG, a human homologue of the Drosophila discs ...
Akihiko Matsumine, Takao Senda, Satoshi Iino   +2 more
exaly   +3 more sources

Adenomatous Polyposis Coli (APC) Protein Expression in Primary and Metastatic Serous Ovarian Carcinoma

International Journal of Surgical Pathology, 2002
The aim of this study was to investigate protein expression of adenomatous polypois coli (APC) in primary and metastatic serous ovarian carcinoma. The expression of 3-catenin and E-cadherin was additionally analyzed. One hundred and thirteen priary (n=56) and metastatic (n=57) lesions were immunohistochemically stained for APC, E-cadherin, and f ...
Ben Davidson, Claes G Tropé
exaly   +3 more sources

Ca2+ regulates the subcellular localization of adenomatous polyposis coli tumor suppressor protein

Biochemical and Biophysical Research Communications, 2009
Microtubule (MT) plus-end tracking proteins (+TIPs) are involved in the regulation of MT plus-end dynamics and stabilization. It was reported previously that an increase in intracellular Ca(2+) concentration ([Ca(2+)](i)) induced by disruption of the plasma membrane stimulates rearrangement of MTs [T.
Tatsuru Togo
exaly   +3 more sources

Non-traditional roles for the Adenomatous Polyposis Coli (APC) tumor suppressor protein

Gene, 2005
The Adenomatous Polyposis Coli (APC) tumor suppressor is a multifunctional protein that is mutated in a majority of colon cancers. The role of APC as an antagonist of the Wnt signaling pathway is well known and it is widely accepted that inappropriate activation of this pathway through loss of APC function contributes to the progression of colon ...
Caroline A, Hanson, Jeffrey R, Miller
exaly   +3 more sources

The adenomatous polyposis coli protein 3o years on

2022
ABSTRACT Mutations in the gene encoding the Adenomatous polyposis coli protein (APC) were discovered as driver mutations in colorectal cancers almost 30 years ago. Since then, the importance of APC in normal tissue homeostasis has been confirmed in a plethora of other (model) organisms spanning a large evolutionary space.
James Abbott, Inke S. Näthke
openaire   +1 more source

Adenomatous polyposis coli proteins and cell adhesion

Current Opinion in Cell Biology, 2004
Adenomatous polyposis coli (APC) is an important tumour suppressor in the mammalian intestinal epithelium. It binds to beta-catenin and its role as a tumour suppressor depends predominantly on its ability to downregulate soluble beta-catenin, a key effector of the Wnt signalling pathway.
Mariann, Bienz, Fumihiko, Hamada
openaire   +2 more sources

A role for the Adenomatous Polyposis Coli protein in chromosome segregation

Nature Cell Biology, 2001
Mutations in the Adenomatous Polyposis Coli (APC) gene are responsible for familial colon cancer and also occur in the early stages of sporadic colon cancer. APC functions in the Wnt signalling pathway to regulate the degradation of beta-catenin (reviewed in refs 1-3).
Kaplan, Kenneth B., Burds, Aurora A., Swedlow, Jason R., Bekir, Songül S., Sorger, Peter K., Näthke, Inke S.   +5 more
openaire   +3 more sources