Results 121 to 130 of about 30,293 (217)

Impaired neurodevelopmental pathways in autism spectrum disorder: a review of signaling mechanisms and crosstalk. [PDF]

, 2019
BackgroundThe development of an autistic brain is a highly complex process as evident from the involvement of various genetic and non-genetic factors in the etiology of the autism spectrum disorder (ASD). Despite being a multifactorial neurodevelopmental
Gu, Ran, Ji, Yu, Kumar, Santosh, Rai, Sunil, Reynolds, Kurt, Zhou, Chengji J   +5 more
core  

Germline MUTYH (MYH) mutations in Portuguese individuals with multiple colorectal adenomas [PDF]

, 2004
Germinal mutations in the base excision repair (BER) gene MUTYH (MYH) have recently been described in association with predisposition to multiple colorectal adenomas and cancer.
Boavida, MG, Brehm, A, Brito, MJ, Castro e Sousa, F, Castro, C, Gaspar, I, Giria, J, Isidro, G, Jorge, R, Laranjeira, F, Leite, J, Marinho, C, Medeira, A, Morna, H, Pires, A, Ramos, JS, Regateiro, FJ, Soares, J, Teixeira, R   +18 more
core   +1 more source

Beyond the chaos: How architecture structures tumour biology

The FEBS Journal, Volume 293, Issue 9, Page 2519-2540, May 2026.
Tissue architecture shapes tumour initiation and progression through multiple interconnected layers continuously remodelled over time. This review outlines how physical forces, biochemical cues, cellular niches and systemic influences contribute to tumour evolution.
Lea Dörner, Catrin Lutz, Stefan Prekovic, Hendrik A. Messal   +3 more
wiley   +1 more source

m6A RNA methylation-mediated control of global APC expression is required for local translation of β-actin and axon development

Cell Reports
Summary: The spatial regulation of mRNAs in neurons, including their localization and translation, is controlled by RNA-binding proteins and is critical for neuronal development.
Loic Broix, Rohini Roy, Belal Shohayeb, Ikumi Oomoto, Hiroki Umeshima, Dan Ohtan Wang   +5 more
doaj   +1 more source

WNT signalling in prostate cancer [PDF]

, 2017
Genome sequencing and gene expression analyses of prostate tumours have highlighted the potential importance of genetic and epigenetic changes observed in WNT signalling pathway components in prostate tumours-particularly in the development of castration-
A Ghoshal, A Gurney, A Jimeno, A Klaus, A Mallinger, A Mikels, A Säfholm, A Säfholm, AB El-Khoueiry, AC Vidal, AD,MR Kohn, AH Nile, AL Giraudet, AS Khaja, AS Perry, ASS Khaja, B Bilir, B Chen, B Madan, B Madan, BJ Feldman, BT MacDonald, C Fukukawa, C Lin, C Liu, C Liu, C Logan, C Niehrs, CL Chen, CM Cruciat, CS Grasso, CY Janda, D Grandy, D Robinson, D Zheng, DS Yee, DT Miyamoto, E Lee, E Lee, E Sandsmark, EE Storm, F Janku, F Ma, FC Gonsalves, G Chen, G O'Hurley, G Schulte, G Wang, GT Lee, H Beltran, H Clevers, H Hanaki, H Kimura, H Kumon, H Kumon, H Peradziryi, H Yamamoto, H Zhu, H-X Hao, HW Park, HX Hao, I Bisson, J Chinison, J Green, J Hao, J Liu, J Veeck, J Weischenfeldt, J-H Geng, JC Brase, JC Francis, JN Anastas, JP Dijksterhuis, JR Packer, K Ahmed, K Shojima, KC Valkenburg, KD Proffitt, KE Livermore, KH Emami, L Azzolin, L Fang, L Wu, L Zheng, LE Pascal, M Bordonaro, M Cojoc, M de la Roche, M Kahn, M Mancini, M Mazon, M Volante, M Yang, MD Shultz, MT Veeman, N Borcherding, N Li, N Takebe, NK Thudi, NN Yokoyama, O Dakhova, P Bovolenta, P García-Tobilla, P Le, P Polakis, P Rajan, P Uysal-Onganer, P Uysal-Onganer, PA Watson, R Eferl, R Kolb, R Siegel, R van Amerongen, R van Amerongen, RE O'Cearbhaill, RM Kypta, Robert Kypta, S Gupta, S Josson, S Martinez, S Perner, S Piccolo, S Takahashi, S Terry, S Thiele, S Thiele, S Zhang, S-P Huang, SA Tomlins, SH Lee, SJ Cooper, SJ Hotte, SJ Jung, SP Acebron, SP Acebron, T Chandrasekar, T Haikarainen, T Karantanos, T Malinauskas, T Phesse, TD Rachner, TM Bauman, TS Gujral, V Teneggi, Virginia Murillo-Garzón, W Lu, W Lu, W Tian, W Wang, X Chen, X Jiang, X Li, X Varelas, Y Eun-Jin, Y Kawano, Y Komiya, Y Li, Y Sun, Y Sun, Y Xie, Y Yang, Y Zhou, Y Zong, Z Debebe, Z Steinhart, ZG Li, ZJ Debruine   +166 more
core   +2 more sources

The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules

Proceedings of the National Academy of Sciences, 1998
The evolutionarily conserved protein EB1 originally was identified by its physical association with the carboxyl-terminal portion of the adenomatous polyposis coli (APC) tumor suppressor protein, an APC domain commonly mutated in familial and sporadic forms of colorectal neoplasia.
L, Berrueta, S K, Kraeft, J S, Tirnauer, S C, Schuyler, L B, Chen, D E, Hill, D, Pellman, B E, Bierer   +7 more
openaire   +3 more sources

Role of the Wnt/β-catenin signaling pathway in the development of HCC

Frontiers in Immunology
Abnormalities in the Wnt/β-catenin pathway promote the development of hepatocellular carcinoma (HCC). Mutations in CTNNB1, which encodes β-catenin, are frequently found in clinical HCC samples, as are loss-of-function mutations in signaling pathway ...
Bo Lin, Mengsen Li, Mengsen Li
doaj   +1 more source

Low-level APC mutational mosaicism is the underlying cause in a substantial fraction of unexplained colorectal adenomatous polyposis cases

, 2015
BACKGROUND: In 30-50% of patients with colorectal adenomatous polyposis, no germline mutation in the known genes APC, causing familial adenomatous polyposis, MUTYH, causing MUTYH-associated polyposis, or POLE or POLD1, causing polymerase-proofreading ...
Adam, R., Aretz, S., Becker, T., Drichel, D., Hoffmann, P., Holinski-Feder, E., Holzapfel, S., Horpaopan, S., Kerick, M., Kirfel, J., Kristiansen, G., Laner, A., Lifton, R., Nöthen, M., Perner, S., Peters, S., Schweiger, M., Spier, I., Timmermann, B., Zhao, B.   +19 more
core   +1 more source

Elucidation of the WNT & AKT/Phosphoinositide-3-Kinase Pathways in Colorectal Carcinoma [PDF]

, 2004
Colorectal cancer (CRC) is the third most common cancer III Malaysia and is currently the commonest cancer in males. Genetics, experimental and epidemiological data suggest that CRC develops from complex interaction between inherited susceptibility ...
Khor, Tin Oo
core  

Membrane Localization of Adenomatous Polyposis Coli Protein at Cellular Protrusions [PDF]

Journal of Biological Chemistry, 2006
Manisha Sharma, Louie Leung, Mariana Brocardo, Jasmine Henderson, Cameron Flegg, Beric R. Henderson   +5 more
openaire   +1 more source